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Gene: VAMP8 |
Gene summary for VAMP8 |
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Gene information | Species | Human | Gene symbol | VAMP8 | Gene ID | 8673 |
Gene name | vesicle associated membrane protein 8 | |
Gene Alias | EDB | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9BV40 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8673 | VAMP8 | CA_HPV_1 | Human | Cervix | CC | 2.02e-09 | 1.13e-01 | 0.0264 |
8673 | VAMP8 | CA_HPV_3 | Human | Cervix | CC | 1.90e-04 | 4.12e-02 | 0.0414 |
8673 | VAMP8 | CCI_1 | Human | Cervix | CC | 1.49e-11 | -9.00e-01 | 0.528 |
8673 | VAMP8 | CCI_3 | Human | Cervix | CC | 8.00e-16 | -9.31e-01 | 0.516 |
8673 | VAMP8 | CCII_1 | Human | Cervix | CC | 3.12e-24 | -9.71e-01 | 0.3249 |
8673 | VAMP8 | sample1 | Human | Cervix | CC | 4.83e-04 | -5.50e-01 | 0.0959 |
8673 | VAMP8 | sample3 | Human | Cervix | CC | 1.02e-05 | 1.36e-01 | 0.1387 |
8673 | VAMP8 | T1 | Human | Cervix | CC | 1.44e-14 | -6.21e-01 | 0.0918 |
8673 | VAMP8 | T3 | Human | Cervix | CC | 1.89e-02 | 1.42e-01 | 0.1389 |
8673 | VAMP8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.13e-09 | 2.62e-01 | 0.0155 |
8673 | VAMP8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.87e-37 | 1.57e+00 | -0.1808 |
8673 | VAMP8 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 4.09e-01 | 0.0216 |
8673 | VAMP8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.85e-21 | 9.68e-01 | -0.0811 |
8673 | VAMP8 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.21e-05 | 2.84e-01 | -0.1088 |
8673 | VAMP8 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.43e-36 | 9.15e-01 | -0.1954 |
8673 | VAMP8 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.64e-20 | 2.26e+00 | -0.2602 |
8673 | VAMP8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.76e-16 | 1.68e+00 | -0.2196 |
8673 | VAMP8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-16 | 7.48e-01 | -0.1207 |
8673 | VAMP8 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.59e-20 | 1.04e+00 | -0.1526 |
8673 | VAMP8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.24e-43 | 1.16e+00 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00517012 | Colorectum | MSS | biological process involved in interaction with host | 67/3467 | 203/18723 | 5.13e-07 | 1.98e-05 | 67 |
GO:00521262 | Colorectum | MSS | movement in host environment | 58/3467 | 175/18723 | 2.50e-06 | 7.64e-05 | 58 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00467182 | Colorectum | MSS | viral entry into host cell | 47/3467 | 144/18723 | 3.35e-05 | 6.56e-04 | 47 |
GO:00444092 | Colorectum | MSS | entry into host | 47/3467 | 151/18723 | 1.24e-04 | 1.91e-03 | 47 |
GO:00508782 | Colorectum | MSS | regulation of body fluid levels | 99/3467 | 379/18723 | 1.40e-04 | 2.07e-03 | 99 |
GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
GO:00224062 | Colorectum | MSS | membrane docking | 28/3467 | 86/18723 | 1.27e-03 | 1.21e-02 | 28 |
GO:00075892 | Colorectum | MSS | body fluid secretion | 29/3467 | 93/18723 | 2.21e-03 | 1.84e-02 | 29 |
GO:01400562 | Colorectum | MSS | organelle localization by membrane tethering | 25/3467 | 77/18723 | 2.34e-03 | 1.91e-02 | 25 |
GO:00459212 | Colorectum | MSS | positive regulation of exocytosis | 27/3467 | 86/18723 | 2.76e-03 | 2.17e-02 | 27 |
GO:00510511 | Colorectum | MSS | negative regulation of transport | 110/3467 | 470/18723 | 4.20e-03 | 3.04e-02 | 110 |
GO:00482841 | Colorectum | MSS | organelle fusion | 39/3467 | 141/18723 | 4.91e-03 | 3.42e-02 | 39 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046115 | Cervix | CC | Platelet activation | 28/1267 | 124/8465 | 1.50e-02 | 4.45e-02 | 2.63e-02 | 28 |
hsa0461113 | Cervix | CC | Platelet activation | 28/1267 | 124/8465 | 1.50e-02 | 4.45e-02 | 2.63e-02 | 28 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa04130 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa041301 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VAMP8 | SNV | Missense_Mutation | c.68N>A | p.Val23Asp | p.V23D | Q9BV40 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
VAMP8 | SNV | Missense_Mutation | c.286N>G | p.Thr96Ala | p.T96A | Q9BV40 | protein_coding | deleterious(0.02) | benign(0.18) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
VAMP8 | SNV | Missense_Mutation | novel | c.233T>C | p.Val78Ala | p.V78A | Q9BV40 | protein_coding | tolerated(0.13) | benign(0.207) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | novel | c.235N>A | p.Leu79Ile | p.L79I | Q9BV40 | protein_coding | tolerated(0.91) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | c.71A>C | p.Lys24Thr | p.K24T | Q9BV40 | protein_coding | tolerated(0.09) | possibly_damaging(0.721) | TCGA-AP-A0L9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VAMP8 | SNV | Missense_Mutation | novel | c.287C>T | p.Thr96Ile | p.T96I | Q9BV40 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | c.224N>T | p.Lys75Met | p.K75M | Q9BV40 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BG-A0LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VAMP8 | SNV | Missense_Mutation | rs766364692 | c.220N>A | p.Val74Met | p.V74M | Q9BV40 | protein_coding | tolerated(0.08) | benign(0.053) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | novel | c.101T>C | p.Ile34Thr | p.I34T | Q9BV40 | protein_coding | tolerated(0.08) | benign(0.425) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VAMP8 | deletion | Frame_Shift_Del | rs774807701 | c.110delN | p.Glu39LysfsTer36 | p.E39Kfs*36 | Q9BV40 | protein_coding | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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