Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: CCL3

Gene summary for CCL3

Gene summary.

Gene information	Species	Human
	Gene symbol	CCL3
	Gene ID	6348
	Gene name	C-C motif chemokine ligand 3
	Gene Alias	G0S19-1
	Cytomap	17q12
	Gene Type	protein-coding
	GO ID	GO:0000165
	UniProtAcc	A0N0R1

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
6348	CCL3	CA_HPV_1	Human	Cervix	CC	1.68e-20	7.94e-01	0.0264
6348	CCL3	N_HPV_1	Human	Cervix	N_HPV	4.45e-02	2.97e-01	0.0079
6348	CCL3	N_HPV_2	Human	Cervix	N_HPV	2.23e-13	5.33e-01	-0.0131
6348	CCL3	S43	Human	Liver	Cirrhotic	2.76e-16	-5.56e-01	-0.0187
6348	CCL3	HCC1_Meng	Human	Liver	HCC	6.33e-35	-2.99e-01	0.0246
6348	CCL3	HCC2_Meng	Human	Liver	HCC	4.26e-11	-5.38e-01	0.0107
6348	CCL3	cirrhotic1	Human	Liver	Cirrhotic	7.39e-12	-2.01e-01	0.0202
6348	CCL3	cirrhotic2	Human	Liver	Cirrhotic	1.23e-11	-6.59e-02	0.0201
6348	CCL3	cirrhotic3	Human	Liver	Cirrhotic	2.91e-05	-3.49e-01	0.0215
6348	CCL3	Pt13.c	Human	Liver	HCC	2.33e-04	3.20e-01	0.0076
6348	CCL3	S014	Human	Liver	HCC	1.64e-02	-4.90e-01	0.2254
6348	CCL3	S015	Human	Liver	HCC	9.86e-06	-5.56e-01	0.2375
6348	CCL3	S016	Human	Liver	HCC	2.35e-11	-5.56e-01	0.2243
6348	CCL3	S027	Human	Liver	HCC	4.29e-06	-1.15e-01	0.2446
6348	CCL3	S029	Human	Liver	HCC	1.55e-02	4.05e-01	0.2581
6348	CCL3	C21	Human	Oral cavity	OSCC	7.97e-76	1.92e+00	0.2678
6348	CCL3	C30	Human	Oral cavity	OSCC	4.56e-54	1.80e+00	0.3055
6348	CCL3	C51	Human	Oral cavity	OSCC	2.31e-14	6.48e-01	0.2674
6348	CCL3	C57	Human	Oral cavity	OSCC	2.96e-02	1.30e-01	0.1679
6348	CCL3	C06	Human	Oral cavity	OSCC	2.57e-09	1.08e+00	0.2699

Page: 1 2 3

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:005072721	Cervix	N_HPV	regulation of inflammatory response	29/534	386/18723	2.27e-06	1.07e-04	29
GO:000269022	Cervix	N_HPV	positive regulation of leukocyte chemotaxis	13/534	94/18723	2.61e-06	1.17e-04	13
GO:003434112	Cervix	N_HPV	response to interferon-gamma	16/534	141/18723	2.76e-06	1.21e-04	16
GO:005072921	Cervix	N_HPV	positive regulation of inflammatory response	16/534	142/18723	3.03e-06	1.28e-04	16
GO:007167422	Cervix	N_HPV	mononuclear cell migration	19/534	196/18723	3.59e-06	1.46e-04	19
GO:200040311	Cervix	N_HPV	positive regulation of lymphocyte migration	8/534	35/18723	4.96e-06	1.87e-04	8
GO:003059322	Cervix	N_HPV	neutrophil chemotaxis	13/534	103/18723	7.33e-06	2.61e-04	13
GO:005092121	Cervix	N_HPV	positive regulation of chemotaxis	15/534	141/18723	1.24e-05	4.11e-04	15
GO:00517026	Cervix	N_HPV	biological process involved in interaction with symbiont	12/534	94/18723	1.46e-05	4.55e-04	12
GO:190121422	Cervix	N_HPV	regulation of neuron death	24/534	319/18723	1.65e-05	4.95e-04	24
GO:00509202	Cervix	N_HPV	regulation of chemotaxis	19/534	223/18723	2.29e-05	6.37e-04	19
GO:000257322	Cervix	N_HPV	myeloid leukocyte differentiation	18/534	208/18723	3.04e-05	8.02e-04	18
GO:009730515	Cervix	N_HPV	response to alcohol	20/534	253/18723	4.14e-05	9.81e-04	20
GO:00017741	Cervix	N_HPV	microglial cell activation	8/534	47/18723	4.90e-05	1.13e-03	8
GO:00430302	Cervix	N_HPV	regulation of macrophage activation	9/534	61/18723	5.41e-05	1.22e-03	9
GO:20004011	Cervix	N_HPV	regulation of lymphocyte migration	9/534	61/18723	5.41e-05	1.22e-03	9
GO:005140223	Cervix	N_HPV	neuron apoptotic process	19/534	246/18723	8.73e-05	1.84e-03	19
GO:00726781	Cervix	N_HPV	T cell migration	9/534	66/18723	1.02e-04	2.06e-03	9
GO:0072676	Cervix	N_HPV	lymphocyte migration	12/534	117/18723	1.30e-04	2.47e-03	12
GO:007134611	Cervix	N_HPV	cellular response to interferon-gamma	12/534	118/18723	1.41e-04	2.64e-03	12

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0541720	Cervix	CC	Lipid and atherosclerosis	65/1267	215/8465	6.47e-09	1.10e-07	6.52e-08	65
hsa0516318	Cervix	CC	Human cytomegalovirus infection	65/1267	225/8465	4.59e-08	6.47e-07	3.83e-07	65
hsa0532314	Cervix	CC	Rheumatoid arthritis	27/1267	93/8465	3.64e-04	1.82e-03	1.07e-03	27
hsa05417110	Cervix	CC	Lipid and atherosclerosis	65/1267	215/8465	6.47e-09	1.10e-07	6.52e-08	65
hsa0516319	Cervix	CC	Human cytomegalovirus infection	65/1267	225/8465	4.59e-08	6.47e-07	3.83e-07	65
hsa0532315	Cervix	CC	Rheumatoid arthritis	27/1267	93/8465	3.64e-04	1.82e-03	1.07e-03	27
hsa0541745	Cervix	N_HPV	Lipid and atherosclerosis	22/349	215/8465	7.28e-05	7.92e-04	6.19e-04	22
hsa0541755	Cervix	N_HPV	Lipid and atherosclerosis	22/349	215/8465	7.28e-05	7.92e-04	6.19e-04	22
hsa0516312	Liver	Cirrhotic	Human cytomegalovirus infection	87/2530	225/8465	2.67e-03	1.10e-02	6.76e-03	87
hsa0541722	Liver	Cirrhotic	Lipid and atherosclerosis	80/2530	215/8465	1.18e-02	3.81e-02	2.35e-02	80
hsa0532310	Liver	Cirrhotic	Rheumatoid arthritis	38/2530	93/8465	1.52e-02	4.57e-02	2.82e-02	38
hsa0516313	Liver	Cirrhotic	Human cytomegalovirus infection	87/2530	225/8465	2.67e-03	1.10e-02	6.76e-03	87
hsa0541732	Liver	Cirrhotic	Lipid and atherosclerosis	80/2530	215/8465	1.18e-02	3.81e-02	2.35e-02	80
hsa0532311	Liver	Cirrhotic	Rheumatoid arthritis	38/2530	93/8465	1.52e-02	4.57e-02	2.82e-02	38
hsa0516322	Liver	HCC	Human cytomegalovirus infection	131/4020	225/8465	6.86e-04	2.77e-03	1.54e-03	131
hsa05142	Liver	HCC	Chagas disease	61/4020	102/8465	8.04e-03	2.17e-02	1.21e-02	61
hsa0541742	Liver	HCC	Lipid and atherosclerosis	118/4020	215/8465	1.66e-02	3.92e-02	2.18e-02	118
hsa0516332	Liver	HCC	Human cytomegalovirus infection	131/4020	225/8465	6.86e-04	2.77e-03	1.54e-03	131
hsa051421	Liver	HCC	Chagas disease	61/4020	102/8465	8.04e-03	2.17e-02	1.21e-02	61
hsa0541752	Liver	HCC	Lipid and atherosclerosis	118/4020	215/8465	1.66e-02	3.92e-02	2.18e-02	118

Page: 1 2

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand	Receptor	LRpair	Pathway	Tissue	Disease Stage
CCL3	CCR1	CCL3_CCR1	CCL	Breast	DCIS
CCL3	CCR1	CCL3_CCR1	CCL	Breast	IDC
CCL3	CCR1	CCL3_CCR1	CCL	Cervix	ADJ
CCL3	CCR5	CCL3_CCR5	CCL	Cervix	ADJ
CCL3	CCR1	CCL3_CCR1	CCL	Cervix	CC
CCL3	CCR1	CCL3_CCR1	CCL	Cervix	Healthy
CCL3	CCR1	CCL3_CCR1	CCL	Cervix	Precancer
CCL3	CCR5	CCL3_CCR5	CCL	Endometrium	AEH
CCL3	CCR1	CCL3_CCR1	CCL	Endometrium	Healthy
CCL3	ACKR2	CCL3_ACKR2	CCL	Esophagus	ESCC
CCL3	CCR5	CCL3_CCR5	CCL	HNSCC	ADJ
CCL3	CCR1	CCL3_CCR1	CCL	HNSCC	OSCC
CCL3	ACKR2	CCL3_ACKR2	CCL	HNSCC	OSCC
CCL3	ACKR2	CCL3_ACKR2	CCL	HNSCC	Precancer
CCL3	CCR1	CCL3_CCR1	CCL	Liver	Precancer
CCL3	CCR1	CCL3_CCR1	CCL	Lung	AAH
CCL3	CCR1	CCL3_CCR1	CCL	Lung	ADJ
CCL3	CCR1	CCL3_CCR1	CCL	Lung	AIS
CCL3	CCR1	CCL3_CCR1	CCL	Lung	IAC
CCL3	CCR1	CCL3_CCR1	CCL	Lung	Precancer

Page: 1 2

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

CCL3

SNV

Missense_Mutation

novel

c.123N>T

p.Gln41His

p.Q41H

P10147

protein_coding

deleterious(0.01)

benign(0.049)

TCGA-A5-A0G2-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Unknown

CCL3

SNV

Missense_Mutation

novel

c.131N>G

p.Gln44Arg

p.Q44R

P10147

protein_coding

tolerated(1)

benign(0.001)

TCGA-AP-A1DK-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

CCL3

SNV

Missense_Mutation

novel

c.73C>T

p.Leu25Phe

p.L25F

P10147

protein_coding

tolerated(1)

benign(0.005)

TCGA-B5-A3FA-01

Endometrium

uterine corpus endometrioid carcinoma

Female

>=65

I/II

Unknown

CCL3

SNV

Missense_Mutation

novel

c.178C>T

p.Pro60Ser

p.P60S

P10147

protein_coding

deleterious(0.02)

possibly_damaging(0.764)

TCGA-EO-A3AV-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Chemotherapy

carboplatin

CCL3

SNV

Missense_Mutation

rs773703371

c.203G>A

p.Arg68Gln

p.R68Q

P10147

protein_coding

deleterious(0)

possibly_damaging(0.842)

TCGA-EO-A3AY-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

CCL3

SNV

Missense_Mutation

novel

c.232N>A

p.Glu78Lys

p.E78K

P10147

protein_coding

deleterious(0.03)

benign(0.021)

TCGA-DD-A73A-01

Liver

liver hepatocellular carcinoma

Male

>=65

I/II

Unknown

CCL3

SNV

Missense_Mutation

novel

c.273N>A

p.Ser91Arg

p.S91R

P10147

protein_coding

deleterious(0)

benign(0.104)

TCGA-18-3414-01

Lung

lung squamous cell carcinoma

Male

>=65

III/IV

Unknown

CCL3

SNV

Missense_Mutation

rs190805628

c.101G>C

p.Cys34Ser

p.C34S

P10147

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-60-2698-01

Lung

lung squamous cell carcinoma

Male

<65

I/II

Chemotherapy

mithramycin

CCL3

SNV

Missense_Mutation

novel

c.106A>T

p.Ser36Cys

p.S36C

P10147

protein_coding

deleterious(0)

probably_damaging(0.971)

TCGA-85-7843-01

Lung

lung squamous cell carcinoma

Male

<65

I/II

Unknown

CCL3

SNV

Missense_Mutation

rs368462880

c.89N>T

p.Pro30Leu

p.P30L

P10147

protein_coding

deleterious(0.02)

possibly_damaging(0.751)

TCGA-CQ-6229-01

Oral cavity

head & neck squamous cell carcinoma

Male

<65

I/II

Unknown

Page: 1 2

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID	Symbol	Category	Interaction Types	Drug Claim Name	Drug Name	PMIDs
6348	CCL3	KINASE, DRUGGABLE GENOME		INFLIXIMAB	INFLIXIMAB	16219708
6348	CCL3	KINASE, DRUGGABLE GENOME		Nagrestipen	NAGRESTIPEN
6348	CCL3	KINASE, DRUGGABLE GENOME		ADJUVANT		17116174

Page: 1