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Gene: ANTXR1 |
Gene summary for ANTXR1 |
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Gene information | Species | Human | Gene symbol | ANTXR1 | Gene ID | 84168 |
Gene name | ANTXR cell adhesion molecule 1 | |
Gene Alias | ATR | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96EC6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84168 | ANTXR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.25e-02 | 1.40e-01 | 0.0155 |
84168 | ANTXR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.57e-05 | 2.18e-01 | -0.1808 |
84168 | ANTXR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.43e-12 | 6.44e-01 | -0.0811 |
84168 | ANTXR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.00e-03 | 2.56e-01 | -0.1088 |
84168 | ANTXR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.61e-07 | 2.04e-01 | -0.1954 |
84168 | ANTXR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.08e-11 | 2.77e-01 | -0.1464 |
84168 | ANTXR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.36e-04 | 7.04e-02 | -0.1001 |
84168 | ANTXR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.12e-07 | 2.36e-01 | -0.059 |
84168 | ANTXR1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.25e-05 | 5.13e-01 | 0.0451 |
84168 | ANTXR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.06e-06 | 1.63e-01 | 0.0674 |
84168 | ANTXR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.87e-46 | 7.80e-01 | 0.294 |
84168 | ANTXR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.73e-03 | 1.88e-01 | 0.281 |
84168 | ANTXR1 | LZE8T | Human | Esophagus | ESCC | 1.05e-03 | -3.58e-02 | 0.067 |
84168 | ANTXR1 | LZE24T | Human | Esophagus | ESCC | 4.33e-07 | 1.22e-01 | 0.0596 |
84168 | ANTXR1 | LZE21T | Human | Esophagus | ESCC | 1.15e-02 | 2.51e-02 | 0.0655 |
84168 | ANTXR1 | P1T-E | Human | Esophagus | ESCC | 8.34e-03 | 4.64e-02 | 0.0875 |
84168 | ANTXR1 | P2T-E | Human | Esophagus | ESCC | 2.73e-19 | 4.04e-01 | 0.1177 |
84168 | ANTXR1 | P4T-E | Human | Esophagus | ESCC | 3.05e-15 | 7.13e-01 | 0.1323 |
84168 | ANTXR1 | P8T-E | Human | Esophagus | ESCC | 4.64e-10 | 3.32e-01 | 0.0889 |
84168 | ANTXR1 | P9T-E | Human | Esophagus | ESCC | 6.74e-06 | 5.31e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001095233 | Thyroid | ATC | positive regulation of peptidase activity | 94/6293 | 197/18723 | 2.67e-05 | 2.28e-04 | 94 |
GO:008502911 | Thyroid | ATC | extracellular matrix assembly | 28/6293 | 45/18723 | 7.91e-05 | 5.95e-04 | 28 |
GO:190199813 | Thyroid | ATC | toxin transport | 25/6293 | 40/18723 | 1.72e-04 | 1.17e-03 | 25 |
GO:190120111 | Thyroid | ATC | regulation of extracellular matrix assembly | 12/6293 | 16/18723 | 8.59e-04 | 4.68e-03 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANTXR1 | SNV | Missense_Mutation | rs201850545 | c.1130C>T | p.Thr377Met | p.T377M | Q9H6X2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-B6-A0I9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ANTXR1 | insertion | In_Frame_Ins | novel | c.490_491insGAAGATATAATGGGGACCAAAACAGCCATGGCCCAGTCCTCA | p.Glu164delinsGlyArgTyrAsnGlyAspGlnAsnSerHisGlyProValLeuLys | p.E164delinsGRYNGDQNSHGPVLK | Q9H6X2 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ANTXR1 | deletion | Frame_Shift_Del | novel | c.629delG | p.Gly210AlafsTer7 | p.G210Afs*7 | Q9H6X2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ANTXR1 | SNV | Missense_Mutation | novel | c.1652N>T | p.Arg551Met | p.R551M | Q9H6X2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.041) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
ANTXR1 | SNV | Missense_Mutation | c.588N>A | p.Asp196Glu | p.D196E | Q9H6X2 | protein_coding | tolerated(0.75) | benign(0.036) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANTXR1 | SNV | Missense_Mutation | c.589N>T | p.His197Tyr | p.H197Y | Q9H6X2 | protein_coding | tolerated(0.06) | benign(0.299) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANTXR1 | SNV | Missense_Mutation | novel | c.1111N>T | p.Pro371Ser | p.P371S | Q9H6X2 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANTXR1 | SNV | Missense_Mutation | c.308G>A | p.Arg103His | p.R103H | Q9H6X2 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ANTXR1 | SNV | Missense_Mutation | rs370351341 | c.1438C>T | p.Arg480Cys | p.R480C | Q9H6X2 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANTXR1 | SNV | Missense_Mutation | rs149800589 | c.1316G>A | p.Arg439Gln | p.R439Q | Q9H6X2 | protein_coding | tolerated(0.27) | benign(0.354) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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