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Gene: ATP5F1A |
Gene summary for ATP5F1A |
Gene summary. |
Gene information | Species | Human | Gene symbol | ATP5F1A | Gene ID | 498 |
Gene name | ATP synthase F1 subunit alpha | |
Gene Alias | ATP5A | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | P25705 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
498 | ATP5F1A | GSM4909281 | Human | Breast | IDC | 4.78e-03 | 2.77e-01 | 0.21 |
498 | ATP5F1A | GSM4909282 | Human | Breast | IDC | 3.21e-09 | 5.11e-01 | -0.0288 |
498 | ATP5F1A | GSM4909285 | Human | Breast | IDC | 2.51e-20 | 5.76e-01 | 0.21 |
498 | ATP5F1A | GSM4909286 | Human | Breast | IDC | 6.91e-17 | 2.26e-01 | 0.1081 |
498 | ATP5F1A | GSM4909287 | Human | Breast | IDC | 2.74e-04 | 3.23e-01 | 0.2057 |
498 | ATP5F1A | GSM4909290 | Human | Breast | IDC | 5.19e-04 | 2.39e-01 | 0.2096 |
498 | ATP5F1A | GSM4909293 | Human | Breast | IDC | 4.07e-08 | 3.04e-01 | 0.1581 |
498 | ATP5F1A | GSM4909295 | Human | Breast | IDC | 3.01e-02 | 3.08e-01 | 0.0898 |
498 | ATP5F1A | GSM4909297 | Human | Breast | IDC | 5.56e-04 | 1.72e-01 | 0.1517 |
498 | ATP5F1A | GSM4909298 | Human | Breast | IDC | 1.64e-04 | 1.13e-01 | 0.1551 |
498 | ATP5F1A | GSM4909299 | Human | Breast | IDC | 7.85e-03 | 2.62e-01 | 0.035 |
498 | ATP5F1A | GSM4909300 | Human | Breast | IDC | 2.01e-04 | 3.56e-01 | 0.0334 |
498 | ATP5F1A | GSM4909304 | Human | Breast | IDC | 2.40e-02 | 2.37e-01 | 0.1636 |
498 | ATP5F1A | GSM4909305 | Human | Breast | IDC | 8.54e-14 | 4.86e-01 | 0.0436 |
498 | ATP5F1A | GSM4909306 | Human | Breast | IDC | 3.58e-02 | 2.76e-01 | 0.1564 |
498 | ATP5F1A | GSM4909308 | Human | Breast | IDC | 5.08e-05 | 1.42e-01 | 0.158 |
498 | ATP5F1A | GSM4909311 | Human | Breast | IDC | 2.35e-15 | -2.79e-01 | 0.1534 |
498 | ATP5F1A | GSM4909317 | Human | Breast | IDC | 2.11e-11 | 3.38e-01 | 0.1355 |
498 | ATP5F1A | GSM4909319 | Human | Breast | IDC | 1.51e-25 | -1.37e-01 | 0.1563 |
498 | ATP5F1A | GSM4909320 | Human | Breast | IDC | 2.14e-02 | -3.66e-01 | 0.1575 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000616324 | Breast | DCIS | purine nucleotide metabolic process | 56/1390 | 396/18723 | 2.31e-06 | 8.29e-05 | 56 |
GO:000911723 | Breast | DCIS | nucleotide metabolic process | 65/1390 | 489/18723 | 3.19e-06 | 1.03e-04 | 65 |
GO:007252222 | Breast | DCIS | purine-containing compound biosynthetic process | 34/1390 | 200/18723 | 4.51e-06 | 1.34e-04 | 34 |
GO:001063121 | Breast | DCIS | epithelial cell migration | 51/1390 | 357/18723 | 4.83e-06 | 1.43e-04 | 51 |
GO:007252124 | Breast | DCIS | purine-containing compound metabolic process | 57/1390 | 416/18723 | 5.07e-06 | 1.48e-04 | 57 |
GO:000675323 | Breast | DCIS | nucleoside phosphate metabolic process | 65/1390 | 497/18723 | 5.51e-06 | 1.59e-04 | 65 |
GO:009013221 | Breast | DCIS | epithelium migration | 51/1390 | 360/18723 | 6.14e-06 | 1.75e-04 | 51 |
GO:009013021 | Breast | DCIS | tissue migration | 51/1390 | 365/18723 | 9.09e-06 | 2.45e-04 | 51 |
GO:000166723 | Breast | DCIS | ameboidal-type cell migration | 62/1390 | 475/18723 | 9.60e-06 | 2.56e-04 | 62 |
GO:001063221 | Breast | DCIS | regulation of epithelial cell migration | 43/1390 | 292/18723 | 1.23e-05 | 3.13e-04 | 43 |
GO:001063422 | Breast | DCIS | positive regulation of epithelial cell migration | 30/1390 | 176/18723 | 1.53e-05 | 3.75e-04 | 30 |
GO:005067322 | Breast | DCIS | epithelial cell proliferation | 57/1390 | 437/18723 | 2.22e-05 | 5.23e-04 | 57 |
GO:000916522 | Breast | DCIS | nucleotide biosynthetic process | 38/1390 | 254/18723 | 2.71e-05 | 6.11e-04 | 38 |
GO:005067821 | Breast | DCIS | regulation of epithelial cell proliferation | 51/1390 | 381/18723 | 2.96e-05 | 6.55e-04 | 51 |
GO:190129322 | Breast | DCIS | nucleoside phosphate biosynthetic process | 38/1390 | 256/18723 | 3.23e-05 | 7.09e-04 | 38 |
GO:004354221 | Breast | DCIS | endothelial cell migration | 40/1390 | 279/18723 | 4.54e-05 | 9.49e-04 | 40 |
GO:00105952 | Breast | DCIS | positive regulation of endothelial cell migration | 23/1390 | 133/18723 | 1.16e-04 | 2.03e-03 | 23 |
GO:00105942 | Breast | DCIS | regulation of endothelial cell migration | 33/1390 | 232/18723 | 2.35e-04 | 3.70e-03 | 33 |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:000611910 | Cervix | CC | oxidative phosphorylation | 55/2311 | 141/18723 | 7.12e-16 | 1.42e-12 | 55 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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