Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HIPK2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HIPK2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HIPK2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HIPK2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/HIPK2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HIPK2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/HIPK2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HIPK2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HIPK2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HIPK2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043523110 | Thyroid | PTC | regulation of neuron apoptotic process | 102/5968 | 212/18723 | 5.45e-07 | 8.76e-06 | 102 |
GO:0048872113 | Thyroid | PTC | homeostasis of number of cells | 125/5968 | 272/18723 | 7.25e-07 | 1.14e-05 | 125 |
GO:2000059113 | Thyroid | PTC | negative regulation of ubiquitin-dependent protein catabolic process | 32/5968 | 48/18723 | 7.77e-07 | 1.20e-05 | 32 |
GO:001821017 | Thyroid | PTC | peptidyl-threonine modification | 66/5968 | 125/18723 | 9.50e-07 | 1.43e-05 | 66 |
GO:0051101113 | Thyroid | PTC | regulation of DNA binding | 63/5968 | 118/18723 | 1.00e-06 | 1.50e-05 | 63 |
GO:000717819 | Thyroid | PTC | transmembrane receptor protein serine/threonine kinase signaling pathway | 156/5968 | 355/18723 | 1.02e-06 | 1.51e-05 | 156 |
GO:0002262113 | Thyroid | PTC | myeloid cell homeostasis | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:001810717 | Thyroid | PTC | peptidyl-threonine phosphorylation | 62/5968 | 116/18723 | 1.16e-06 | 1.69e-05 | 62 |
GO:0030218113 | Thyroid | PTC | erythrocyte differentiation | 63/5968 | 120/18723 | 2.14e-06 | 2.89e-05 | 63 |
GO:0008630112 | Thyroid | PTC | intrinsic apoptotic signaling pathway in response to DNA damage | 54/5968 | 99/18723 | 2.46e-06 | 3.22e-05 | 54 |
GO:0031098111 | Thyroid | PTC | stress-activated protein kinase signaling cascade | 113/5968 | 247/18723 | 3.16e-06 | 4.10e-05 | 113 |
GO:0051403111 | Thyroid | PTC | stress-activated MAPK cascade | 108/5968 | 239/18723 | 1.02e-05 | 1.13e-04 | 108 |
GO:1903363112 | Thyroid | PTC | negative regulation of cellular protein catabolic process | 42/5968 | 75/18723 | 1.32e-05 | 1.43e-04 | 42 |
GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
GO:0071453112 | Thyroid | PTC | cellular response to oxygen levels | 83/5968 | 177/18723 | 2.01e-05 | 2.04e-04 | 83 |
GO:190121518 | Thyroid | PTC | negative regulation of neuron death | 95/5968 | 208/18723 | 2.01e-05 | 2.04e-04 | 95 |
GO:004277010 | Thyroid | PTC | signal transduction in response to DNA damage | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
GO:00069977 | Thyroid | PTC | nucleus organization | 65/5968 | 133/18723 | 3.16e-05 | 3.01e-04 | 65 |
GO:1903051112 | Thyroid | PTC | negative regulation of proteolysis involved in cellular protein catabolic process | 36/5968 | 64/18723 | 4.74e-05 | 4.26e-04 | 36 |
GO:005109016 | Thyroid | PTC | regulation of DNA-binding transcription factor activity | 178/5968 | 440/18723 | 7.63e-05 | 6.54e-04 | 178 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIPK2 | SNV | Missense_Mutation | | c.1945N>C | p.Asp649His | p.D649H | Q9H2X6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A7-A26H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD |
HIPK2 | SNV | Missense_Mutation | rs764542823 | c.350G>A | p.Arg117Gln | p.R117Q | Q9H2X6 | protein_coding | tolerated(0.2) | probably_damaging(0.978) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIPK2 | SNV | Missense_Mutation | novel | c.2665N>G | p.Thr889Ala | p.T889A | Q9H2X6 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
HIPK2 | SNV | Missense_Mutation | | c.1477N>A | p.Glu493Lys | p.E493K | Q9H2X6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD |
HIPK2 | SNV | Missense_Mutation | | c.2108C>G | p.Ala703Gly | p.A703G | Q9H2X6 | protein_coding | deleterious(0) | benign(0.108) | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
HIPK2 | SNV | Missense_Mutation | rs747709692 | c.280N>A | p.Val94Met | p.V94M | Q9H2X6 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
HIPK2 | SNV | Missense_Mutation | | c.47N>G | p.Ser16Cys | p.S16C | Q9H2X6 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
HIPK2 | SNV | Missense_Mutation | | c.2220N>C | p.Glu740Asp | p.E740D | Q9H2X6 | protein_coding | tolerated(0.99) | benign(0.001) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HIPK2 | SNV | Missense_Mutation | rs773782325 | c.140N>C | p.His47Pro | p.H47P | Q9H2X6 | protein_coding | tolerated(0.1) | possibly_damaging(0.71) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
HIPK2 | SNV | Missense_Mutation | rs773782325 | c.140N>C | p.His47Pro | p.H47P | Q9H2X6 | protein_coding | tolerated(0.1) | possibly_damaging(0.71) | TCGA-D8-A1JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | inhibitor | 249565808 | | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | TAMATINIB | R-406 | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | PI-103 | PI-103 | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | GSK-269962A | GSK-269962A | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | CENISERTIB | CENISERTIB | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | BAY-613606 | CHEMBL541400 | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | ILORASERTIB | ILORASERTIB | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | PF-562271 | PF-00562271 | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | PHA-767491 | CHEMBL225519 | |
28996 | HIPK2 | TYROSINE KINASE, SERINE THREONINE KINASE, TUMOR SUPPRESSOR, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, ENZYME | | SP-600125 | SP-600125 | |