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Gene: TCP1 |
Gene summary for TCP1 |
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Gene information | Species | Human | Gene symbol | TCP1 | Gene ID | 6950 |
Gene name | t-complex 1 | |
Gene Alias | CCT-alpha | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | E7EQR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6950 | TCP1 | GSM4909277 | Human | Breast | Precancer | 4.84e-06 | 5.52e-01 | 0.0177 |
6950 | TCP1 | GSM4909285 | Human | Breast | IDC | 7.02e-09 | 3.16e-01 | 0.21 |
6950 | TCP1 | GSM4909286 | Human | Breast | IDC | 1.72e-03 | 9.92e-03 | 0.1081 |
6950 | TCP1 | GSM4909293 | Human | Breast | IDC | 2.28e-02 | -1.72e-01 | 0.1581 |
6950 | TCP1 | GSM4909296 | Human | Breast | IDC | 3.13e-19 | -5.37e-01 | 0.1524 |
6950 | TCP1 | GSM4909297 | Human | Breast | IDC | 1.43e-17 | -4.55e-01 | 0.1517 |
6950 | TCP1 | GSM4909298 | Human | Breast | IDC | 6.92e-05 | -2.70e-01 | 0.1551 |
6950 | TCP1 | GSM4909301 | Human | Breast | IDC | 6.07e-11 | -4.10e-01 | 0.1577 |
6950 | TCP1 | GSM4909302 | Human | Breast | IDC | 3.62e-15 | -5.13e-01 | 0.1545 |
6950 | TCP1 | GSM4909304 | Human | Breast | IDC | 4.33e-05 | -3.20e-01 | 0.1636 |
6950 | TCP1 | GSM4909307 | Human | Breast | IDC | 4.02e-09 | -4.13e-01 | 0.1569 |
6950 | TCP1 | GSM4909309 | Human | Breast | IDC | 3.59e-12 | -5.17e-01 | 0.0483 |
6950 | TCP1 | GSM4909311 | Human | Breast | IDC | 3.18e-34 | -5.70e-01 | 0.1534 |
6950 | TCP1 | GSM4909312 | Human | Breast | IDC | 3.93e-09 | -2.61e-01 | 0.1552 |
6950 | TCP1 | GSM4909313 | Human | Breast | IDC | 2.15e-04 | -3.56e-01 | 0.0391 |
6950 | TCP1 | GSM4909315 | Human | Breast | IDC | 5.62e-05 | -3.45e-01 | 0.21 |
6950 | TCP1 | GSM4909319 | Human | Breast | IDC | 8.32e-37 | -6.19e-01 | 0.1563 |
6950 | TCP1 | GSM4909320 | Human | Breast | IDC | 2.06e-10 | -5.51e-01 | 0.1575 |
6950 | TCP1 | GSM4909321 | Human | Breast | IDC | 1.92e-14 | -3.25e-01 | 0.1559 |
6950 | TCP1 | brca1 | Human | Breast | Precancer | 5.45e-03 | 3.08e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:005082124 | Breast | DCIS | protein stabilization | 36/1390 | 191/18723 | 1.82e-07 | 9.14e-06 | 36 |
GO:005170124 | Breast | DCIS | biological process involved in interaction with host | 34/1390 | 203/18723 | 6.30e-06 | 1.78e-04 | 34 |
GO:190495123 | Breast | DCIS | positive regulation of establishment of protein localization | 45/1390 | 319/18723 | 2.36e-05 | 5.52e-04 | 45 |
GO:001083323 | Breast | DCIS | telomere maintenance via telomere lengthening | 16/1390 | 81/18723 | 2.61e-04 | 4.01e-03 | 16 |
GO:190435822 | Breast | DCIS | positive regulation of telomere maintenance via telomere lengthening | 10/1390 | 37/18723 | 2.68e-04 | 4.06e-03 | 10 |
GO:200027822 | Breast | DCIS | regulation of DNA biosynthetic process | 19/1390 | 106/18723 | 2.74e-04 | 4.09e-03 | 19 |
GO:200057322 | Breast | DCIS | positive regulation of DNA biosynthetic process | 14/1390 | 66/18723 | 2.88e-04 | 4.25e-03 | 14 |
GO:199017321 | Breast | DCIS | protein localization to nucleoplasm | 6/1390 | 14/18723 | 2.96e-04 | 4.32e-03 | 6 |
GO:190382924 | Breast | DCIS | positive regulation of cellular protein localization | 37/1390 | 276/18723 | 3.40e-04 | 4.87e-03 | 37 |
GO:007259423 | Breast | DCIS | establishment of protein localization to organelle | 51/1390 | 422/18723 | 3.91e-04 | 5.40e-03 | 51 |
GO:190485121 | Breast | DCIS | positive regulation of establishment of protein localization to telomere | 5/1390 | 10/18723 | 4.11e-04 | 5.55e-03 | 5 |
GO:190435622 | Breast | DCIS | regulation of telomere maintenance via telomere lengthening | 13/1390 | 61/18723 | 4.48e-04 | 5.98e-03 | 13 |
GO:190487421 | Breast | DCIS | positive regulation of telomerase RNA localization to Cajal body | 6/1390 | 15/18723 | 4.62e-04 | 6.12e-03 | 6 |
GO:000700422 | Breast | DCIS | telomere maintenance via telomerase | 14/1390 | 69/18723 | 4.67e-04 | 6.17e-03 | 14 |
GO:003221221 | Breast | DCIS | positive regulation of telomere maintenance via telomerase | 9/1390 | 34/18723 | 6.39e-04 | 7.92e-03 | 9 |
GO:005197322 | Breast | DCIS | positive regulation of telomerase activity | 9/1390 | 34/18723 | 6.39e-04 | 7.92e-03 | 9 |
GO:000072321 | Breast | DCIS | telomere maintenance | 21/1390 | 131/18723 | 6.45e-04 | 7.96e-03 | 21 |
GO:007020321 | Breast | DCIS | regulation of establishment of protein localization to telomere | 5/1390 | 11/18723 | 7.08e-04 | 8.51e-03 | 5 |
GO:190486921 | Breast | DCIS | regulation of protein localization to Cajal body | 5/1390 | 11/18723 | 7.08e-04 | 8.51e-03 | 5 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCP1 | SNV | Missense_Mutation | novel | c.1640N>G | p.Asp547Gly | p.D547G | P17987 | protein_coding | tolerated_low_confidence(0.12) | benign(0.007) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
TCP1 | deletion | Frame_Shift_Del | c.1430delN | p.Asn477ThrfsTer7 | p.N477Tfs*7 | P17987 | protein_coding | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |||
TCP1 | SNV | Missense_Mutation | novel | c.1555N>C | p.Glu519Gln | p.E519Q | P17987 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
TCP1 | SNV | Missense_Mutation | novel | c.396N>G | p.Ile132Met | p.I132M | P17987 | protein_coding | tolerated(0.2) | possibly_damaging(0.706) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TCP1 | SNV | Missense_Mutation | c.1438N>T | p.Arg480Cys | p.R480C | P17987 | protein_coding | deleterious(0.02) | possibly_damaging(0.579) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
TCP1 | SNV | Missense_Mutation | c.10N>T | p.Pro4Ser | p.P4S | P17987 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TCP1 | SNV | Missense_Mutation | novel | c.501N>A | p.Phe167Leu | p.F167L | P17987 | protein_coding | tolerated(0.26) | benign(0.044) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCP1 | SNV | Missense_Mutation | rs760874138 | c.1297N>T | p.Arg433Trp | p.R433W | P17987 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-5255-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TCP1 | SNV | Missense_Mutation | c.1064N>T | p.Arg355Ile | p.R355I | P17987 | protein_coding | deleterious(0.03) | possibly_damaging(0.781) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TCP1 | SNV | Missense_Mutation | novel | c.944N>G | p.Asp315Gly | p.D315G | P17987 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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