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Gene: CHMP4C |
Gene summary for CHMP4C |
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Gene information | Species | Human | Gene symbol | CHMP4C | Gene ID | 92421 |
Gene name | charged multivesicular body protein 4C | |
Gene Alias | SNF7-3 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q96CF2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92421 | CHMP4C | LZE4T | Human | Esophagus | ESCC | 1.96e-10 | 3.47e-01 | 0.0811 |
92421 | CHMP4C | LZE7T | Human | Esophagus | ESCC | 4.80e-03 | 1.73e-01 | 0.0667 |
92421 | CHMP4C | LZE8T | Human | Esophagus | ESCC | 8.81e-06 | 8.46e-02 | 0.067 |
92421 | CHMP4C | LZE20T | Human | Esophagus | ESCC | 7.17e-07 | 3.97e-01 | 0.0662 |
92421 | CHMP4C | LZE24T | Human | Esophagus | ESCC | 4.73e-12 | 3.74e-01 | 0.0596 |
92421 | CHMP4C | P1T-E | Human | Esophagus | ESCC | 4.20e-02 | 3.54e-01 | 0.0875 |
92421 | CHMP4C | P2T-E | Human | Esophagus | ESCC | 4.05e-12 | 3.64e-01 | 0.1177 |
92421 | CHMP4C | P4T-E | Human | Esophagus | ESCC | 8.39e-13 | 3.87e-01 | 0.1323 |
92421 | CHMP4C | P5T-E | Human | Esophagus | ESCC | 2.58e-12 | 2.71e-01 | 0.1327 |
92421 | CHMP4C | P8T-E | Human | Esophagus | ESCC | 1.20e-25 | 5.69e-01 | 0.0889 |
92421 | CHMP4C | P9T-E | Human | Esophagus | ESCC | 4.71e-08 | 1.21e-01 | 0.1131 |
92421 | CHMP4C | P10T-E | Human | Esophagus | ESCC | 1.72e-09 | 1.05e-01 | 0.116 |
92421 | CHMP4C | P11T-E | Human | Esophagus | ESCC | 1.77e-13 | 5.03e-01 | 0.1426 |
92421 | CHMP4C | P15T-E | Human | Esophagus | ESCC | 4.53e-02 | 6.97e-02 | 0.1149 |
92421 | CHMP4C | P16T-E | Human | Esophagus | ESCC | 9.45e-29 | 6.57e-01 | 0.1153 |
92421 | CHMP4C | P17T-E | Human | Esophagus | ESCC | 6.44e-07 | 4.54e-01 | 0.1278 |
92421 | CHMP4C | P20T-E | Human | Esophagus | ESCC | 1.98e-14 | 3.64e-01 | 0.1124 |
92421 | CHMP4C | P21T-E | Human | Esophagus | ESCC | 2.17e-05 | 3.24e-02 | 0.1617 |
92421 | CHMP4C | P22T-E | Human | Esophagus | ESCC | 1.12e-11 | 2.60e-01 | 0.1236 |
92421 | CHMP4C | P23T-E | Human | Esophagus | ESCC | 3.21e-19 | 7.08e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00705072 | Liver | Cirrhotic | regulation of microtubule cytoskeleton organization | 50/4634 | 148/18723 | 8.33e-03 | 3.87e-02 | 50 |
GO:0000819 | Liver | Cirrhotic | sister chromatid segregation | 65/4634 | 202/18723 | 1.01e-02 | 4.52e-02 | 65 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:000690021 | Liver | HCC | vesicle budding from membrane | 53/7958 | 61/18723 | 7.38e-13 | 3.80e-11 | 53 |
GO:004440322 | Liver | HCC | biological process involved in symbiotic interaction | 183/7958 | 290/18723 | 9.13e-13 | 4.59e-11 | 183 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:0000070 | Liver | HCC | mitotic sister chromatid segregation | 110/7958 | 168/18723 | 1.42e-09 | 4.25e-08 | 110 |
GO:00008191 | Liver | HCC | sister chromatid segregation | 128/7958 | 202/18723 | 1.59e-09 | 4.73e-08 | 128 |
GO:00447722 | Liver | HCC | mitotic cell cycle phase transition | 240/7958 | 424/18723 | 2.47e-09 | 6.84e-08 | 240 |
GO:005170122 | Liver | HCC | biological process involved in interaction with host | 128/7958 | 203/18723 | 2.51e-09 | 6.91e-08 | 128 |
GO:000703211 | Liver | HCC | endosome organization | 61/7958 | 82/18723 | 4.36e-09 | 1.15e-07 | 61 |
GO:000734611 | Liver | HCC | regulation of mitotic cell cycle | 255/7958 | 457/18723 | 4.96e-09 | 1.30e-07 | 255 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:003250911 | Liver | HCC | endosome transport via multivesicular body sorting pathway | 28/7958 | 31/18723 | 3.56e-08 | 7.87e-07 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0421714 | Oral cavity | LP | Necroptosis | 59/2418 | 159/8465 | 1.15e-02 | 3.91e-02 | 2.52e-02 | 59 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0421715 | Oral cavity | LP | Necroptosis | 59/2418 | 159/8465 | 1.15e-02 | 3.91e-02 | 2.52e-02 | 59 |
hsa0414425 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa0421712 | Prostate | BPH | Necroptosis | 45/1718 | 159/8465 | 9.23e-03 | 2.85e-02 | 1.76e-02 | 45 |
hsa04144111 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa0421713 | Prostate | BPH | Necroptosis | 45/1718 | 159/8465 | 9.23e-03 | 2.85e-02 | 1.76e-02 | 45 |
hsa0414426 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
hsa0421721 | Prostate | Tumor | Necroptosis | 46/1791 | 159/8465 | 1.20e-02 | 3.68e-02 | 2.28e-02 | 46 |
hsa0414435 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
hsa0421731 | Prostate | Tumor | Necroptosis | 46/1791 | 159/8465 | 1.20e-02 | 3.68e-02 | 2.28e-02 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP4C | SNV | Missense_Mutation | rs757068214 | c.550N>T | p.Arg184Cys | p.R184C | Q96CF2 | protein_coding | deleterious(0.03) | possibly_damaging(0.849) | TCGA-D8-A1JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine | SD |
CHMP4C | SNV | Missense_Mutation | novel | c.439N>C | p.Glu147Gln | p.E147Q | Q96CF2 | protein_coding | deleterious(0.03) | benign(0.285) | TCGA-DG-A2KJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CHMP4C | SNV | Missense_Mutation | rs755091245 | c.21C>A | p.Phe7Leu | p.F7L | Q96CF2 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHMP4C | SNV | Missense_Mutation | novel | c.356N>C | p.Val119Ala | p.V119A | Q96CF2 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AZ-6605-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfox | SD |
CHMP4C | SNV | Missense_Mutation | c.409N>A | p.Glu137Lys | p.E137K | Q96CF2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CHMP4C | SNV | Missense_Mutation | novel | c.537N>T | p.Lys179Asn | p.K179N | Q96CF2 | protein_coding | tolerated(0.44) | benign(0.02) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHMP4C | SNV | Missense_Mutation | rs142794802 | c.551G>A | p.Arg184His | p.R184H | Q96CF2 | protein_coding | tolerated(0.13) | benign(0.067) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHMP4C | SNV | Missense_Mutation | novel | c.53N>T | p.Ala18Val | p.A18V | Q96CF2 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CHMP4C | SNV | Missense_Mutation | rs562691343 | c.632N>A | p.Arg211Gln | p.R211Q | Q96CF2 | protein_coding | tolerated(0.25) | benign(0.019) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CHMP4C | SNV | Missense_Mutation | rs562691343 | c.632G>A | p.Arg211Gln | p.R211Q | Q96CF2 | protein_coding | tolerated(0.25) | benign(0.019) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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