Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ATP2C1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ATP2C1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ATP2C1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ATP2C1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ATP2C1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ATP2C1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ATP2C1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ATP2C1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ATP2C1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ATP2C1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190495112 | Liver | Cirrhotic | positive regulation of establishment of protein localization | 135/4634 | 319/18723 | 3.20e-12 | 2.28e-10 | 135 |
GO:005122212 | Liver | Cirrhotic | positive regulation of protein transport | 126/4634 | 303/18723 | 6.85e-11 | 3.77e-09 | 126 |
GO:199077811 | Liver | Cirrhotic | protein localization to cell periphery | 135/4634 | 333/18723 | 1.18e-10 | 6.21e-09 | 135 |
GO:007265911 | Liver | Cirrhotic | protein localization to plasma membrane | 119/4634 | 284/18723 | 1.30e-10 | 6.80e-09 | 119 |
GO:004300111 | Liver | Cirrhotic | Golgi to plasma membrane protein transport | 27/4634 | 40/18723 | 1.43e-08 | 5.36e-07 | 27 |
GO:19054755 | Liver | Cirrhotic | regulation of protein localization to membrane | 76/4634 | 175/18723 | 4.55e-08 | 1.45e-06 | 76 |
GO:000689211 | Liver | Cirrhotic | post-Golgi vesicle-mediated transport | 51/4634 | 104/18723 | 7.12e-08 | 2.15e-06 | 51 |
GO:00072494 | Liver | Cirrhotic | I-kappaB kinase/NF-kappaB signaling | 108/4634 | 281/18723 | 2.21e-07 | 5.64e-06 | 108 |
GO:190437511 | Liver | Cirrhotic | regulation of protein localization to cell periphery | 57/4634 | 125/18723 | 2.97e-07 | 7.18e-06 | 57 |
GO:00619515 | Liver | Cirrhotic | establishment of protein localization to plasma membrane | 33/4634 | 60/18723 | 5.09e-07 | 1.14e-05 | 33 |
GO:009887611 | Liver | Cirrhotic | vesicle-mediated transport to the plasma membrane | 59/4634 | 136/18723 | 1.46e-06 | 2.88e-05 | 59 |
GO:00431225 | Liver | Cirrhotic | regulation of I-kappaB kinase/NF-kappaB signaling | 95/4634 | 249/18723 | 1.68e-06 | 3.22e-05 | 95 |
GO:000689311 | Liver | Cirrhotic | Golgi to plasma membrane transport | 32/4634 | 60/18723 | 1.87e-06 | 3.53e-05 | 32 |
GO:190307611 | Liver | Cirrhotic | regulation of protein localization to plasma membrane | 47/4634 | 104/18723 | 4.29e-06 | 7.15e-05 | 47 |
GO:00431234 | Liver | Cirrhotic | positive regulation of I-kappaB kinase/NF-kappaB signaling | 71/4634 | 186/18723 | 3.20e-05 | 3.97e-04 | 71 |
GO:19054775 | Liver | Cirrhotic | positive regulation of protein localization to membrane | 44/4634 | 106/18723 | 1.07e-04 | 1.10e-03 | 44 |
GO:00429962 | Liver | Cirrhotic | regulation of Golgi to plasma membrane protein transport | 8/4634 | 10/18723 | 3.84e-04 | 3.19e-03 | 8 |
GO:19043776 | Liver | Cirrhotic | positive regulation of protein localization to cell periphery | 30/4634 | 69/18723 | 5.04e-04 | 4.01e-03 | 30 |
GO:00315326 | Liver | Cirrhotic | actin cytoskeleton reorganization | 42/4634 | 107/18723 | 6.28e-04 | 4.81e-03 | 42 |
GO:19030786 | Liver | Cirrhotic | positive regulation of protein localization to plasma membrane | 26/4634 | 62/18723 | 2.18e-03 | 1.34e-02 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2C1 | SNV | Missense_Mutation | | c.514N>C | p.Glu172Gln | p.E172Q | P98194 | protein_coding | tolerated(0.17) | benign(0.037) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2C1 | SNV | Missense_Mutation | | c.2170N>A | p.Glu724Lys | p.E724K | P98194 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP2C1 | SNV | Missense_Mutation | | c.359N>C | p.Leu120Pro | p.L120P | P98194 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ATP2C1 | SNV | Missense_Mutation | | c.1271G>C | p.Gly424Ala | p.G424A | P98194 | protein_coding | tolerated(0.3) | benign(0.406) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ATP2C1 | SNV | Missense_Mutation | | c.1339N>C | p.Asp447His | p.D447H | P98194 | protein_coding | deleterious(0.01) | possibly_damaging(0.81) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ATP2C1 | SNV | Missense_Mutation | rs145949576 | c.1994C>T | p.Ser665Leu | p.S665L | P98194 | protein_coding | deleterious(0) | possibly_damaging(0.611) | TCGA-EW-A6SA-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP2C1 | insertion | Nonsense_Mutation | novel | c.195_196insTAGAATAAT | p.Val65_Ser66insTer | p.V65_S66ins* | P98194 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
ATP2C1 | deletion | Frame_Shift_Del | | c.685delT | p.Cys229ValfsTer4 | p.C229Vfs*4 | P98194 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP2C1 | deletion | Frame_Shift_Del | | c.340delN | p.Asn115IlefsTer16 | p.N115Ifs*16 | P98194 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ATP2C1 | SNV | Missense_Mutation | novel | c.2336C>T | p.Pro779Leu | p.P779L | P98194 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | ENFLURANE | ENFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | ISOFLURANE | ISOFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | SEVOFLURANE | SEVOFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | ISOFLURANE | ISOFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | ENFLURANE | ENFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | SEVOFLURANE | SEVOFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | DESFLURANE | DESFLURANE | |
27032 | ATP2C1 | ENZYME, TRANSPORTER, DRUGGABLE GENOME | | DESFLURANE | DESFLURANE | |