Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UTRN

Gene summary for UTRN

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UTRN

Gene ID

7402

Gene nameutrophin
Gene AliasDMDL
Cytomap6q24.2
Gene Typeprotein-coding
GO ID

GO:0001952

UniProtAcc

P46939


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7402UTRNCCI_1HumanCervixCC4.78e-049.71e-010.528
7402UTRNCCI_3HumanCervixCC5.68e-087.88e-010.516
7402UTRNL1HumanCervixCC3.10e-03-2.46e-010.0802
7402UTRNHTA11_3410_2000001011HumanColorectumAD5.66e-43-7.90e-010.0155
7402UTRNHTA11_2487_2000001011HumanColorectumSER2.88e-18-7.76e-01-0.1808
7402UTRNHTA11_2951_2000001011HumanColorectumAD1.95e-13-1.21e+000.0216
7402UTRNHTA11_1938_2000001011HumanColorectumAD1.84e-10-5.27e-01-0.0811
7402UTRNHTA11_78_2000001011HumanColorectumAD2.50e-07-4.74e-01-0.1088
7402UTRNHTA11_2112_2000001011HumanColorectumSER1.37e-05-8.78e-01-0.2196
7402UTRNHTA11_3361_2000001011HumanColorectumAD1.98e-25-9.25e-01-0.1207
7402UTRNHTA11_83_2000001011HumanColorectumSER5.06e-06-4.58e-01-0.1526
7402UTRNHTA11_696_2000001011HumanColorectumAD3.21e-12-5.32e-01-0.1464
7402UTRNHTA11_866_2000001011HumanColorectumAD7.70e-07-5.10e-01-0.1001
7402UTRNHTA11_1391_2000001011HumanColorectumAD1.08e-08-4.78e-01-0.059
7402UTRNHTA11_2992_2000001011HumanColorectumSER1.16e-05-6.89e-01-0.1706
7402UTRNHTA11_5212_2000001011HumanColorectumAD1.04e-15-9.73e-01-0.2061
7402UTRNHTA11_5216_2000001011HumanColorectumSER1.38e-04-6.89e-01-0.1462
7402UTRNHTA11_546_2000001011HumanColorectumAD2.03e-04-4.64e-01-0.0842
7402UTRNHTA11_9341_2000001011HumanColorectumSER2.47e-04-8.02e-01-0.00410000000000005
7402UTRNHTA11_866_3004761011HumanColorectumAD3.30e-19-6.34e-010.096
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190230510EndometriumAEHregulation of sodium ion transmembrane transport16/210068/187232.96e-032.11e-0216
GO:00228986EndometriumAEHregulation of transmembrane transporter activity45/2100278/187237.34e-034.18e-0245
GO:19040623EndometriumAEHregulation of cation transmembrane transport55/2100357/187239.18e-034.96e-0255
GO:001081016EndometriumEECregulation of cell-substrate adhesion63/2168221/187235.17e-128.85e-1063
GO:003158915EndometriumEECcell-substrate adhesion87/2168363/187231.95e-113.00e-0987
GO:004578517EndometriumEECpositive regulation of cell adhesion98/2168437/187236.15e-118.38e-0998
GO:001081117EndometriumEECpositive regulation of cell-substrate adhesion37/2168123/187232.59e-081.51e-0637
GO:000195213EndometriumEECregulation of cell-matrix adhesion37/2168128/187238.21e-084.23e-0637
GO:000716014EndometriumEECcell-matrix adhesion54/2168233/187233.98e-071.56e-0554
GO:000195414EndometriumEECpositive regulation of cell-matrix adhesion18/216858/187236.08e-059.21e-0418
GO:000301213EndometriumEECmuscle system process79/2168452/187231.16e-041.55e-0379
GO:000751712EndometriumEECmuscle organ development59/2168327/187233.49e-043.85e-0359
GO:001095914EndometriumEECregulation of metal ion transport70/2168406/187234.12e-044.35e-0370
GO:00069361EndometriumEECmuscle contraction59/2168347/187231.57e-031.26e-0259
GO:00020289EndometriumEECregulation of sodium ion transport20/216890/187232.92e-032.06e-0220
GO:190230513EndometriumEECregulation of sodium ion transmembrane transport16/216868/187234.08e-032.68e-0216
GO:003158919EsophagusESCCcell-substrate adhesion221/8552363/187233.06e-096.62e-08221
GO:001081020EsophagusESCCregulation of cell-substrate adhesion144/8552221/187233.55e-097.45e-08144
GO:004578527EsophagusESCCpositive regulation of cell adhesion255/8552437/187235.07e-089.11e-07255
GO:001081126EsophagusESCCpositive regulation of cell-substrate adhesion84/8552123/187233.18e-074.50e-0684
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UTRNSNVMissense_Mutationnovelc.8216G>Cp.Arg2739Thrp.R2739TP46939protein_codingdeleterious(0)benign(0.153)TCGA-3C-AALI-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPoly EComplete Response
UTRNSNVMissense_Mutationc.4951N>Gp.Gln1651Glup.Q1651EP46939protein_codingdeleterious(0.01)probably_damaging(0.965)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
UTRNSNVMissense_Mutationnovelc.2422G>Cp.Asp808Hisp.D808HP46939protein_codingtolerated(0.06)benign(0.352)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
UTRNSNVMissense_Mutationc.8662G>Ap.Glu2888Lysp.E2888KP46939protein_codingdeleterious(0.02)benign(0.087)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
UTRNSNVMissense_Mutationc.2248N>Gp.Gln750Glup.Q750EP46939protein_codingtolerated(0.09)benign(0.034)TCGA-A8-A07U-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
UTRNSNVMissense_Mutationc.5062N>Cp.Glu1688Glnp.E1688QP46939protein_codingdeleterious(0.04)benign(0.246)TCGA-A8-A094-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UTRNSNVMissense_Mutationc.9578G>Cp.Arg3193Thrp.R3193TP46939protein_codingdeleterious(0)probably_damaging(0.955)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
UTRNSNVMissense_Mutationc.2587N>Cp.Ser863Prop.S863PP46939protein_codingtolerated(0.26)benign(0.037)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UTRNSNVMissense_Mutationnovelc.8603N>Cp.Lys2868Thrp.K2868TP46939protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
UTRNSNVMissense_Mutationc.9787N>Gp.Leu3263Valp.L3263VP46939protein_codingdeleterious(0)probably_damaging(0.977)TCGA-AR-A251-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
7402UTRNNAENZYME INHIBITOR15639474
7402UTRNNASMT-C1100EZUTROMID
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