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Gene: USP14 |
Gene summary for USP14 |
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Gene information | Species | Human | Gene symbol | USP14 | Gene ID | 9097 |
Gene name | ubiquitin specific peptidase 14 | |
Gene Alias | TGT | |
Cytomap | 18p11.32 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P54578 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9097 | USP14 | GSM4909287 | Human | Breast | IDC | 2.36e-07 | 4.04e-01 | 0.2057 |
9097 | USP14 | GSM4909291 | Human | Breast | IDC | 3.60e-05 | 4.08e-01 | 0.1753 |
9097 | USP14 | GSM4909293 | Human | Breast | IDC | 2.13e-22 | 5.00e-01 | 0.1581 |
9097 | USP14 | GSM4909296 | Human | Breast | IDC | 1.86e-02 | -1.04e-01 | 0.1524 |
9097 | USP14 | GSM4909311 | Human | Breast | IDC | 1.12e-06 | -1.85e-01 | 0.1534 |
9097 | USP14 | GSM4909312 | Human | Breast | IDC | 1.06e-02 | -1.62e-01 | 0.1552 |
9097 | USP14 | GSM4909319 | Human | Breast | IDC | 4.32e-10 | -1.33e-01 | 0.1563 |
9097 | USP14 | brca2 | Human | Breast | Precancer | 5.30e-05 | 1.68e-01 | -0.024 |
9097 | USP14 | P1 | Human | Breast | IDC | 1.71e-02 | 1.58e-02 | 0.1527 |
9097 | USP14 | DCIS2 | Human | Breast | DCIS | 4.49e-59 | 2.92e-01 | 0.0085 |
9097 | USP14 | LZE2T | Human | Esophagus | ESCC | 5.73e-14 | 2.38e+00 | 0.082 |
9097 | USP14 | LZE3D | Human | Esophagus | HGIN | 2.75e-02 | 4.34e-01 | 0.0668 |
9097 | USP14 | LZE4T | Human | Esophagus | ESCC | 2.91e-10 | 4.23e-01 | 0.0811 |
9097 | USP14 | LZE7T | Human | Esophagus | ESCC | 1.67e-05 | 6.25e-01 | 0.0667 |
9097 | USP14 | LZE8T | Human | Esophagus | ESCC | 5.28e-10 | 3.19e-02 | 0.067 |
9097 | USP14 | LZE20T | Human | Esophagus | ESCC | 7.72e-08 | 1.37e-01 | 0.0662 |
9097 | USP14 | LZE24T | Human | Esophagus | ESCC | 2.72e-14 | 4.40e-01 | 0.0596 |
9097 | USP14 | LZE21T | Human | Esophagus | ESCC | 8.77e-07 | 3.78e-01 | 0.0655 |
9097 | USP14 | LZE6T | Human | Esophagus | ESCC | 1.05e-10 | 5.51e-01 | 0.0845 |
9097 | USP14 | P1T-E | Human | Esophagus | ESCC | 3.46e-09 | 4.80e-01 | 0.0875 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001046620 | Esophagus | ESCC | negative regulation of peptidase activity | 140/8552 | 262/18723 | 6.73e-03 | 2.46e-02 | 140 |
GO:001095119 | Esophagus | ESCC | negative regulation of endopeptidase activity | 135/8552 | 252/18723 | 6.86e-03 | 2.51e-02 | 135 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:004217622 | Liver | HCC | regulation of protein catabolic process | 267/7958 | 391/18723 | 2.45e-25 | 7.38e-23 | 267 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:190336222 | Liver | HCC | regulation of cellular protein catabolic process | 182/7958 | 255/18723 | 5.91e-21 | 8.52e-19 | 182 |
GO:190305022 | Liver | HCC | regulation of proteolysis involved in cellular protein catabolic process | 157/7958 | 221/18723 | 5.93e-18 | 6.83e-16 | 157 |
GO:003650311 | Liver | HCC | ERAD pathway | 88/7958 | 107/18723 | 2.87e-17 | 2.85e-15 | 88 |
GO:006113622 | Liver | HCC | regulation of proteasomal protein catabolic process | 134/7958 | 187/18723 | 5.03e-16 | 4.09e-14 | 134 |
GO:00304331 | Liver | HCC | ubiquitin-dependent ERAD pathway | 72/7958 | 85/18723 | 9.78e-16 | 7.47e-14 | 72 |
GO:200005822 | Liver | HCC | regulation of ubiquitin-dependent protein catabolic process | 120/7958 | 164/18723 | 1.31e-15 | 9.74e-14 | 120 |
GO:003243422 | Liver | HCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/7958 | 134/18723 | 3.67e-14 | 2.32e-12 | 100 |
GO:000989522 | Liver | HCC | negative regulation of catabolic process | 196/7958 | 320/18723 | 7.98e-12 | 3.35e-10 | 196 |
GO:003133022 | Liver | HCC | negative regulation of cellular catabolic process | 164/7958 | 262/18723 | 3.52e-11 | 1.35e-09 | 164 |
GO:190589712 | Liver | HCC | regulation of response to endoplasmic reticulum stress | 62/7958 | 82/18723 | 1.06e-09 | 3.23e-08 | 62 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:190357312 | Liver | HCC | negative regulation of response to endoplasmic reticulum stress | 35/7958 | 44/18723 | 5.70e-07 | 9.03e-06 | 35 |
GO:005254722 | Liver | HCC | regulation of peptidase activity | 247/7958 | 461/18723 | 8.28e-07 | 1.27e-05 | 247 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP14 | SNV | Missense_Mutation | novel | c.1482N>C | p.Gln494His | p.Q494H | P54578 | protein_coding | tolerated_low_confidence(0.23) | benign(0.005) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP14 | insertion | In_Frame_Ins | novel | c.1484_1485insACAGGAGAACCC | p.Ter495delinsTer | p.*495delins* | P54578 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USP14 | deletion | Frame_Shift_Del | novel | c.874delN | p.Leu292CysfsTer33 | p.L292Cfs*33 | P54578 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
USP14 | SNV | Missense_Mutation | rs374300842 | c.760N>G | p.Thr254Ala | p.T254A | P54578 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
USP14 | SNV | Missense_Mutation | c.40N>C | p.Lys14Gln | p.K14Q | P54578 | protein_coding | tolerated(0.13) | possibly_damaging(0.823) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP14 | SNV | Missense_Mutation | c.911N>T | p.Thr304Met | p.T304M | P54578 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
USP14 | SNV | Missense_Mutation | novel | c.288N>T | p.Gln96His | p.Q96H | P54578 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP14 | insertion | Nonsense_Mutation | novel | c.286_287insACATATAACATAATTCT | p.Gln96HisfsTer3 | p.Q96Hfs*3 | P54578 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
USP14 | insertion | Frame_Shift_Ins | novel | c.990_991insT | p.Tyr333LeufsTer2 | p.Y333Lfs*2 | P54578 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
USP14 | SNV | Missense_Mutation | novel | c.1384N>T | p.Asp462Tyr | p.D462Y | P54578 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 252827537 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | PMID26077642-Compound-Figure3A | |||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 328083515 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | Tricyclic heterocycle derivative 4 |
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