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Gene: BAG3 |
Gene summary for BAG3 |
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Gene information | Species | Human | Gene symbol | BAG3 | Gene ID | 9531 |
Gene name | BAG cochaperone 3 | |
Gene Alias | BAG-3 | |
Cytomap | 10q26.11 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O95817 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9531 | BAG3 | CA_HPV_3 | Human | Cervix | CC | 1.63e-02 | 1.44e-01 | 0.0414 |
9531 | BAG3 | sample1 | Human | Cervix | CC | 1.89e-31 | 1.13e+00 | 0.0959 |
9531 | BAG3 | T1 | Human | Cervix | CC | 2.28e-51 | 1.13e+00 | 0.0918 |
9531 | BAG3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.45e-04 | 3.11e-01 | -0.0811 |
9531 | BAG3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.06e-05 | 3.05e-01 | -0.059 |
9531 | BAG3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.97e-23 | 6.95e-01 | 0.294 |
9531 | BAG3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.48e-07 | 4.23e-01 | 0.281 |
9531 | BAG3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.45e-15 | 5.80e-01 | 0.3859 |
9531 | BAG3 | CRC-3-11773 | Human | Colorectum | CRC | 1.66e-07 | 4.94e-01 | 0.2564 |
9531 | BAG3 | LZE2D | Human | Esophagus | HGIN | 1.73e-06 | -4.13e-01 | 0.0642 |
9531 | BAG3 | LZE4T | Human | Esophagus | ESCC | 3.59e-08 | 1.19e+00 | 0.0811 |
9531 | BAG3 | LZE7T | Human | Esophagus | ESCC | 8.88e-07 | -3.63e-01 | 0.0667 |
9531 | BAG3 | LZE8T | Human | Esophagus | ESCC | 2.03e-15 | -4.65e-01 | 0.067 |
9531 | BAG3 | LZE20T | Human | Esophagus | ESCC | 1.71e-05 | 9.95e-01 | 0.0662 |
9531 | BAG3 | LZE22D1 | Human | Esophagus | HGIN | 4.24e-08 | -6.25e-01 | 0.0595 |
9531 | BAG3 | LZE24D1 | Human | Esophagus | HGIN | 6.69e-03 | 2.39e-01 | 0.054 |
9531 | BAG3 | LZE24T | Human | Esophagus | ESCC | 1.41e-11 | 1.08e+00 | 0.0596 |
9531 | BAG3 | LZE6T | Human | Esophagus | ESCC | 1.46e-05 | -4.21e-01 | 0.0845 |
9531 | BAG3 | P2T-E | Human | Esophagus | ESCC | 1.92e-24 | 9.81e-01 | 0.1177 |
9531 | BAG3 | P4T-E | Human | Esophagus | ESCC | 2.19e-48 | 2.80e+00 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19038292 | Colorectum | MSS | positive regulation of cellular protein localization | 103/3467 | 276/18723 | 1.12e-13 | 2.67e-11 | 103 |
GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
GO:00313312 | Colorectum | MSS | positive regulation of cellular catabolic process | 140/3467 | 427/18723 | 7.02e-13 | 1.33e-10 | 140 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
GO:19049512 | Colorectum | MSS | positive regulation of establishment of protein localization | 110/3467 | 319/18723 | 6.30e-12 | 9.83e-10 | 110 |
GO:00316472 | Colorectum | MSS | regulation of protein stability | 103/3467 | 298/18723 | 2.52e-11 | 3.49e-09 | 103 |
GO:00512222 | Colorectum | MSS | positive regulation of protein transport | 104/3467 | 303/18723 | 3.23e-11 | 4.11e-09 | 104 |
GO:00069132 | Colorectum | MSS | nucleocytoplasmic transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:00511692 | Colorectum | MSS | nuclear transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:19001802 | Colorectum | MSS | regulation of protein localization to nucleus | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:00903162 | Colorectum | MSS | positive regulation of intracellular protein transport | 60/3467 | 160/18723 | 1.18e-08 | 7.08e-07 | 60 |
GO:00508212 | Colorectum | MSS | protein stabilization | 68/3467 | 191/18723 | 1.53e-08 | 8.81e-07 | 68 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00323882 | Colorectum | MSS | positive regulation of intracellular transport | 70/3467 | 202/18723 | 3.32e-08 | 1.82e-06 | 70 |
GO:00345042 | Colorectum | MSS | protein localization to nucleus | 92/3467 | 290/18723 | 3.66e-08 | 1.98e-06 | 92 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00331572 | Colorectum | MSS | regulation of intracellular protein transport | 76/3467 | 229/18723 | 7.03e-08 | 3.56e-06 | 76 |
GO:00323862 | Colorectum | MSS | regulation of intracellular transport | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:19001822 | Colorectum | MSS | positive regulation of protein localization to nucleus | 37/3467 | 87/18723 | 1.88e-07 | 8.26e-06 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAG3 | SNV | Missense_Mutation | rs747274078 | c.289N>T | p.Pro97Ser | p.P97S | O95817 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0XO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BAG3 | insertion | Frame_Shift_Ins | novel | c.1428_1429insATCCGCAAAGAGGTGGATTCTAAAC | p.Arg477IlefsTer27 | p.R477Ifs*27 | O95817 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
BAG3 | insertion | In_Frame_Ins | novel | c.456_457insGCTGGGATTACAGGCACC | p.Gly152_Gln153insAlaGlyIleThrGlyThr | p.G152_Q153insAGITGT | O95817 | protein_coding | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BAG3 | SNV | Missense_Mutation | novel | c.637G>A | p.Glu213Lys | p.E213K | O95817 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG3 | SNV | Missense_Mutation | novel | c.1091T>C | p.Val364Ala | p.V364A | O95817 | protein_coding | tolerated(0.15) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG3 | SNV | Missense_Mutation | rs876657746 | c.362N>A | p.Arg121Gln | p.R121Q | O95817 | protein_coding | deleterious(0.05) | probably_damaging(0.944) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BAG3 | SNV | Missense_Mutation | rs144585878 | c.880N>T | p.Arg294Cys | p.R294C | O95817 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BAG3 | SNV | Missense_Mutation | novel | c.1290N>T | p.Glu430Asp | p.E430D | O95817 | protein_coding | tolerated(0.06) | benign(0.114) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BAG3 | SNV | Missense_Mutation | c.7N>A | p.Ala3Thr | p.A3T | O95817 | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BAG3 | SNV | Missense_Mutation | c.11C>T | p.Ala4Val | p.A4V | O95817 | protein_coding | deleterious(0.01) | benign(0.242) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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