Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/VPS4B_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/VPS4B_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/VPS4B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/VPS4B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/VPS4B_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/VPS4B_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/VPS4B_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/VPS4B_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19048961 | Colorectum | SER | ESCRT complex disassembly | 6/2897 | 10/18723 | 1.63e-03 | 1.72e-02 | 6 |
GO:19049031 | Colorectum | SER | ESCRT III complex disassembly | 6/2897 | 10/18723 | 1.63e-03 | 1.72e-02 | 6 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00619521 | Colorectum | SER | midbody abscission | 8/2897 | 17/18723 | 2.12e-03 | 2.06e-02 | 8 |
GO:0010824 | Colorectum | SER | regulation of centrosome duplication | 15/2897 | 45/18723 | 2.29e-03 | 2.19e-02 | 15 |
GO:00901691 | Colorectum | SER | regulation of spindle assembly | 10/2897 | 25/18723 | 2.70e-03 | 2.44e-02 | 10 |
GO:0090224 | Colorectum | SER | regulation of spindle organization | 13/2897 | 39/18723 | 4.39e-03 | 3.51e-02 | 13 |
GO:00602361 | Colorectum | SER | regulation of mitotic spindle organization | 12/2897 | 35/18723 | 4.72e-03 | 3.71e-02 | 12 |
GO:1903531 | Colorectum | SER | negative regulation of secretion by cell | 35/2897 | 147/18723 | 5.21e-03 | 3.95e-02 | 35 |
GO:00510471 | Colorectum | SER | positive regulation of secretion | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00171571 | Colorectum | SER | regulation of exocytosis | 45/2897 | 202/18723 | 6.46e-03 | 4.63e-02 | 45 |
GO:0051048 | Colorectum | SER | negative regulation of secretion | 39/2897 | 171/18723 | 7.17e-03 | 4.99e-02 | 39 |
GO:00160324 | Colorectum | FAP | viral process | 114/2622 | 415/18723 | 3.00e-13 | 2.63e-10 | 114 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00190584 | Colorectum | FAP | viral life cycle | 81/2622 | 317/18723 | 2.97e-08 | 2.64e-06 | 81 |
GO:00514954 | Colorectum | FAP | positive regulation of cytoskeleton organization | 60/2622 | 226/18723 | 4.45e-07 | 2.37e-05 | 60 |
GO:00160503 | Colorectum | FAP | vesicle organization | 74/2622 | 300/18723 | 5.16e-07 | 2.66e-05 | 74 |
GO:00162363 | Colorectum | FAP | macroautophagy | 70/2622 | 291/18723 | 2.73e-06 | 1.02e-04 | 70 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00161973 | Colorectum | FAP | endosomal transport | 56/2622 | 230/18723 | 1.79e-05 | 4.53e-04 | 56 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VPS4B | SNV | Missense_Mutation | rs142699030 | c.406G>A | p.Val136Ile | p.V136I | O75351 | protein_coding | tolerated(0.23) | benign(0.06) | TCGA-A2-A0T7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
VPS4B | SNV | Missense_Mutation | | c.1070N>C | p.Gln357Pro | p.Q357P | O75351 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
VPS4B | SNV | Missense_Mutation | | c.409N>C | p.Ala137Pro | p.A137P | O75351 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
VPS4B | SNV | Missense_Mutation | rs771753062 | c.82N>A | p.Glu28Lys | p.E28K | O75351 | protein_coding | tolerated(0.1) | benign(0.038) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VPS4B | SNV | Missense_Mutation | | c.878A>C | p.Glu293Ala | p.E293A | O75351 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
VPS4B | SNV | Missense_Mutation | rs753852708 | c.755N>A | p.Arg252His | p.R252H | O75351 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0BQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
VPS4B | SNV | Missense_Mutation | | c.1293N>T | p.Leu431Phe | p.L431F | O75351 | protein_coding | deleterious(0.03) | benign(0.186) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
VPS4B | insertion | Nonsense_Mutation | novel | c.223_224insGAC | p.Tyr75delinsTer | p.Y75delins* | O75351 | protein_coding | | | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
VPS4B | insertion | Nonsense_Mutation | novel | c.222_223insCCATAGTTTGC | p.Tyr75ProfsTer2 | p.Y75Pfs*2 | O75351 | protein_coding | | | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
VPS4B | SNV | Missense_Mutation | | c.128A>G | p.His43Arg | p.H43R | O75351 | protein_coding | tolerated(0.35) | possibly_damaging(0.782) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |