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Gene: TWSG1 |
Gene summary for TWSG1 |
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Gene information | Species | Human | Gene symbol | TWSG1 | Gene ID | 57045 |
Gene name | twisted gastrulation BMP signaling modulator 1 | |
Gene Alias | TSG | |
Cytomap | 18p11.22 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9GZX9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57045 | TWSG1 | LZE2T | Human | Esophagus | ESCC | 9.37e-05 | 9.51e-01 | 0.082 |
57045 | TWSG1 | LZE7T | Human | Esophagus | ESCC | 2.00e-02 | 3.81e-01 | 0.0667 |
57045 | TWSG1 | LZE22T | Human | Esophagus | ESCC | 3.21e-03 | 9.72e-02 | 0.068 |
57045 | TWSG1 | LZE24T | Human | Esophagus | ESCC | 1.38e-12 | 4.23e-01 | 0.0596 |
57045 | TWSG1 | LZE6T | Human | Esophagus | ESCC | 2.90e-03 | -6.91e-03 | 0.0845 |
57045 | TWSG1 | P1T-E | Human | Esophagus | ESCC | 3.49e-06 | 1.71e-01 | 0.0875 |
57045 | TWSG1 | P2T-E | Human | Esophagus | ESCC | 7.07e-27 | 7.35e-01 | 0.1177 |
57045 | TWSG1 | P4T-E | Human | Esophagus | ESCC | 1.48e-24 | 5.70e-01 | 0.1323 |
57045 | TWSG1 | P5T-E | Human | Esophagus | ESCC | 4.20e-09 | 3.46e-01 | 0.1327 |
57045 | TWSG1 | P8T-E | Human | Esophagus | ESCC | 9.96e-17 | 3.12e-01 | 0.0889 |
57045 | TWSG1 | P9T-E | Human | Esophagus | ESCC | 1.57e-12 | 1.39e-01 | 0.1131 |
57045 | TWSG1 | P10T-E | Human | Esophagus | ESCC | 6.06e-09 | 1.77e-01 | 0.116 |
57045 | TWSG1 | P11T-E | Human | Esophagus | ESCC | 2.06e-06 | 5.16e-01 | 0.1426 |
57045 | TWSG1 | P12T-E | Human | Esophagus | ESCC | 4.95e-31 | 7.79e-01 | 0.1122 |
57045 | TWSG1 | P15T-E | Human | Esophagus | ESCC | 6.06e-10 | 2.56e-01 | 0.1149 |
57045 | TWSG1 | P16T-E | Human | Esophagus | ESCC | 5.85e-19 | 4.26e-01 | 0.1153 |
57045 | TWSG1 | P20T-E | Human | Esophagus | ESCC | 5.88e-12 | 2.22e-01 | 0.1124 |
57045 | TWSG1 | P21T-E | Human | Esophagus | ESCC | 5.33e-28 | 4.34e-01 | 0.1617 |
57045 | TWSG1 | P22T-E | Human | Esophagus | ESCC | 1.96e-24 | 4.93e-01 | 0.1236 |
57045 | TWSG1 | P23T-E | Human | Esophagus | ESCC | 1.76e-27 | 7.51e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240724 | Oral cavity | NEOLP | regulation of cell-cell adhesion | 81/2005 | 448/18723 | 1.54e-06 | 3.83e-05 | 81 |
GO:000715923 | Oral cavity | NEOLP | leukocyte cell-cell adhesion | 70/2005 | 371/18723 | 1.65e-06 | 4.05e-05 | 70 |
GO:004211031 | Oral cavity | NEOLP | T cell activation | 86/2005 | 487/18723 | 2.01e-06 | 4.77e-05 | 86 |
GO:01500631 | Oral cavity | NEOLP | visual system development | 70/2005 | 375/18723 | 2.46e-06 | 5.64e-05 | 70 |
GO:000165411 | Oral cavity | NEOLP | eye development | 69/2005 | 371/18723 | 3.30e-06 | 7.40e-05 | 69 |
GO:00488801 | Oral cavity | NEOLP | sensory system development | 70/2005 | 381/18723 | 4.38e-06 | 9.42e-05 | 70 |
GO:00901011 | Oral cavity | NEOLP | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 32/2005 | 131/18723 | 5.88e-06 | 1.19e-04 | 32 |
GO:000164931 | Oral cavity | NEOLP | osteoblast differentiation | 47/2005 | 229/18723 | 8.59e-06 | 1.66e-04 | 47 |
GO:004873232 | Oral cavity | NEOLP | gland development | 76/2005 | 436/18723 | 1.25e-05 | 2.25e-04 | 76 |
GO:000716223 | Oral cavity | NEOLP | negative regulation of cell adhesion | 57/2005 | 303/18723 | 1.62e-05 | 2.79e-04 | 57 |
GO:003090013 | Oral cavity | NEOLP | forebrain development | 67/2005 | 379/18723 | 2.54e-05 | 3.99e-04 | 67 |
GO:190303723 | Oral cavity | NEOLP | regulation of leukocyte cell-cell adhesion | 61/2005 | 336/18723 | 2.56e-05 | 4.01e-04 | 61 |
GO:009028711 | Oral cavity | NEOLP | regulation of cellular response to growth factor stimulus | 56/2005 | 304/18723 | 3.55e-05 | 5.20e-04 | 56 |
GO:009009213 | Oral cavity | NEOLP | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 49/2005 | 256/18723 | 3.90e-05 | 5.62e-04 | 49 |
GO:000736921 | Oral cavity | NEOLP | gastrulation | 38/2005 | 185/18723 | 5.90e-05 | 7.93e-04 | 38 |
GO:000268331 | Oral cavity | NEOLP | negative regulation of immune system process | 73/2005 | 434/18723 | 6.18e-05 | 8.22e-04 | 73 |
GO:000170421 | Oral cavity | NEOLP | formation of primary germ layer | 28/2005 | 121/18723 | 6.25e-05 | 8.31e-04 | 28 |
GO:005086323 | Oral cavity | NEOLP | regulation of T cell activation | 58/2005 | 329/18723 | 9.33e-05 | 1.15e-03 | 58 |
GO:007066122 | Oral cavity | NEOLP | leukocyte proliferation | 55/2005 | 318/18723 | 2.32e-04 | 2.41e-03 | 55 |
GO:0043010 | Oral cavity | NEOLP | camera-type eye development | 55/2005 | 322/18723 | 3.20e-04 | 3.11e-03 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TWSG1 | SNV | Missense_Mutation | c.155A>T | p.Asn52Ile | p.N52I | Q9GZX9 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.331G>C | p.Asp111His | p.D111H | Q9GZX9 | protein_coding | tolerated(0.08) | benign(0.05) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TWSG1 | deletion | Frame_Shift_Del | novel | c.534delN | p.His179IlefsTer41 | p.H179Ifs*41 | Q9GZX9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TWSG1 | SNV | Missense_Mutation | rs376720221 | c.226N>G | p.Met76Val | p.M76V | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.07) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TWSG1 | SNV | Missense_Mutation | c.521N>G | p.Asp174Gly | p.D174G | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.233) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.307N>A | p.Leu103Ile | p.L103I | Q9GZX9 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TWSG1 | SNV | Missense_Mutation | c.251N>T | p.Asp84Val | p.D84V | Q9GZX9 | protein_coding | deleterious(0.03) | possibly_damaging(0.494) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.454N>G | p.Ser152Gly | p.S152G | Q9GZX9 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
TWSG1 | SNV | Missense_Mutation | novel | c.393G>T | p.Glu131Asp | p.E131D | Q9GZX9 | protein_coding | tolerated(0.13) | benign(0.424) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TWSG1 | SNV | Missense_Mutation | c.325N>C | p.Glu109Gln | p.E109Q | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-CI-6620-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Ancillary | leucovorin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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