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Gene: ZNF703 |
Gene summary for ZNF703 |
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Gene information | Species | Human | Gene symbol | ZNF703 | Gene ID | 80139 |
Gene name | zinc finger protein 703 | |
Gene Alias | NLZ1 | |
Cytomap | 8p11.23 | |
Gene Type | protein-coding | GO ID | GO:0001837 | UniProtAcc | Q9H7S9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80139 | ZNF703 | GSM4909286 | Human | Breast | IDC | 3.32e-03 | -1.22e-01 | 0.1081 |
80139 | ZNF703 | GSM4909297 | Human | Breast | IDC | 2.19e-06 | 3.88e-01 | 0.1517 |
80139 | ZNF703 | GSM4909298 | Human | Breast | IDC | 5.65e-09 | 2.47e-01 | 0.1551 |
80139 | ZNF703 | GSM4909301 | Human | Breast | IDC | 1.79e-03 | 2.44e-01 | 0.1577 |
80139 | ZNF703 | GSM4909303 | Human | Breast | IDC | 3.29e-02 | 3.28e-01 | 0.0438 |
80139 | ZNF703 | GSM4909304 | Human | Breast | IDC | 1.09e-15 | 4.76e-01 | 0.1636 |
80139 | ZNF703 | GSM4909305 | Human | Breast | IDC | 5.70e-05 | 3.07e-01 | 0.0436 |
80139 | ZNF703 | GSM4909306 | Human | Breast | IDC | 2.20e-15 | 4.80e-01 | 0.1564 |
80139 | ZNF703 | GSM4909307 | Human | Breast | IDC | 2.41e-05 | 3.32e-01 | 0.1569 |
80139 | ZNF703 | GSM4909308 | Human | Breast | IDC | 4.12e-26 | 5.67e-01 | 0.158 |
80139 | ZNF703 | GSM4909309 | Human | Breast | IDC | 2.10e-02 | 2.74e-01 | 0.0483 |
80139 | ZNF703 | GSM4909317 | Human | Breast | IDC | 5.80e-27 | 6.38e-01 | 0.1355 |
80139 | ZNF703 | GSM4909318 | Human | Breast | IDC | 3.54e-15 | 9.85e-01 | 0.2031 |
80139 | ZNF703 | GSM4909319 | Human | Breast | IDC | 1.00e-04 | 7.92e-02 | 0.1563 |
80139 | ZNF703 | M1 | Human | Breast | IDC | 4.54e-05 | 3.45e-01 | 0.1577 |
80139 | ZNF703 | NCCBC2 | Human | Breast | DCIS | 3.50e-22 | 1.25e+00 | 0.1554 |
80139 | ZNF703 | DCIS2 | Human | Breast | DCIS | 6.30e-10 | -4.17e-02 | 0.0085 |
80139 | ZNF703 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.97e-37 | 8.29e-01 | 0.0155 |
80139 | ZNF703 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.07e-18 | 6.89e-01 | -0.1808 |
80139 | ZNF703 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.08e-14 | 1.07e+00 | 0.0216 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00900921 | Colorectum | CRC | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 46/2078 | 256/18723 | 6.66e-04 | 8.77e-03 | 46 |
GO:00487622 | Colorectum | CRC | mesenchymal cell differentiation | 42/2078 | 236/18723 | 1.35e-03 | 1.50e-02 | 42 |
GO:00506733 | Colorectum | CRC | epithelial cell proliferation | 69/2078 | 437/18723 | 1.61e-03 | 1.69e-02 | 69 |
GO:00170151 | Colorectum | CRC | regulation of transforming growth factor beta receptor signaling pathway | 26/2078 | 128/18723 | 1.63e-03 | 1.70e-02 | 26 |
GO:00604851 | Colorectum | CRC | mesenchyme development | 49/2078 | 291/18723 | 1.94e-03 | 1.96e-02 | 49 |
GO:00018371 | Colorectum | CRC | epithelial to mesenchymal transition | 30/2078 | 157/18723 | 2.06e-03 | 2.05e-02 | 30 |
GO:19038441 | Colorectum | CRC | regulation of cellular response to transforming growth factor beta stimulus | 26/2078 | 131/18723 | 2.29e-03 | 2.20e-02 | 26 |
GO:00341101 | Colorectum | CRC | regulation of homotypic cell-cell adhesion | 10/2078 | 33/18723 | 2.32e-03 | 2.23e-02 | 10 |
GO:0032355 | Colorectum | CRC | response to estradiol | 27/2078 | 141/18723 | 3.24e-03 | 2.81e-02 | 27 |
GO:00308794 | Colorectum | CRC | mammary gland development | 26/2078 | 137/18723 | 4.32e-03 | 3.47e-02 | 26 |
GO:00335982 | Colorectum | CRC | mammary gland epithelial cell proliferation | 8/2078 | 26/18723 | 5.65e-03 | 4.24e-02 | 8 |
GO:00611803 | Colorectum | CRC | mammary gland epithelium development | 15/2078 | 67/18723 | 5.86e-03 | 4.33e-02 | 15 |
GO:0022407 | Colorectum | CRC | regulation of cell-cell adhesion | 67/2078 | 448/18723 | 6.86e-03 | 4.81e-02 | 67 |
GO:00071622 | Colorectum | CRC | negative regulation of cell adhesion | 48/2078 | 303/18723 | 7.14e-03 | 4.96e-02 | 48 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF703 | SNV | Missense_Mutation | novel | c.1642N>A | p.Tyr548Asn | p.Y548N | Q9H7S9 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-A7-A2KD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ZNF703 | SNV | Missense_Mutation | c.1136C>A | p.Pro379His | p.P379H | Q9H7S9 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF703 | SNV | Missense_Mutation | c.1138T>A | p.Tyr380Asn | p.Y380N | Q9H7S9 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF703 | SNV | Missense_Mutation | c.269C>T | p.Ala90Val | p.A90V | Q9H7S9 | protein_coding | deleterious(0.02) | possibly_damaging(0.707) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF703 | SNV | Missense_Mutation | novel | c.343G>A | p.Ala115Thr | p.A115T | Q9H7S9 | protein_coding | tolerated(0.12) | benign(0.069) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF703 | SNV | Missense_Mutation | c.1441N>A | p.Leu481Ile | p.L481I | Q9H7S9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
ZNF703 | SNV | Missense_Mutation | c.1558C>A | p.Leu520Ile | p.L520I | Q9H7S9 | protein_coding | tolerated(0.52) | benign(0.188) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF703 | SNV | Missense_Mutation | rs775245530 | c.1723N>A | p.Ala575Thr | p.A575T | Q9H7S9 | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AG-3598-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF703 | SNV | Missense_Mutation | novel | c.1659N>C | p.Leu553Phe | p.L553F | Q9H7S9 | protein_coding | deleterious(0) | benign(0.175) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF703 | SNV | Missense_Mutation | novel | c.1043G>A | p.Gly348Glu | p.G348E | Q9H7S9 | protein_coding | tolerated(0.05) | probably_damaging(0.995) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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