Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/FN1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/FN1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/FN1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/FN1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/FN1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/FN1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/FN1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/FN1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000155812 | Lung | AIS | regulation of cell growth | 62/1849 | 414/18723 | 5.85e-04 | 9.03e-03 | 62 |
GO:001063111 | Lung | AIS | epithelial cell migration | 55/1849 | 357/18723 | 5.89e-04 | 9.03e-03 | 55 |
GO:00481451 | Lung | AIS | regulation of fibroblast proliferation | 18/1849 | 80/18723 | 6.68e-04 | 1.00e-02 | 18 |
GO:000183811 | Lung | AIS | embryonic epithelial tube formation | 24/1849 | 121/18723 | 6.82e-04 | 1.02e-02 | 24 |
GO:005080811 | Lung | AIS | synapse organization | 63/1849 | 426/18723 | 7.39e-04 | 1.07e-02 | 63 |
GO:00481441 | Lung | AIS | fibroblast proliferation | 18/1849 | 81/18723 | 7.81e-04 | 1.11e-02 | 18 |
GO:00508788 | Lung | AIS | regulation of body fluid levels | 57/1849 | 379/18723 | 8.60e-04 | 1.17e-02 | 57 |
GO:003152912 | Lung | AIS | ruffle organization | 14/1849 | 56/18723 | 8.61e-04 | 1.17e-02 | 14 |
GO:002191511 | Lung | AIS | neural tube development | 28/1849 | 152/18723 | 8.81e-04 | 1.19e-02 | 28 |
GO:001095213 | Lung | AIS | positive regulation of peptidase activity | 34/1849 | 197/18723 | 8.94e-04 | 1.20e-02 | 34 |
GO:003227313 | Lung | AIS | positive regulation of protein polymerization | 26/1849 | 138/18723 | 9.38e-04 | 1.24e-02 | 26 |
GO:0070372 | Lung | AIS | regulation of ERK1 and ERK2 cascade | 48/1849 | 309/18723 | 1.06e-03 | 1.38e-02 | 48 |
GO:00163311 | Lung | AIS | morphogenesis of embryonic epithelium | 27/1849 | 147/18723 | 1.13e-03 | 1.45e-02 | 27 |
GO:003514811 | Lung | AIS | tube formation | 27/1849 | 148/18723 | 1.25e-03 | 1.58e-02 | 27 |
GO:003030712 | Lung | AIS | positive regulation of cell growth | 29/1849 | 166/18723 | 1.70e-03 | 1.93e-02 | 29 |
GO:003253513 | Lung | AIS | regulation of cellular component size | 56/1849 | 383/18723 | 1.83e-03 | 2.05e-02 | 56 |
GO:003444613 | Lung | AIS | substrate adhesion-dependent cell spreading | 21/1849 | 108/18723 | 1.86e-03 | 2.07e-02 | 21 |
GO:190002711 | Lung | AIS | regulation of ruffle assembly | 9/1849 | 31/18723 | 2.36e-03 | 2.48e-02 | 9 |
GO:00073694 | Lung | AIS | gastrulation | 31/1849 | 185/18723 | 2.37e-03 | 2.48e-02 | 31 |
GO:007217511 | Lung | AIS | epithelial tube formation | 24/1849 | 132/18723 | 2.37e-03 | 2.48e-02 | 24 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa045109 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0510034 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481015 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0451013 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa051004 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
hsa051354 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa052054 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
hsa048104 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa05222 | Colorectum | MSS | Small cell lung cancer | 30/1875 | 92/8465 | 1.31e-02 | 4.30e-02 | 2.64e-02 | 30 |
hsa051005 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FN1 | SNV | Missense_Mutation | | c.7241N>A | p.Gly2414Glu | p.G2414E | P02751 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD |
FN1 | SNV | Missense_Mutation | | c.3291G>C | p.Glu1097Asp | p.E1097D | P02751 | protein_coding | tolerated(0.31) | probably_damaging(0.992) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FN1 | SNV | Missense_Mutation | | c.1094C>G | p.Thr365Ser | p.T365S | P02751 | protein_coding | deleterious(0.02) | benign(0.066) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | | c.968N>C | p.Leu323Pro | p.L323P | P02751 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | rs750176227 | c.274N>A | p.Glu92Lys | p.E92K | P02751 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
FN1 | SNV | Missense_Mutation | | c.2488N>T | p.Arg830Cys | p.R830C | P02751 | protein_coding | deleterious(0.01) | possibly_damaging(0.683) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | | c.331A>G | p.Thr111Ala | p.T111A | P02751 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | | c.4034N>A | p.Gly1345Asp | p.G1345D | P02751 | protein_coding | tolerated(0.11) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
FN1 | SNV | Missense_Mutation | rs149294265 | c.7402N>A | p.Val2468Ile | p.V2468I | P02751 | protein_coding | tolerated(0.1) | benign(0.023) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
FN1 | SNV | Missense_Mutation | | c.1717N>A | p.Gly573Arg | p.G573R | P02751 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |