Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TMEM109_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TMEM109_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TMEM109_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TMEM109_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TMEM109_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007148018 | Thyroid | PTC | cellular response to gamma radiation | 22/5968 | 31/18723 | 9.07e-06 | 1.03e-04 | 22 |
GO:00103329 | Thyroid | PTC | response to gamma radiation | 32/5968 | 56/18723 | 8.16e-05 | 6.94e-04 | 32 |
GO:009719335 | Thyroid | ATC | intrinsic apoptotic signaling pathway | 171/6293 | 288/18723 | 1.86e-19 | 2.67e-17 | 171 |
GO:007233135 | Thyroid | ATC | signal transduction by p53 class mediator | 102/6293 | 163/18723 | 3.16e-14 | 1.75e-12 | 102 |
GO:007121427 | Thyroid | ATC | cellular response to abiotic stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:010400427 | Thyroid | ATC | cellular response to environmental stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:007147825 | Thyroid | ATC | cellular response to radiation | 101/6293 | 186/18723 | 4.67e-09 | 1.04e-07 | 101 |
GO:000931426 | Thyroid | ATC | response to radiation | 210/6293 | 456/18723 | 1.69e-08 | 3.39e-07 | 210 |
GO:007233233 | Thyroid | ATC | intrinsic apoptotic signaling pathway by p53 class mediator | 49/6293 | 76/18723 | 3.60e-08 | 6.67e-07 | 49 |
GO:0010212110 | Thyroid | ATC | response to ionizing radiation | 82/6293 | 148/18723 | 3.88e-08 | 7.15e-07 | 82 |
GO:007147927 | Thyroid | ATC | cellular response to ionizing radiation | 46/6293 | 72/18723 | 1.41e-07 | 2.30e-06 | 46 |
GO:004277131 | Thyroid | ATC | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 30/6293 | 43/18723 | 1.36e-06 | 1.71e-05 | 30 |
GO:000863026 | Thyroid | ATC | intrinsic apoptotic signaling pathway in response to DNA damage | 56/6293 | 99/18723 | 2.22e-06 | 2.63e-05 | 56 |
GO:007148022 | Thyroid | ATC | cellular response to gamma radiation | 22/6293 | 31/18723 | 2.35e-05 | 2.06e-04 | 22 |
GO:001033217 | Thyroid | ATC | response to gamma radiation | 34/6293 | 56/18723 | 2.92e-05 | 2.45e-04 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM109 | insertion | Nonsense_Mutation | novel | c.531_532insCAGGAAGGAGAGACAGCCTGTTGGCCATCCCTGTAGAC | p.Ser178GlnfsTer12 | p.S178Qfs*12 | Q9BVC6 | protein_coding | | | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TMEM109 | insertion | Frame_Shift_Ins | novel | c.98_99insGG | p.Gln34AlafsTer22 | p.Q34Afs*22 | Q9BVC6 | protein_coding | | | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
TMEM109 | insertion | Frame_Shift_Ins | novel | c.99_100insAGACAGCCACTGGAGAGTTGGGGCTGGCACAGAA | p.Gln34ArgfsTer30 | p.Q34Rfs*30 | Q9BVC6 | protein_coding | | | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
TMEM109 | insertion | Nonsense_Mutation | novel | c.136_137insGGGTCATCCTATGGCAGAAGGCAGAACCCAGCACATG | p.Lys46ArgfsTer13 | p.K46Rfs*13 | Q9BVC6 | protein_coding | | | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD |
TMEM109 | deletion | Frame_Shift_Del | novel | c.29delN | p.Gly11GlufsTer9 | p.G11Efs*9 | Q9BVC6 | protein_coding | | | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM109 | SNV | Missense_Mutation | | c.690N>T | p.Gln230His | p.Q230H | Q9BVC6 | protein_coding | deleterious(0) | possibly_damaging(0.81) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM109 | SNV | Missense_Mutation | novel | c.553C>T | p.Arg185Trp | p.R185W | Q9BVC6 | protein_coding | deleterious(0) | benign(0.023) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM109 | SNV | Missense_Mutation | | c.298T>C | p.Ser100Pro | p.S100P | Q9BVC6 | protein_coding | tolerated(0.23) | probably_damaging(0.992) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TMEM109 | SNV | Missense_Mutation | novel | c.50C>T | p.Ala17Val | p.A17V | Q9BVC6 | protein_coding | tolerated_low_confidence(0.7) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM109 | SNV | Missense_Mutation | rs753654818 | c.310N>A | p.Ala104Thr | p.A104T | Q9BVC6 | protein_coding | deleterious(0.04) | benign(0.029) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |