Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: COA7

Gene summary for COA7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

COA7

Gene ID

65260

Gene namecytochrome c oxidase assembly factor 7
Gene AliasC1orf163
Cytomap1p32.3
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

Q96BR5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
65260COA7LZE4THumanEsophagusESCC1.84e-021.01e-010.0811
65260COA7LZE24THumanEsophagusESCC1.10e-091.23e-010.0596
65260COA7P2T-EHumanEsophagusESCC1.70e-163.05e-010.1177
65260COA7P4T-EHumanEsophagusESCC1.81e-082.24e-010.1323
65260COA7P5T-EHumanEsophagusESCC1.69e-132.70e-010.1327
65260COA7P8T-EHumanEsophagusESCC2.53e-063.76e-020.0889
65260COA7P9T-EHumanEsophagusESCC6.76e-071.08e-010.1131
65260COA7P10T-EHumanEsophagusESCC4.26e-162.20e-010.116
65260COA7P11T-EHumanEsophagusESCC1.93e-022.47e-010.1426
65260COA7P12T-EHumanEsophagusESCC1.80e-092.49e-010.1122
65260COA7P15T-EHumanEsophagusESCC9.25e-173.53e-010.1149
65260COA7P16T-EHumanEsophagusESCC6.83e-091.02e-010.1153
65260COA7P17T-EHumanEsophagusESCC2.14e-031.45e-010.1278
65260COA7P19T-EHumanEsophagusESCC7.15e-033.44e-010.1662
65260COA7P20T-EHumanEsophagusESCC5.19e-172.63e-010.1124
65260COA7P21T-EHumanEsophagusESCC8.24e-153.86e-010.1617
65260COA7P22T-EHumanEsophagusESCC5.77e-076.20e-020.1236
65260COA7P23T-EHumanEsophagusESCC4.41e-164.53e-010.108
65260COA7P24T-EHumanEsophagusESCC1.87e-071.96e-010.1287
65260COA7P26T-EHumanEsophagusESCC6.13e-112.03e-010.1276
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0036473110Oral cavityEOLPcell death in response to oxidative stress20/221895/187237.19e-033.49e-0220
GO:003647516Oral cavityEOLPneuron death in response to oxidative stress9/221831/187238.00e-033.78e-029
GO:190320315Oral cavityEOLPregulation of oxidative stress-induced neuron death8/221827/187231.07e-024.75e-028
GO:000697933Oral cavityNEOLPresponse to oxidative stress94/2005446/187237.53e-118.58e-0994
GO:006219733Oral cavityNEOLPcellular response to chemical stress75/2005337/187234.87e-103.97e-0875
GO:003459933Oral cavityNEOLPcellular response to oxidative stress61/2005288/187231.33e-074.67e-0661
GO:007099732Oral cavityNEOLPneuron death60/2005361/187233.70e-043.50e-0360
GO:190040719Oral cavityNEOLPregulation of cellular response to oxidative stress21/200589/187233.74e-043.53e-0321
GO:190320119Oral cavityNEOLPregulation of oxidative stress-induced cell death18/200574/187236.49e-045.47e-0318
GO:001701413Oral cavityNEOLPprotein nitrosylation7/200516/187237.62e-046.16e-037
GO:001811913Oral cavityNEOLPpeptidyl-cysteine S-nitrosylation7/200516/187237.62e-046.16e-037
GO:003647323Oral cavityNEOLPcell death in response to oxidative stress21/200595/187239.36e-047.25e-0321
GO:190121431Oral cavityNEOLPregulation of neuron death52/2005319/187231.37e-039.77e-0352
GO:190288219Oral cavityNEOLPregulation of response to oxidative stress21/200598/187231.42e-031.01e-0221
GO:190121531Oral cavityNEOLPnegative regulation of neuron death36/2005208/187232.54e-031.60e-0236
GO:190320215Oral cavityNEOLPnegative regulation of oxidative stress-induced cell death13/200553/187233.24e-031.94e-0213
GO:000697918ProstateBPHresponse to oxidative stress142/3107446/187238.11e-161.36e-13142
GO:006219718ProstateBPHcellular response to chemical stress110/3107337/187232.44e-132.40e-11110
GO:003459918ProstateBPHcellular response to oxidative stress90/3107288/187234.70e-102.43e-0890
GO:007099718ProstateBPHneuron death98/3107361/187232.35e-075.12e-0698
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04714211EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa04714310EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa0471422LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471432LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471430Oral cavityOSCCThermogenesis138/3704232/84657.67e-074.35e-062.22e-06138
hsa04714113Oral cavityOSCCThermogenesis138/3704232/84657.67e-074.35e-062.22e-06138
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
COA7SNVMissense_Mutationc.343N>Ap.Gly115Serp.G115SQ96BR5protein_codingdeleterious(0.01)possibly_damaging(0.809)TCGA-A8-A0A1-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
COA7SNVMissense_Mutationc.671N>Cp.Gly224Alap.G224AQ96BR5protein_codingtolerated(1)benign(0)TCGA-AO-A03T-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
COA7insertionNonsense_Mutationnovelc.326_327insCTTAACATTTGGGTAATGTp.Ala110LeufsTer5p.A110Lfs*5Q96BR5protein_codingTCGA-A2-A0D1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapytaxotereSD
COA7insertionFrame_Shift_Insnovelc.601_602insTCACCATCTACTGTp.Asp201ValfsTer15p.D201Vfs*15Q96BR5protein_codingTCGA-AO-A0J5-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonatezoledronicPD
COA7SNVMissense_Mutationnovelc.515G>Ap.Cys172Tyrp.C172YQ96BR5protein_codingtolerated(0.11)benign(0.003)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
COA7SNVMissense_Mutationc.601N>Cp.Asp201Hisp.D201HQ96BR5protein_codingdeleterious(0.02)benign(0.253)TCGA-VS-A94X-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
COA7SNVMissense_Mutationc.344N>Ap.Gly115Aspp.G115DQ96BR5protein_codingdeleterious(0)probably_damaging(0.925)TCGA-D5-6930-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
COA7SNVMissense_Mutationnovelc.524N>Ap.Ser175Tyrp.S175YQ96BR5protein_codingdeleterious(0)probably_damaging(0.911)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
COA7SNVMissense_Mutationrs768084335c.115N>Tp.Arg39Trpp.R39WQ96BR5protein_codingdeleterious(0.01)probably_damaging(0.981)TCGA-AX-A06F-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinSD
COA7SNVMissense_Mutationrs768757974c.296N>Tp.Ala99Valp.A99VQ96BR5protein_codingtolerated(0.08)benign(0.054)TCGA-AX-A0J1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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