Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DDAH1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DDAH1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DDAH1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DDAH1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DDAH1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DDAH1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007145312 | Lung | AIS | cellular response to oxygen levels | 33/1849 | 177/18723 | 2.56e-04 | 4.96e-03 | 33 |
GO:000166613 | Lung | AIS | response to hypoxia | 50/1849 | 307/18723 | 2.79e-04 | 5.26e-03 | 50 |
GO:007145612 | Lung | AIS | cellular response to hypoxia | 29/1849 | 151/18723 | 3.54e-04 | 6.32e-03 | 29 |
GO:007048213 | Lung | AIS | response to oxygen levels | 54/1849 | 347/18723 | 5.15e-04 | 8.38e-03 | 54 |
GO:0019932 | Lung | AIS | second-messenger-mediated signaling | 46/1849 | 312/18723 | 3.79e-03 | 3.52e-02 | 46 |
GO:003629421 | Lung | MIAC | cellular response to decreased oxygen levels | 19/967 | 161/18723 | 6.61e-04 | 1.58e-02 | 19 |
GO:007145621 | Lung | MIAC | cellular response to hypoxia | 18/967 | 151/18723 | 8.05e-04 | 1.79e-02 | 18 |
GO:00199321 | Lung | MIAC | second-messenger-mediated signaling | 30/967 | 312/18723 | 8.15e-04 | 1.80e-02 | 30 |
GO:000166622 | Lung | MIAC | response to hypoxia | 29/967 | 307/18723 | 1.30e-03 | 2.42e-02 | 29 |
GO:003629322 | Lung | MIAC | response to decreased oxygen levels | 30/967 | 322/18723 | 1.35e-03 | 2.48e-02 | 30 |
GO:007145321 | Lung | MIAC | cellular response to oxygen levels | 19/967 | 177/18723 | 2.05e-03 | 3.23e-02 | 19 |
GO:00030731 | Lung | MIAC | regulation of systemic arterial blood pressure | 12/967 | 96/18723 | 3.86e-03 | 4.71e-02 | 12 |
GO:007048222 | Lung | MIAC | response to oxygen levels | 30/967 | 347/18723 | 4.13e-03 | 4.93e-02 | 30 |
GO:007048217 | Prostate | BPH | response to oxygen levels | 104/3107 | 347/18723 | 3.13e-10 | 1.67e-08 | 104 |
GO:003629317 | Prostate | BPH | response to decreased oxygen levels | 96/3107 | 322/18723 | 2.03e-09 | 8.26e-08 | 96 |
GO:000166617 | Prostate | BPH | response to hypoxia | 92/3107 | 307/18723 | 3.29e-09 | 1.27e-07 | 92 |
GO:007145315 | Prostate | BPH | cellular response to oxygen levels | 56/3107 | 177/18723 | 5.50e-07 | 1.09e-05 | 56 |
GO:003629415 | Prostate | BPH | cellular response to decreased oxygen levels | 51/3107 | 161/18723 | 1.66e-06 | 2.79e-05 | 51 |
GO:00714568 | Prostate | BPH | cellular response to hypoxia | 47/3107 | 151/18723 | 7.09e-06 | 1.02e-04 | 47 |
GO:0043116 | Prostate | BPH | negative regulation of vascular permeability | 9/3107 | 18/18723 | 1.09e-03 | 6.77e-03 | 9 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDAH1 | SNV | Missense_Mutation | | c.621N>A | p.His207Gln | p.H207Q | O94760 | protein_coding | deleterious(0.03) | benign(0.033) | TCGA-E2-A1BC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
DDAH1 | SNV | Missense_Mutation | rs770957315 | c.778N>A | p.Val260Met | p.V260M | O94760 | protein_coding | deleterious(0.03) | possibly_damaging(0.774) | TCGA-D5-6532-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDAH1 | SNV | Missense_Mutation | novel | c.658G>A | p.Ala220Thr | p.A220T | O94760 | protein_coding | tolerated(0.06) | possibly_damaging(0.89) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDAH1 | SNV | Missense_Mutation | novel | c.540G>T | p.Met180Ile | p.M180I | O94760 | protein_coding | deleterious(0.04) | benign(0.255) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDAH1 | SNV | Missense_Mutation | | c.762C>A | p.Asp254Glu | p.D254E | O94760 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDAH1 | SNV | Missense_Mutation | | c.340N>T | p.Leu114Phe | p.L114F | O94760 | protein_coding | deleterious(0.03) | benign(0.415) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DDAH1 | SNV | Missense_Mutation | novel | c.404G>A | p.Gly135Asp | p.G135D | O94760 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
DDAH1 | SNV | Missense_Mutation | rs202207743 | c.628N>A | p.Asp210Asn | p.D210N | O94760 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DDAH1 | SNV | Missense_Mutation | rs377746010 | c.622C>T | p.Arg208Cys | p.R208C | O94760 | protein_coding | deleterious(0.05) | possibly_damaging(0.882) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDAH1 | SNV | Missense_Mutation | novel | c.365N>G | p.Glu122Gly | p.E122G | O94760 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |