Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/BICD1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/BICD1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/BICD1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/BICD1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/BICD1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/BICD1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301006 | Lung | IAC | regulation of endocytosis | 38/2061 | 211/18723 | 1.54e-03 | 1.64e-02 | 38 |
GO:0099111 | Lung | IAC | microtubule-based transport | 35/2061 | 190/18723 | 1.55e-03 | 1.64e-02 | 35 |
GO:19038298 | Lung | IAC | positive regulation of cellular protein localization | 46/2061 | 276/18723 | 2.74e-03 | 2.50e-02 | 46 |
GO:00340634 | Lung | IAC | stress granule assembly | 8/2061 | 26/18723 | 5.38e-03 | 4.03e-02 | 8 |
GO:00109704 | Lung | IAC | transport along microtubule | 28/2061 | 155/18723 | 5.72e-03 | 4.18e-02 | 28 |
GO:0034453 | Lung | IAC | microtubule anchoring | 8/2061 | 27/18723 | 6.91e-03 | 4.75e-02 | 8 |
GO:001603213 | Lung | AIS | viral process | 85/1849 | 415/18723 | 4.74e-11 | 1.95e-08 | 85 |
GO:000689812 | Lung | AIS | receptor-mediated endocytosis | 50/1849 | 244/18723 | 4.47e-07 | 3.52e-05 | 50 |
GO:003010012 | Lung | AIS | regulation of endocytosis | 40/1849 | 211/18723 | 4.10e-05 | 1.23e-03 | 40 |
GO:003070512 | Lung | AIS | cytoskeleton-dependent intracellular transport | 37/1849 | 195/18723 | 7.68e-05 | 1.95e-03 | 37 |
GO:004825912 | Lung | AIS | regulation of receptor-mediated endocytosis | 24/1849 | 110/18723 | 1.54e-04 | 3.26e-03 | 24 |
GO:007050712 | Lung | AIS | regulation of microtubule cytoskeleton organization | 28/1849 | 148/18723 | 5.69e-04 | 8.89e-03 | 28 |
GO:005165612 | Lung | AIS | establishment of organelle localization | 59/1849 | 390/18723 | 6.08e-04 | 9.24e-03 | 59 |
GO:190382913 | Lung | AIS | positive regulation of cellular protein localization | 43/1849 | 276/18723 | 1.77e-03 | 2.01e-02 | 43 |
GO:003406312 | Lung | AIS | stress granule assembly | 8/1849 | 26/18723 | 2.74e-03 | 2.75e-02 | 8 |
GO:00344531 | Lung | AIS | microtubule anchoring | 8/1849 | 27/18723 | 3.56e-03 | 3.35e-02 | 8 |
GO:00715395 | Lung | AIS | protein localization to centrosome | 9/1849 | 33/18723 | 3.77e-03 | 3.51e-02 | 9 |
GO:00458075 | Lung | AIS | positive regulation of endocytosis | 19/1849 | 100/18723 | 3.90e-03 | 3.59e-02 | 19 |
GO:00482605 | Lung | AIS | positive regulation of receptor-mediated endocytosis | 12/1849 | 52/18723 | 4.05e-03 | 3.65e-02 | 12 |
GO:19055085 | Lung | AIS | protein localization to microtubule organizing center | 9/1849 | 35/18723 | 5.76e-03 | 4.81e-02 | 9 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BICD1 | SNV | Missense_Mutation | | c.316N>G | p.Leu106Val | p.L106V | Q96G01 | protein_coding | tolerated(0.38) | possibly_damaging(0.468) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
BICD1 | SNV | Missense_Mutation | | c.751N>C | p.Glu251Gln | p.E251Q | Q96G01 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BICD1 | SNV | Missense_Mutation | | c.1861G>C | p.Glu621Gln | p.E621Q | Q96G01 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
BICD1 | deletion | Frame_Shift_Del | novel | c.1190delN | p.Asp398ThrfsTer16 | p.D398Tfs*16 | Q96G01 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
BICD1 | SNV | Missense_Mutation | rs756217437 | c.490N>T | p.Arg164Trp | p.R164W | Q96G01 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BICD1 | SNV | Missense_Mutation | | c.1958N>C | p.Arg653Thr | p.R653T | Q96G01 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-EK-A2RB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | rs757213231 | c.2792N>T | p.Pro931Leu | p.P931L | Q96G01 | protein_coding | tolerated_low_confidence(0.06) | benign(0.198) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | | c.58C>A | p.Leu20Ile | p.L20I | Q96G01 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | | c.1813N>G | p.Thr605Ala | p.T605A | Q96G01 | protein_coding | tolerated(0.56) | benign(0.009) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BICD1 | SNV | Missense_Mutation | | c.2528N>C | p.Gln843Pro | p.Q843P | Q96G01 | protein_coding | tolerated_low_confidence(0.1) | benign(0.374) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |