|
Gene: BTRC |
Gene summary for BTRC |
Gene summary. |
Gene information | Species | Human | Gene symbol | BTRC | Gene ID | 8945 |
Gene name | beta-transducin repeat containing E3 ubiquitin protein ligase | |
Gene Alias | BETA-TRCP | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | B2R8L3 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8945 | BTRC | CCI_1 | Human | Cervix | CC | 1.48e-04 | 6.83e-01 | 0.528 |
8945 | BTRC | CCI_2 | Human | Cervix | CC | 3.58e-09 | 8.71e-01 | 0.5249 |
8945 | BTRC | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.10e-05 | -3.95e-01 | 0.0155 |
8945 | BTRC | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-03 | -2.50e-01 | -0.1464 |
8945 | BTRC | HTA11_866_2000001011 | Human | Colorectum | AD | 1.14e-05 | -2.78e-01 | -0.1001 |
8945 | BTRC | HTA11_866_3004761011 | Human | Colorectum | AD | 2.53e-02 | -3.22e-01 | 0.096 |
8945 | BTRC | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.58e-06 | -2.78e-01 | 0.0674 |
8945 | BTRC | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.49e-03 | -3.00e-01 | 0.294 |
8945 | BTRC | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.70e-02 | -1.81e-01 | 0.3859 |
8945 | BTRC | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.33e-10 | -3.53e-01 | 0.3005 |
8945 | BTRC | A015-C-203 | Human | Colorectum | FAP | 2.07e-25 | -4.04e-01 | -0.1294 |
8945 | BTRC | A015-C-204 | Human | Colorectum | FAP | 2.09e-05 | -3.64e-01 | -0.0228 |
8945 | BTRC | A002-C-201 | Human | Colorectum | FAP | 6.99e-08 | -3.28e-01 | 0.0324 |
8945 | BTRC | A001-C-119 | Human | Colorectum | FAP | 3.97e-03 | -3.40e-01 | -0.1557 |
8945 | BTRC | A001-C-108 | Human | Colorectum | FAP | 1.03e-11 | -2.20e-01 | -0.0272 |
8945 | BTRC | A002-C-205 | Human | Colorectum | FAP | 3.45e-14 | -3.78e-01 | -0.1236 |
8945 | BTRC | A001-C-104 | Human | Colorectum | FAP | 1.37e-06 | -2.65e-01 | 0.0184 |
8945 | BTRC | A015-C-005 | Human | Colorectum | FAP | 4.33e-03 | -2.90e-01 | -0.0336 |
8945 | BTRC | A015-C-006 | Human | Colorectum | FAP | 4.33e-10 | -3.91e-01 | -0.0994 |
8945 | BTRC | A015-C-106 | Human | Colorectum | FAP | 1.38e-12 | -3.32e-01 | -0.0511 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00002093 | Colorectum | FAP | protein polyubiquitination | 59/2622 | 236/18723 | 4.53e-06 | 1.52e-04 | 59 |
GO:00608283 | Colorectum | FAP | regulation of canonical Wnt signaling pathway | 62/2622 | 253/18723 | 5.26e-06 | 1.69e-04 | 62 |
GO:00600703 | Colorectum | FAP | canonical Wnt signaling pathway | 71/2622 | 303/18723 | 6.23e-06 | 1.96e-04 | 71 |
GO:00316474 | Colorectum | FAP | regulation of protein stability | 70/2622 | 298/18723 | 6.60e-06 | 2.04e-04 | 70 |
GO:00226123 | Colorectum | FAP | gland morphogenesis | 34/2622 | 118/18723 | 2.13e-05 | 5.12e-04 | 34 |
GO:19030504 | Colorectum | FAP | regulation of proteolysis involved in cellular protein catabolic process | 54/2622 | 221/18723 | 2.26e-05 | 5.32e-04 | 54 |
GO:00458624 | Colorectum | FAP | positive regulation of proteolysis | 81/2622 | 372/18723 | 2.64e-05 | 6.08e-04 | 81 |
GO:00605622 | Colorectum | FAP | epithelial tube morphogenesis | 71/2622 | 325/18723 | 7.23e-05 | 1.33e-03 | 71 |
GO:00313964 | Colorectum | FAP | regulation of protein ubiquitination | 50/2622 | 210/18723 | 9.03e-05 | 1.59e-03 | 50 |
GO:00427523 | Colorectum | FAP | regulation of circadian rhythm | 33/2622 | 121/18723 | 9.26e-05 | 1.59e-03 | 33 |
GO:00431222 | Colorectum | FAP | regulation of I-kappaB kinase/NF-kappaB signaling | 56/2622 | 249/18723 | 1.82e-04 | 2.69e-03 | 56 |
GO:00017632 | Colorectum | FAP | morphogenesis of a branching structure | 44/2622 | 196/18723 | 8.79e-04 | 9.01e-03 | 44 |
GO:00308793 | Colorectum | FAP | mammary gland development | 33/2622 | 137/18723 | 1.07e-03 | 1.04e-02 | 33 |
GO:00072492 | Colorectum | FAP | I-kappaB kinase/NF-kappaB signaling | 58/2622 | 281/18723 | 1.37e-03 | 1.24e-02 | 58 |
GO:00506732 | Colorectum | FAP | epithelial cell proliferation | 84/2622 | 437/18723 | 1.39e-03 | 1.25e-02 | 84 |
GO:19046663 | Colorectum | FAP | regulation of ubiquitin protein ligase activity | 9/2622 | 23/18723 | 2.60e-03 | 2.03e-02 | 9 |
GO:00611364 | Colorectum | FAP | regulation of proteasomal protein catabolic process | 40/2622 | 187/18723 | 3.69e-03 | 2.62e-02 | 40 |
GO:00611381 | Colorectum | FAP | morphogenesis of a branching epithelium | 39/2622 | 182/18723 | 3.98e-03 | 2.76e-02 | 39 |
GO:00604432 | Colorectum | FAP | mammary gland morphogenesis | 13/2622 | 43/18723 | 4.69e-03 | 3.16e-02 | 13 |
GO:00510901 | Colorectum | FAP | regulation of DNA-binding transcription factor activity | 80/2622 | 440/18723 | 7.90e-03 | 4.67e-02 | 80 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0421810 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0421815 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa04218 | Colorectum | AD | Cellular senescence | 53/2092 | 156/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 53 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
Page: 1 2 3 4 5 6 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTRC | SNV | Missense_Mutation | novel | c.226N>G | p.Leu76Val | p.L76V | Q9Y297 | protein_coding | tolerated_low_confidence(0.19) | possibly_damaging(0.745) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BTRC | SNV | Missense_Mutation | novel | c.1141C>T | p.His381Tyr | p.H381Y | Q9Y297 | protein_coding | deleterious(0.05) | probably_damaging(0.998) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTRC | SNV | Missense_Mutation | c.934N>A | p.Asp312Asn | p.D312N | Q9Y297 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTRC | SNV | Missense_Mutation | c.580N>C | p.Glu194Gln | p.E194Q | Q9Y297 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BTRC | SNV | Missense_Mutation | novel | c.1379N>C | p.Arg460Thr | p.R460T | Q9Y297 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
BTRC | SNV | Missense_Mutation | c.113N>A | p.Arg38Gln | p.R38Q | Q9Y297 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-LL-A5YL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
BTRC | insertion | Frame_Shift_Ins | rs774921343 | c.1773_1774insC | p.Arg594ProfsTer27 | p.R594Pfs*27 | Q9Y297 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BTRC | deletion | Frame_Shift_Del | novel | c.1781_1790delGTTCCCCTTC | p.Arg594LeufsTer11 | p.R594Lfs*11 | Q9Y297 | protein_coding | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
BTRC | SNV | Missense_Mutation | c.83C>G | p.Ser28Cys | p.S28C | Q9Y297 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.923) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
BTRC | SNV | Missense_Mutation | novel | c.350N>T | p.Ser117Ile | p.S117I | Q9Y297 | protein_coding | tolerated_low_confidence(0.13) | benign(0.096) | TCGA-EA-A4BA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |