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Gene: WDR1 |
Gene summary for WDR1 |
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Gene information | Species | Human | Gene symbol | WDR1 | Gene ID | 9948 |
Gene name | WD repeat domain 1 | |
Gene Alias | AIP1 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75083 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9948 | WDR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.50e-12 | 7.03e-01 | -0.1808 |
9948 | WDR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.16e-12 | 7.43e-01 | -0.0811 |
9948 | WDR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.16e-09 | 5.47e-01 | -0.1088 |
9948 | WDR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-26 | 7.52e-01 | -0.1954 |
9948 | WDR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.94e-10 | 1.37e+00 | -0.2602 |
9948 | WDR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.18e-05 | 8.15e-01 | -0.2196 |
9948 | WDR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-02 | 4.03e-01 | -0.1207 |
9948 | WDR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.23e-05 | 6.57e-01 | -0.1526 |
9948 | WDR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.50e-17 | 6.21e-01 | -0.1464 |
9948 | WDR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.94e-05 | 2.52e-01 | -0.1001 |
9948 | WDR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.98e-15 | 8.14e-01 | -0.059 |
9948 | WDR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.65e-09 | 1.11e+00 | -0.1706 |
9948 | WDR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.39e-06 | 7.70e-01 | -0.2061 |
9948 | WDR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.04e-02 | 3.81e-01 | -0.0179 |
9948 | WDR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.23e-09 | 4.61e-01 | 0.096 |
9948 | WDR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.16e-02 | 4.75e-01 | -0.0177 |
9948 | WDR1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.82e-05 | 8.33e-01 | 0.0171 |
9948 | WDR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-10 | 4.19e-01 | 0.0674 |
9948 | WDR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.51e-15 | 4.73e-01 | 0.294 |
9948 | WDR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.57e-10 | 5.91e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:00300422 | Colorectum | MSS | actin filament depolymerization | 22/3467 | 59/18723 | 5.35e-04 | 6.02e-03 | 22 |
GO:00308342 | Colorectum | MSS | regulation of actin filament depolymerization | 20/3467 | 54/18723 | 1.04e-03 | 1.03e-02 | 20 |
GO:00310322 | Colorectum | MSS | actomyosin structure organization | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
GO:00510523 | Colorectum | MSI-H | regulation of DNA metabolic process | 45/1319 | 359/18723 | 1.20e-04 | 3.56e-03 | 45 |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
GO:0006260 | Colorectum | MSI-H | DNA replication | 31/1319 | 260/18723 | 2.83e-03 | 3.63e-02 | 31 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR1 | SNV | Missense_Mutation | novel | c.1043N>G | p.Tyr348Cys | p.Y348C | O75083 | protein_coding | tolerated(0.14) | possibly_damaging(0.807) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | novel | c.1041N>G | p.Asn347Lys | p.N347K | O75083 | protein_coding | tolerated(0.3) | possibly_damaging(0.739) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | c.1606N>C | p.Val536Leu | p.V536L | O75083 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR1 | deletion | Frame_Shift_Del | novel | c.748delN | p.Leu250PhefsTer16 | p.L250Ffs*16 | O75083 | protein_coding | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |||
WDR1 | SNV | Missense_Mutation | novel | c.532C>T | p.Pro178Ser | p.P178S | O75083 | protein_coding | deleterious(0) | benign(0.03) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs545497657 | c.700G>A | p.Asp234Asn | p.D234N | O75083 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs868174972 | c.200N>T | p.Ala67Val | p.A67V | O75083 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR1 | SNV | Missense_Mutation | novel | c.638N>C | p.Ile213Thr | p.I213T | O75083 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
WDR1 | SNV | Missense_Mutation | c.1319N>A | p.Ser440Asn | p.S440N | O75083 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR1 | SNV | Missense_Mutation | rs370326840 | c.1222G>A | p.Val408Ile | p.V408I | O75083 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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