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Gene: TFG |
Gene summary for TFG |
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Gene information | Species | Human | Gene symbol | TFG | Gene ID | 10342 |
Gene name | trafficking from ER to golgi regulator | |
Gene Alias | HMSNP | |
Cytomap | 3q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q92734 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10342 | TFG | CA_HPV_1 | Human | Cervix | CC | 5.70e-04 | -1.66e-01 | 0.0264 |
10342 | TFG | CCI_3 | Human | Cervix | CC | 3.61e-08 | 7.88e-01 | 0.516 |
10342 | TFG | Tumor | Human | Cervix | CC | 7.35e-16 | 4.70e-01 | 0.1241 |
10342 | TFG | sample3 | Human | Cervix | CC | 8.23e-28 | 5.45e-01 | 0.1387 |
10342 | TFG | L1 | Human | Cervix | CC | 8.83e-08 | 1.78e-01 | 0.0802 |
10342 | TFG | T3 | Human | Cervix | CC | 4.93e-30 | 5.75e-01 | 0.1389 |
10342 | TFG | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.69e-03 | -3.13e-01 | 0.0155 |
10342 | TFG | HTA11_347_2000001011 | Human | Colorectum | AD | 1.45e-07 | 4.52e-01 | -0.1954 |
10342 | TFG | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.30e-03 | -3.05e-01 | 0.3005 |
10342 | TFG | A002-C-010 | Human | Colorectum | FAP | 2.50e-04 | -2.04e-01 | 0.242 |
10342 | TFG | A015-C-203 | Human | Colorectum | FAP | 4.54e-25 | -5.02e-01 | -0.1294 |
10342 | TFG | A015-C-204 | Human | Colorectum | FAP | 2.06e-08 | -4.35e-01 | -0.0228 |
10342 | TFG | A014-C-040 | Human | Colorectum | FAP | 1.40e-02 | -4.12e-01 | -0.1184 |
10342 | TFG | A002-C-201 | Human | Colorectum | FAP | 8.44e-11 | -3.75e-01 | 0.0324 |
10342 | TFG | A002-C-203 | Human | Colorectum | FAP | 2.66e-05 | -2.25e-01 | 0.2786 |
10342 | TFG | A001-C-119 | Human | Colorectum | FAP | 8.46e-10 | -4.69e-01 | -0.1557 |
10342 | TFG | A001-C-108 | Human | Colorectum | FAP | 6.51e-17 | -3.94e-01 | -0.0272 |
10342 | TFG | A002-C-205 | Human | Colorectum | FAP | 7.65e-19 | -5.25e-01 | -0.1236 |
10342 | TFG | A001-C-104 | Human | Colorectum | FAP | 3.02e-08 | -3.38e-01 | 0.0184 |
10342 | TFG | A015-C-005 | Human | Colorectum | FAP | 7.68e-04 | -3.30e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00481996 | Esophagus | HGIN | vesicle targeting, to, from or within Golgi | 8/2587 | 21/18723 | 5.00e-03 | 4.19e-02 | 8 |
GO:00069017 | Esophagus | HGIN | vesicle coating | 7/2587 | 17/18723 | 5.21e-03 | 4.30e-02 | 7 |
GO:005164810 | Esophagus | HGIN | vesicle localization | 37/2587 | 177/18723 | 6.03e-03 | 4.87e-02 | 37 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0006900111 | Esophagus | ESCC | vesicle budding from membrane | 54/8552 | 61/18723 | 2.66e-12 | 1.07e-10 | 54 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:009011414 | Esophagus | ESCC | COPII-coated vesicle budding | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05216 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa052161 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa052164 | Colorectum | FAP | Thyroid cancer | 12/1404 | 37/8465 | 1.33e-02 | 4.46e-02 | 2.71e-02 | 12 |
hsa052165 | Colorectum | FAP | Thyroid cancer | 12/1404 | 37/8465 | 1.33e-02 | 4.46e-02 | 2.71e-02 | 12 |
hsa0521610 | Endometrium | AEH | Thyroid cancer | 12/1197 | 37/8465 | 3.68e-03 | 2.14e-02 | 1.56e-02 | 12 |
hsa0521615 | Endometrium | AEH | Thyroid cancer | 12/1197 | 37/8465 | 3.68e-03 | 2.14e-02 | 1.56e-02 | 12 |
hsa0521625 | Endometrium | EEC | Thyroid cancer | 13/1237 | 37/8465 | 1.51e-03 | 9.55e-03 | 7.12e-03 | 13 |
hsa0521635 | Endometrium | EEC | Thyroid cancer | 13/1237 | 37/8465 | 1.51e-03 | 9.55e-03 | 7.12e-03 | 13 |
hsa0521620 | Esophagus | HGIN | Thyroid cancer | 13/1383 | 37/8465 | 4.20e-03 | 3.04e-02 | 2.41e-02 | 13 |
hsa05216110 | Esophagus | HGIN | Thyroid cancer | 13/1383 | 37/8465 | 4.20e-03 | 3.04e-02 | 2.41e-02 | 13 |
hsa0521628 | Esophagus | ESCC | Thyroid cancer | 32/4205 | 37/8465 | 2.98e-06 | 1.72e-05 | 8.81e-06 | 32 |
hsa0521638 | Esophagus | ESCC | Thyroid cancer | 32/4205 | 37/8465 | 2.98e-06 | 1.72e-05 | 8.81e-06 | 32 |
hsa052167 | Liver | Cirrhotic | Thyroid cancer | 23/2530 | 37/8465 | 4.63e-05 | 3.28e-04 | 2.02e-04 | 23 |
hsa0521612 | Liver | Cirrhotic | Thyroid cancer | 23/2530 | 37/8465 | 4.63e-05 | 3.28e-04 | 2.02e-04 | 23 |
hsa0521622 | Liver | HCC | Thyroid cancer | 29/4020 | 37/8465 | 1.18e-04 | 5.88e-04 | 3.27e-04 | 29 |
hsa0521632 | Liver | HCC | Thyroid cancer | 29/4020 | 37/8465 | 1.18e-04 | 5.88e-04 | 3.27e-04 | 29 |
hsa0521618 | Oral cavity | OSCC | Thyroid cancer | 27/3704 | 37/8465 | 2.97e-04 | 9.39e-04 | 4.78e-04 | 27 |
hsa0521619 | Oral cavity | OSCC | Thyroid cancer | 27/3704 | 37/8465 | 2.97e-04 | 9.39e-04 | 4.78e-04 | 27 |
hsa0521627 | Oral cavity | LP | Thyroid cancer | 21/2418 | 37/8465 | 2.98e-04 | 1.60e-03 | 1.03e-03 | 21 |
hsa0521637 | Oral cavity | LP | Thyroid cancer | 21/2418 | 37/8465 | 2.98e-04 | 1.60e-03 | 1.03e-03 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFG | SNV | Missense_Mutation | c.455C>T | p.Ser152Phe | p.S152F | Q92734 | protein_coding | tolerated(0.07) | benign(0.1) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
TFG | SNV | Missense_Mutation | novel | c.513A>T | p.Leu171Phe | p.L171F | Q92734 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
TFG | SNV | Missense_Mutation | c.1165N>T | p.Gly389Cys | p.G389C | Q92734 | protein_coding | tolerated_low_confidence(0.08) | benign(0.334) | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR | |
TFG | SNV | Missense_Mutation | novel | c.658C>T | p.Pro220Ser | p.P220S | Q92734 | protein_coding | tolerated(0.08) | benign(0.057) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFG | SNV | Missense_Mutation | c.455N>T | p.Ser152Phe | p.S152F | Q92734 | protein_coding | tolerated(0.07) | benign(0.1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TFG | SNV | Missense_Mutation | rs146078119 | c.1147N>T | p.Arg383Cys | p.R383C | Q92734 | protein_coding | tolerated_low_confidence(0.05) | benign(0.005) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TFG | SNV | Missense_Mutation | novel | c.519N>A | p.Asn173Lys | p.N173K | Q92734 | protein_coding | tolerated(0.06) | probably_damaging(0.979) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFG | SNV | Missense_Mutation | novel | c.519C>A | p.Asn173Lys | p.N173K | Q92734 | protein_coding | tolerated(0.06) | probably_damaging(0.979) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TFG | SNV | Missense_Mutation | rs373719892 | c.1154G>A | p.Arg385His | p.R385H | Q92734 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.987) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TFG | SNV | Missense_Mutation | rs774808090 | c.68N>A | p.Arg23Gln | p.R23Q | Q92734 | protein_coding | deleterious(0) | possibly_damaging(0.552) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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