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Gene: EIF5A |
Gene summary for EIF5A |
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Gene information | Species | Human | Gene symbol | EIF5A | Gene ID | 1984 |
Gene name | eukaryotic translation initiation factor 5A | |
Gene Alias | EIF-5A | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P63241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1984 | EIF5A | GSM4909281 | Human | Breast | IDC | 1.01e-07 | 3.20e-01 | 0.21 |
1984 | EIF5A | GSM4909285 | Human | Breast | IDC | 1.55e-17 | -6.10e-01 | 0.21 |
1984 | EIF5A | GSM4909286 | Human | Breast | IDC | 3.17e-26 | -7.15e-01 | 0.1081 |
1984 | EIF5A | GSM4909292 | Human | Breast | IDC | 1.97e-02 | -7.04e-01 | 0.1236 |
1984 | EIF5A | GSM4909294 | Human | Breast | IDC | 6.86e-13 | -5.72e-01 | 0.2022 |
1984 | EIF5A | GSM4909296 | Human | Breast | IDC | 1.17e-19 | -5.48e-01 | 0.1524 |
1984 | EIF5A | GSM4909297 | Human | Breast | IDC | 5.65e-17 | -1.38e-02 | 0.1517 |
1984 | EIF5A | GSM4909299 | Human | Breast | IDC | 1.86e-04 | -4.87e-01 | 0.035 |
1984 | EIF5A | GSM4909300 | Human | Breast | IDC | 2.11e-03 | -4.73e-01 | 0.0334 |
1984 | EIF5A | GSM4909301 | Human | Breast | IDC | 1.46e-05 | -3.23e-01 | 0.1577 |
1984 | EIF5A | GSM4909307 | Human | Breast | IDC | 5.90e-14 | -5.86e-01 | 0.1569 |
1984 | EIF5A | GSM4909308 | Human | Breast | IDC | 5.70e-23 | -6.79e-01 | 0.158 |
1984 | EIF5A | GSM4909309 | Human | Breast | IDC | 1.46e-25 | -7.14e-01 | 0.0483 |
1984 | EIF5A | GSM4909311 | Human | Breast | IDC | 1.59e-42 | -5.18e-01 | 0.1534 |
1984 | EIF5A | GSM4909312 | Human | Breast | IDC | 3.79e-13 | -4.10e-01 | 0.1552 |
1984 | EIF5A | GSM4909319 | Human | Breast | IDC | 1.31e-52 | -6.21e-01 | 0.1563 |
1984 | EIF5A | GSM4909320 | Human | Breast | IDC | 9.66e-06 | -4.39e-01 | 0.1575 |
1984 | EIF5A | GSM4909321 | Human | Breast | IDC | 2.33e-13 | -1.15e-01 | 0.1559 |
1984 | EIF5A | brca1 | Human | Breast | Precancer | 7.60e-23 | 5.08e-01 | -0.0338 |
1984 | EIF5A | brca2 | Human | Breast | Precancer | 5.04e-11 | 3.09e-01 | -0.024 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051028 | Colorectum | AD | mRNA transport | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:0006414 | Colorectum | AD | translational elongation | 21/3918 | 55/18723 | 2.53e-03 | 1.93e-02 | 21 |
GO:0043243 | Colorectum | AD | positive regulation of protein-containing complex disassembly | 14/3918 | 35/18723 | 7.92e-03 | 4.73e-02 | 14 |
GO:20012421 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway | 59/2897 | 164/18723 | 8.42e-11 | 1.20e-08 | 59 |
GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
GO:20012331 | Colorectum | SER | regulation of apoptotic signaling pathway | 101/2897 | 356/18723 | 3.05e-10 | 4.07e-08 | 101 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:19022531 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 14/2897 | 29/18723 | 3.36e-05 | 8.85e-04 | 14 |
GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
GO:20012351 | Colorectum | SER | positive regulation of apoptotic signaling pathway | 36/2897 | 126/18723 | 1.29e-04 | 2.63e-03 | 36 |
GO:19017981 | Colorectum | SER | positive regulation of signal transduction by p53 class mediator | 12/2897 | 25/18723 | 1.32e-04 | 2.66e-03 | 12 |
GO:00723311 | Colorectum | SER | signal transduction by p53 class mediator | 43/2897 | 163/18723 | 2.22e-04 | 3.90e-03 | 43 |
GO:20012441 | Colorectum | SER | positive regulation of intrinsic apoptotic signaling pathway | 20/2897 | 58/18723 | 2.76e-04 | 4.59e-03 | 20 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00723321 | Colorectum | SER | intrinsic apoptotic signaling pathway by p53 class mediator | 24/2897 | 76/18723 | 3.29e-04 | 5.22e-03 | 24 |
GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:19017961 | Colorectum | SER | regulation of signal transduction by p53 class mediator | 27/2897 | 93/18723 | 6.48e-04 | 8.71e-03 | 27 |
GO:00512361 | Colorectum | SER | establishment of RNA localization | 42/2897 | 166/18723 | 6.70e-04 | 8.96e-03 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF5A | SNV | Missense_Mutation | rs769669056 | c.166N>T | p.Arg56Cys | p.R56C | P63241 | protein_coding | deleterious(0.05) | benign(0.221) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
EIF5A | SNV | Missense_Mutation | c.158N>T | p.Ser53Leu | p.S53L | P63241 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EIF5A | SNV | Missense_Mutation | c.392T>G | p.Leu131Arg | p.L131R | P63241 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF5A | SNV | Missense_Mutation | novel | c.98N>G | p.Asp33Gly | p.D33G | P63241 | protein_coding | deleterious(0.04) | benign(0.034) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EIF5A | SNV | Missense_Mutation | c.523N>C | p.Ala175Pro | p.A175P | P63241 | protein_coding | tolerated(0.13) | benign(0.269) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
EIF5A | SNV | Missense_Mutation | novel | c.502N>A | p.Leu168Met | p.L168M | P63241 | protein_coding | tolerated(0.38) | benign(0.369) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF5A | SNV | Missense_Mutation | c.227N>T | p.Ser76Leu | p.S76L | P63241 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF5A | SNV | Missense_Mutation | novel | c.456N>T | p.Glu152Asp | p.E152D | P63241 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
EIF5A | SNV | Missense_Mutation | c.167N>A | p.Arg56His | p.R56H | P63241 | protein_coding | deleterious(0.02) | benign(0.18) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF5A | SNV | Missense_Mutation | novel | c.325N>G | p.Met109Val | p.M109V | P63241 | protein_coding | tolerated(0.07) | benign(0.071) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1984 | EIF5A | NA | SNS01-T |
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