![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ASCL2 |
Gene summary for ASCL2 |
![]() |
Gene information | Species | Human | Gene symbol | ASCL2 | Gene ID | 430 |
Gene name | achaete-scute family bHLH transcription factor 2 | |
Gene Alias | ASH2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99929 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
430 | ASCL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.61e-11 | 3.47e-01 | 0.0155 |
430 | ASCL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.24e-12 | 9.82e-01 | 0.0216 |
430 | ASCL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.00e-04 | 4.40e-01 | -0.0811 |
430 | ASCL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.88e-02 | 3.69e-01 | -0.1207 |
430 | ASCL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.29e-13 | 5.95e-01 | -0.1464 |
430 | ASCL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.98e-02 | 2.02e-01 | -0.1001 |
430 | ASCL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.85e-19 | 9.21e-01 | -0.059 |
430 | ASCL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.29e-62 | 1.56e+00 | 0.096 |
430 | ASCL2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.79e-19 | 1.35e+00 | 0.0451 |
430 | ASCL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.44e-10 | 7.35e-01 | 0.0528 |
430 | ASCL2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.65e-05 | 8.67e-01 | 0.0131 |
430 | ASCL2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.97e-31 | 1.17e+00 | 0.0338 |
430 | ASCL2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.60e-63 | 1.50e+00 | 0.0674 |
430 | ASCL2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.92e-15 | 1.20e+00 | 0.0112 |
430 | ASCL2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.45e-12 | 1.26e+00 | 0.0397 |
430 | ASCL2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.50e-40 | 1.39e+00 | 0.0588 |
430 | ASCL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.80e-27 | 7.49e-01 | 0.294 |
430 | ASCL2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.05e-05 | 9.32e-01 | 0.3487 |
430 | ASCL2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.20e-39 | 1.35e+00 | 0.281 |
430 | ASCL2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.40e-49 | 1.10e+00 | 0.3859 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003629326 | Skin | cSCC | response to decreased oxygen levels | 119/4864 | 322/18723 | 7.98e-06 | 1.09e-04 | 119 |
GO:009872715 | Skin | cSCC | maintenance of cell number | 58/4864 | 134/18723 | 9.83e-06 | 1.29e-04 | 58 |
GO:000189223 | Skin | cSCC | embryonic placenta development | 39/4864 | 82/18723 | 2.08e-05 | 2.43e-04 | 39 |
GO:006145825 | Skin | cSCC | reproductive system development | 149/4864 | 427/18723 | 2.30e-05 | 2.65e-04 | 149 |
GO:004860824 | Skin | cSCC | reproductive structure development | 148/4864 | 424/18723 | 2.40e-05 | 2.74e-04 | 148 |
GO:000189024 | Skin | cSCC | placenta development | 60/4864 | 144/18723 | 2.84e-05 | 3.17e-04 | 60 |
GO:004206322 | Skin | cSCC | gliogenesis | 103/4864 | 301/18723 | 8.48e-04 | 5.85e-03 | 103 |
GO:005076722 | Skin | cSCC | regulation of neurogenesis | 118/4864 | 364/18723 | 3.32e-03 | 1.81e-02 | 118 |
Page: 1 2 3 4 5 6 7 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 5 6 7 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCL2 | SNV | Missense_Mutation | novel | c.127N>T | p.Ala43Ser | p.A43S | Q99929 | protein_coding | tolerated(0.97) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASCL2 | SNV | Missense_Mutation | novel | c.298N>G | p.Arg100Gly | p.R100G | Q99929 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-2Y-A9GW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |