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Gene: TAT |
Gene summary for TAT |
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Gene information | Species | Human | Gene symbol | TAT | Gene ID | 6898 |
Gene name | tyrosine aminotransferase | |
Gene Alias | TAT | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A140VKB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6898 | TAT | NAFLD1 | Human | Liver | NAFLD | 4.94e-17 | 1.55e+00 | -0.04 |
6898 | TAT | S41 | Human | Liver | Cirrhotic | 4.91e-08 | 9.39e-01 | -0.0343 |
6898 | TAT | S43 | Human | Liver | Cirrhotic | 9.02e-05 | 2.24e-01 | -0.0187 |
6898 | TAT | S44 | Human | Liver | HCC | 1.65e-15 | 1.47e+00 | -0.0083 |
6898 | TAT | HCC1_Meng | Human | Liver | HCC | 3.18e-12 | -2.89e-01 | 0.0246 |
6898 | TAT | HCC2_Meng | Human | Liver | HCC | 5.02e-08 | -3.06e-01 | 0.0107 |
6898 | TAT | cirrhotic1 | Human | Liver | Cirrhotic | 2.73e-06 | -2.90e-01 | 0.0202 |
6898 | TAT | cirrhotic2 | Human | Liver | Cirrhotic | 1.92e-03 | -2.62e-01 | 0.0201 |
6898 | TAT | HCC2 | Human | Liver | HCC | 3.75e-04 | 2.29e+00 | 0.5341 |
6898 | TAT | Pt13.b | Human | Liver | HCC | 2.29e-06 | -1.10e-01 | 0.0251 |
6898 | TAT | Pt14.b | Human | Liver | HCC | 1.34e-04 | 6.11e-02 | 0.018 |
6898 | TAT | Pt14.d | Human | Liver | HCC | 2.29e-05 | -2.81e-01 | 0.0143 |
6898 | TAT | S016 | Human | Liver | HCC | 5.80e-04 | -3.06e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0009895111 | Esophagus | ESCC | negative regulation of catabolic process | 201/8552 | 320/18723 | 3.88e-10 | 1.05e-08 | 201 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:0010952111 | Esophagus | ESCC | positive regulation of peptidase activity | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAT | SNV | Missense_Mutation | novel | c.533N>G | p.Ser178Cys | p.S178C | P17735 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TAT | SNV | Missense_Mutation | c.1137G>T | p.Glu379Asp | p.E379D | P17735 | protein_coding | tolerated(1) | benign(0.005) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TAT | SNV | Missense_Mutation | c.169N>G | p.Arg57Gly | p.R57G | P17735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
TAT | SNV | Missense_Mutation | c.58N>A | p.Val20Met | p.V20M | P17735 | protein_coding | deleterious_low_confidence(0.01) | benign(0.022) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
TAT | SNV | Missense_Mutation | c.868G>C | p.Gly290Arg | p.G290R | P17735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
TAT | insertion | Frame_Shift_Ins | novel | c.35_36insTGAAACCAAATCCAAACAAAAC | p.Asn13GlufsTer87 | p.N13Efs*87 | P17735 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TAT | insertion | Frame_Shift_Ins | novel | c.1118_1121dupACCT | p.Met375ProfsTer6 | p.M375Pfs*6 | P17735 | protein_coding | TCGA-E9-A22H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
TAT | SNV | Missense_Mutation | novel | c.185A>G | p.Asn62Ser | p.N62S | P17735 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TAT | SNV | Missense_Mutation | c.581G>T | p.Trp194Leu | p.W194L | P17735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
TAT | SNV | Missense_Mutation | c.744N>C | p.Glu248Asp | p.E248D | P17735 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-DR-A0ZL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6898 | TAT | ENZYME | TETRACYCLINE | TETRACYCLINE | 2154 | |
6898 | TAT | ENZYME | PROGESTERONE | PROGESTERONE | 9744518 | |
6898 | TAT | ENZYME | ALBUMIN | ALBUMIN HUMAN | 6127852 | |
6898 | TAT | ENZYME | ANDROGENS | 2882620 | ||
6898 | TAT | ENZYME | MITOMYCIN-C | 610 | ||
6898 | TAT | ENZYME | PREDNISOLONE | PREDNISOLONE | 6127207 | |
6898 | TAT | ENZYME | ENZYME INHIBITOR | 85301 | ||
6898 | TAT | ENZYME | PHENOBARBITAL | PHENOBARBITAL | 1688552 | |
6898 | TAT | ENZYME | VITAMIN A | 8100575 | ||
6898 | TAT | ENZYME | GENISTEIN | GENISTEIN | 9128187 |
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