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Gene: ATP5F1C |
Gene summary for ATP5F1C |
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Gene information | Species | Human | Gene symbol | ATP5F1C | Gene ID | 509 |
Gene name | ATP synthase F1 subunit gamma | |
Gene Alias | ATP5C | |
Cytomap | 10p14 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P36542 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
509 | ATP5F1C | GSM4909281 | Human | Breast | IDC | 5.14e-16 | 5.46e-01 | 0.21 |
509 | ATP5F1C | GSM4909282 | Human | Breast | IDC | 2.09e-07 | 3.39e-01 | -0.0288 |
509 | ATP5F1C | GSM4909285 | Human | Breast | IDC | 1.30e-78 | 1.12e+00 | 0.21 |
509 | ATP5F1C | GSM4909286 | Human | Breast | IDC | 5.43e-17 | 4.19e-01 | 0.1081 |
509 | ATP5F1C | GSM4909287 | Human | Breast | IDC | 9.30e-05 | 3.75e-01 | 0.2057 |
509 | ATP5F1C | GSM4909290 | Human | Breast | IDC | 4.42e-02 | 2.73e-01 | 0.2096 |
509 | ATP5F1C | GSM4909293 | Human | Breast | IDC | 6.65e-06 | 1.72e-01 | 0.1581 |
509 | ATP5F1C | GSM4909296 | Human | Breast | IDC | 1.77e-02 | 1.98e-01 | 0.1524 |
509 | ATP5F1C | GSM4909297 | Human | Breast | IDC | 1.23e-02 | 7.58e-02 | 0.1517 |
509 | ATP5F1C | GSM4909298 | Human | Breast | IDC | 9.92e-03 | 8.18e-02 | 0.1551 |
509 | ATP5F1C | GSM4909305 | Human | Breast | IDC | 1.97e-07 | 3.90e-01 | 0.0436 |
509 | ATP5F1C | GSM4909306 | Human | Breast | IDC | 9.97e-07 | 3.14e-01 | 0.1564 |
509 | ATP5F1C | GSM4909307 | Human | Breast | IDC | 8.39e-03 | 3.11e-01 | 0.1569 |
509 | ATP5F1C | GSM4909308 | Human | Breast | IDC | 2.09e-21 | 5.68e-01 | 0.158 |
509 | ATP5F1C | GSM4909311 | Human | Breast | IDC | 9.56e-15 | -2.02e-02 | 0.1534 |
509 | ATP5F1C | GSM4909312 | Human | Breast | IDC | 2.15e-07 | 3.37e-01 | 0.1552 |
509 | ATP5F1C | GSM4909315 | Human | Breast | IDC | 9.83e-22 | 6.42e-01 | 0.21 |
509 | ATP5F1C | GSM4909316 | Human | Breast | IDC | 1.03e-09 | 6.18e-01 | 0.21 |
509 | ATP5F1C | GSM4909317 | Human | Breast | IDC | 1.26e-04 | 2.68e-01 | 0.1355 |
509 | ATP5F1C | GSM4909318 | Human | Breast | IDC | 1.08e-04 | 5.75e-01 | 0.2031 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00092068 | Cervix | CC | purine ribonucleoside triphosphate biosynthetic process | 23/2311 | 68/18723 | 3.47e-06 | 9.26e-05 | 23 |
GO:00092018 | Cervix | CC | ribonucleoside triphosphate biosynthetic process | 24/2311 | 74/18723 | 4.95e-06 | 1.24e-04 | 24 |
GO:00091419 | Cervix | CC | nucleoside triphosphate metabolic process | 31/2311 | 112/18723 | 9.38e-06 | 2.11e-04 | 31 |
GO:19026009 | Cervix | CC | proton transmembrane transport | 39/2311 | 157/18723 | 1.23e-05 | 2.57e-04 | 39 |
GO:00091428 | Cervix | CC | nucleoside triphosphate biosynthetic process | 25/2311 | 85/18723 | 2.17e-05 | 3.89e-04 | 25 |
GO:19905428 | Cervix | CC | mitochondrial transmembrane transport | 26/2311 | 102/18723 | 2.10e-04 | 2.39e-03 | 26 |
GO:00196939 | Cervix | CC | ribose phosphate metabolic process | 72/2311 | 396/18723 | 4.49e-04 | 4.48e-03 | 72 |
GO:00092599 | Cervix | CC | ribonucleotide metabolic process | 70/2311 | 385/18723 | 5.35e-04 | 5.18e-03 | 70 |
GO:00463908 | Cervix | CC | ribose phosphate biosynthetic process | 39/2311 | 190/18723 | 9.02e-04 | 7.77e-03 | 39 |
GO:000915010 | Cervix | CC | purine ribonucleotide metabolic process | 66/2311 | 368/18723 | 1.09e-03 | 9.07e-03 | 66 |
GO:00092608 | Cervix | CC | ribonucleotide biosynthetic process | 37/2311 | 182/18723 | 1.44e-03 | 1.13e-02 | 37 |
GO:00091529 | Cervix | CC | purine ribonucleotide biosynthetic process | 34/2311 | 169/18723 | 2.62e-03 | 1.81e-02 | 34 |
GO:000616310 | Cervix | CC | purine nucleotide metabolic process | 67/2311 | 396/18723 | 4.41e-03 | 2.69e-02 | 67 |
GO:007252110 | Cervix | CC | purine-containing compound metabolic process | 69/2311 | 416/18723 | 6.27e-03 | 3.54e-02 | 69 |
GO:000911710 | Cervix | CC | nucleotide metabolic process | 79/2311 | 489/18723 | 7.16e-03 | 3.85e-02 | 79 |
GO:004603415 | Cervix | HSIL_HPV | ATP metabolic process | 36/737 | 277/18723 | 3.06e-10 | 7.02e-08 | 36 |
GO:000611914 | Cervix | HSIL_HPV | oxidative phosphorylation | 23/737 | 141/18723 | 6.76e-09 | 8.80e-07 | 23 |
GO:001598514 | Cervix | HSIL_HPV | energy coupled proton transport, down electrochemical gradient | 10/737 | 26/18723 | 2.52e-08 | 2.18e-06 | 10 |
GO:001598614 | Cervix | HSIL_HPV | ATP synthesis coupled proton transport | 10/737 | 26/18723 | 2.52e-08 | 2.18e-06 | 10 |
GO:000906014 | Cervix | HSIL_HPV | aerobic respiration | 23/737 | 189/18723 | 1.59e-06 | 6.90e-05 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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