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Gene: DVL3 |
Gene summary for DVL3 |
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Gene information | Species | Human | Gene symbol | DVL3 | Gene ID | 1857 |
Gene name | dishevelled segment polarity protein 3 | |
Gene Alias | DRS3 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q92997 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1857 | DVL3 | LZE2T | Human | Esophagus | ESCC | 4.74e-05 | 7.95e-01 | 0.082 |
1857 | DVL3 | LZE4T | Human | Esophagus | ESCC | 2.06e-12 | 2.01e-01 | 0.0811 |
1857 | DVL3 | LZE7T | Human | Esophagus | ESCC | 5.04e-08 | 3.94e-01 | 0.0667 |
1857 | DVL3 | LZE8T | Human | Esophagus | ESCC | 2.05e-02 | 9.19e-02 | 0.067 |
1857 | DVL3 | LZE20T | Human | Esophagus | ESCC | 2.81e-03 | 1.32e-01 | 0.0662 |
1857 | DVL3 | LZE24T | Human | Esophagus | ESCC | 1.29e-09 | 3.70e-01 | 0.0596 |
1857 | DVL3 | LZE21T | Human | Esophagus | ESCC | 4.07e-06 | 4.50e-01 | 0.0655 |
1857 | DVL3 | P1T-E | Human | Esophagus | ESCC | 4.75e-11 | 7.41e-01 | 0.0875 |
1857 | DVL3 | P2T-E | Human | Esophagus | ESCC | 7.14e-36 | 6.37e-01 | 0.1177 |
1857 | DVL3 | P4T-E | Human | Esophagus | ESCC | 2.97e-20 | 5.07e-01 | 0.1323 |
1857 | DVL3 | P5T-E | Human | Esophagus | ESCC | 1.31e-17 | 1.76e-01 | 0.1327 |
1857 | DVL3 | P8T-E | Human | Esophagus | ESCC | 1.53e-21 | 4.69e-01 | 0.0889 |
1857 | DVL3 | P9T-E | Human | Esophagus | ESCC | 8.77e-16 | 4.34e-01 | 0.1131 |
1857 | DVL3 | P10T-E | Human | Esophagus | ESCC | 2.08e-22 | 4.53e-01 | 0.116 |
1857 | DVL3 | P11T-E | Human | Esophagus | ESCC | 1.53e-13 | 4.64e-01 | 0.1426 |
1857 | DVL3 | P12T-E | Human | Esophagus | ESCC | 8.11e-18 | 2.34e-01 | 0.1122 |
1857 | DVL3 | P15T-E | Human | Esophagus | ESCC | 2.64e-19 | 4.90e-01 | 0.1149 |
1857 | DVL3 | P16T-E | Human | Esophagus | ESCC | 1.45e-16 | 2.93e-01 | 0.1153 |
1857 | DVL3 | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 1.25e-01 | 0.1278 |
1857 | DVL3 | P20T-E | Human | Esophagus | ESCC | 2.35e-09 | 2.27e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586025 | Skin | cSCC | positive regulation of protein kinase activity | 123/4864 | 386/18723 | 5.23e-03 | 2.64e-02 | 123 |
GO:000173821 | Skin | cSCC | morphogenesis of a polarized epithelium | 35/4864 | 94/18723 | 1.05e-02 | 4.61e-02 | 35 |
GO:0031647113 | Thyroid | PTC | regulation of protein stability | 174/5968 | 298/18723 | 2.05e-21 | 4.05e-19 | 174 |
GO:0050821113 | Thyroid | PTC | protein stabilization | 115/5968 | 191/18723 | 5.67e-16 | 4.31e-14 | 115 |
GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
GO:0016055110 | Thyroid | PTC | Wnt signaling pathway | 217/5968 | 444/18723 | 3.71e-14 | 2.30e-12 | 217 |
GO:0198738110 | Thyroid | PTC | cell-cell signaling by wnt | 217/5968 | 446/18723 | 6.68e-14 | 3.73e-12 | 217 |
GO:0031346110 | Thyroid | PTC | positive regulation of cell projection organization | 173/5968 | 353/18723 | 1.09e-11 | 4.40e-10 | 173 |
GO:0045860111 | Thyroid | PTC | positive regulation of protein kinase activity | 176/5968 | 386/18723 | 8.89e-09 | 2.17e-07 | 176 |
GO:0071900110 | Thyroid | PTC | regulation of protein serine/threonine kinase activity | 164/5968 | 359/18723 | 2.41e-08 | 5.43e-07 | 164 |
GO:0060070110 | Thyroid | PTC | canonical Wnt signaling pathway | 141/5968 | 303/18723 | 5.71e-08 | 1.21e-06 | 141 |
GO:000184118 | Thyroid | PTC | neural tube formation | 58/5968 | 102/18723 | 1.59e-07 | 3.03e-06 | 58 |
GO:0033674111 | Thyroid | PTC | positive regulation of kinase activity | 201/5968 | 467/18723 | 1.95e-07 | 3.54e-06 | 201 |
GO:000183817 | Thyroid | PTC | embryonic epithelial tube formation | 64/5968 | 121/18723 | 1.27e-06 | 1.83e-05 | 64 |
GO:001402016 | Thyroid | PTC | primary neural tube formation | 52/5968 | 94/18723 | 2.14e-06 | 2.89e-05 | 52 |
GO:002191514 | Thyroid | PTC | neural tube development | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
GO:000184310 | Thyroid | PTC | neural tube closure | 49/5968 | 88/18723 | 3.24e-06 | 4.20e-05 | 49 |
GO:00606069 | Thyroid | PTC | tube closure | 49/5968 | 89/18723 | 4.99e-06 | 6.08e-05 | 49 |
GO:003514819 | Thyroid | PTC | tube formation | 73/5968 | 148/18723 | 7.04e-06 | 8.31e-05 | 73 |
GO:006056219 | Thyroid | PTC | epithelial tube morphogenesis | 141/5968 | 325/18723 | 7.52e-06 | 8.73e-05 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa05165 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa051651 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DVL3 | SNV | Missense_Mutation | c.722N>T | p.Ser241Phe | p.S241F | Q92997 | protein_coding | deleterious(0) | benign(0.373) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DVL3 | SNV | Missense_Mutation | novel | c.703N>A | p.Phe235Ile | p.F235I | Q92997 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-B6-A0RI-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
DVL3 | SNV | Missense_Mutation | c.570N>A | p.Phe190Leu | p.F190L | Q92997 | protein_coding | tolerated(0.76) | benign(0.038) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
DVL3 | SNV | Missense_Mutation | novel | c.172N>A | p.Glu58Lys | p.E58K | Q92997 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
DVL3 | SNV | Missense_Mutation | c.596N>A | p.Ser199Asn | p.S199N | Q92997 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DVL3 | SNV | Missense_Mutation | novel | c.1933N>T | p.Arg645Cys | p.R645C | Q92997 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DVL3 | SNV | Missense_Mutation | c.1580N>T | p.Pro527Leu | p.P527L | Q92997 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
DVL3 | SNV | Missense_Mutation | c.920N>C | p.Phe307Ser | p.F307S | Q92997 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
DVL3 | SNV | Missense_Mutation | c.1761N>T | p.Lys587Asn | p.K587N | Q92997 | protein_coding | tolerated(0.27) | benign(0.255) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DVL3 | SNV | Missense_Mutation | novel | c.703N>A | p.Phe235Ile | p.F235I | Q92997 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-AG-4008-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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