Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/DENND4C_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DENND4C_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DENND4C_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DENND4C_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DENND4C_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DENND4C_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DENND4C_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DENND4C_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DENND4C_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077820 | Skin | AK | protein localization to cell periphery | 66/1910 | 333/18723 | 9.18e-08 | 4.21e-06 | 66 |
GO:004343425 | Skin | AK | response to peptide hormone | 69/1910 | 414/18723 | 2.87e-05 | 4.98e-04 | 69 |
GO:007137517 | Skin | AK | cellular response to peptide hormone stimulus | 52/1910 | 290/18723 | 3.86e-05 | 6.35e-04 | 52 |
GO:190165320 | Skin | AK | cellular response to peptide | 61/1910 | 359/18723 | 4.60e-05 | 7.21e-04 | 61 |
GO:003286919 | Skin | AK | cellular response to insulin stimulus | 39/1910 | 203/18723 | 7.61e-05 | 1.07e-03 | 39 |
GO:005105615 | Skin | AK | regulation of small GTPase mediated signal transduction | 48/1910 | 302/18723 | 1.28e-03 | 9.69e-03 | 48 |
GO:003286819 | Skin | AK | response to insulin | 43/1910 | 264/18723 | 1.37e-03 | 1.02e-02 | 43 |
GO:004657810 | Skin | AK | regulation of Ras protein signal transduction | 33/1910 | 189/18723 | 1.49e-03 | 1.08e-02 | 33 |
GO:0072659111 | Skin | SCCIS | protein localization to plasma membrane | 32/919 | 284/18723 | 1.07e-05 | 3.77e-04 | 32 |
GO:005105616 | Skin | SCCIS | regulation of small GTPase mediated signal transduction | 33/919 | 302/18723 | 1.49e-05 | 4.86e-04 | 33 |
GO:1990778110 | Skin | SCCIS | protein localization to cell periphery | 35/919 | 333/18723 | 1.93e-05 | 5.84e-04 | 35 |
GO:000726517 | Skin | SCCIS | Ras protein signal transduction | 35/919 | 337/18723 | 2.48e-05 | 6.96e-04 | 35 |
GO:0043434112 | Skin | SCCIS | response to peptide hormone | 38/919 | 414/18723 | 1.63e-04 | 3.28e-03 | 38 |
GO:004657816 | Skin | SCCIS | regulation of Ras protein signal transduction | 21/919 | 189/18723 | 4.08e-04 | 6.62e-03 | 21 |
GO:007265926 | Skin | cSCC | protein localization to plasma membrane | 118/4864 | 284/18723 | 6.43e-09 | 2.11e-07 | 118 |
GO:199077824 | Skin | cSCC | protein localization to cell periphery | 134/4864 | 333/18723 | 7.09e-09 | 2.30e-07 | 134 |
GO:000726523 | Skin | cSCC | Ras protein signal transduction | 132/4864 | 337/18723 | 6.17e-08 | 1.57e-06 | 132 |
GO:004343426 | Skin | cSCC | response to peptide hormone | 150/4864 | 414/18723 | 2.11e-06 | 3.43e-05 | 150 |
GO:007137518 | Skin | cSCC | cellular response to peptide hormone stimulus | 104/4864 | 290/18723 | 1.15e-04 | 1.06e-03 | 104 |
GO:1901653110 | Skin | cSCC | cellular response to peptide | 124/4864 | 359/18723 | 1.75e-04 | 1.49e-03 | 124 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND4C | SNV | Missense_Mutation | | c.950N>T | p.Ser317Leu | p.S317L | | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
DENND4C | SNV | Missense_Mutation | | c.2723N>G | p.Ser908Cys | p.S908C | | protein_coding | deleterious(0.02) | possibly_damaging(0.754) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DENND4C | SNV | Missense_Mutation | | c.1828N>T | p.Arg610Cys | p.R610C | | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DENND4C | SNV | Missense_Mutation | | c.5516N>T | p.Arg1839Met | p.R1839M | | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
DENND4C | SNV | Missense_Mutation | | c.2254G>A | p.Glu752Lys | p.E752K | | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DENND4C | SNV | Missense_Mutation | | c.3698G>C | p.Ser1233Thr | p.S1233T | | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DENND4C | insertion | Frame_Shift_Ins | novel | c.3706_3707insAT | p.Gly1236AspfsTer16 | p.G1236Dfs*16 | | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
DENND4C | insertion | Nonsense_Mutation | novel | c.3707_3708insAGAATCCTAAATATGAA | p.Ile1237GlufsTer3 | p.I1237Efs*3 | | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
DENND4C | insertion | Frame_Shift_Ins | novel | c.1458_1459insTACTCTCTGAACCCTCAGCTGTACCACTGCTGTACTTA | p.Ile487TyrfsTer13 | p.I487Yfs*13 | | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
DENND4C | SNV | Missense_Mutation | rs772654971 | c.1702N>T | p.Arg568Cys | p.R568C | | protein_coding | tolerated(0.15) | probably_damaging(0.928) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |