Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SORT1

Gene summary for SORT1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SORT1

Gene ID

6272

Gene namesortilin 1
Gene AliasGp95
Cytomap1p13.3
Gene Typeprotein-coding
GO ID

GO:0001503

UniProtAcc

Q99523


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6272SORT1LZE24THumanEsophagusESCC3.38e-061.04e-010.0596
6272SORT1P1T-EHumanEsophagusESCC1.09e-032.92e-010.0875
6272SORT1P2T-EHumanEsophagusESCC3.20e-071.66e-010.1177
6272SORT1P4T-EHumanEsophagusESCC3.98e-132.96e-010.1323
6272SORT1P5T-EHumanEsophagusESCC4.09e-081.70e-010.1327
6272SORT1P8T-EHumanEsophagusESCC1.53e-151.83e-010.0889
6272SORT1P10T-EHumanEsophagusESCC6.79e-111.60e-010.116
6272SORT1P12T-EHumanEsophagusESCC2.00e-275.49e-010.1122
6272SORT1P16T-EHumanEsophagusESCC9.42e-172.06e-010.1153
6272SORT1P17T-EHumanEsophagusESCC9.55e-041.80e-010.1278
6272SORT1P19T-EHumanEsophagusESCC9.77e-033.02e-010.1662
6272SORT1P20T-EHumanEsophagusESCC3.37e-041.41e-010.1124
6272SORT1P21T-EHumanEsophagusESCC1.32e-022.99e-020.1617
6272SORT1P22T-EHumanEsophagusESCC2.21e-04-1.47e-020.1236
6272SORT1P24T-EHumanEsophagusESCC1.15e-063.58e-020.1287
6272SORT1P26T-EHumanEsophagusESCC3.72e-088.00e-020.1276
6272SORT1P27T-EHumanEsophagusESCC4.23e-061.19e-010.1055
6272SORT1P28T-EHumanEsophagusESCC9.05e-068.59e-020.1149
6272SORT1P37T-EHumanEsophagusESCC7.40e-183.00e-010.1371
6272SORT1P39T-EHumanEsophagusESCC1.46e-081.18e-010.0894
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001648213ProstateTumorcytosolic transport54/3246168/187232.01e-063.46e-0554
GO:000862515ProstateTumorextrinsic apoptotic signaling pathway via death domain receptors32/324682/187232.65e-064.44e-0532
GO:003286815ProstateTumorresponse to insulin75/3246264/187234.94e-067.68e-0575
GO:190401912ProstateTumorepithelial cell apoptotic process41/3246121/187237.85e-061.16e-0441
GO:000662313ProstateTumorprotein targeting to vacuole18/324637/187231.17e-051.66e-0418
GO:007266612ProstateTumorestablishment of protein localization to vacuole21/324649/187232.59e-053.18e-0421
GO:005134617ProstateTumornegative regulation of hydrolase activity97/3246379/187232.87e-053.46e-0497
GO:000703414ProstateTumorvacuolar transport48/3246157/187233.18e-053.78e-0448
GO:000689213ProstateTumorpost-Golgi vesicle-mediated transport35/3246104/187234.14e-054.70e-0435
GO:199008914ProstateTumorresponse to nerve growth factor22/324656/187238.33e-058.38e-0422
GO:199009013ProstateTumorcellular response to nerve growth factor stimulus21/324653/187231.04e-041.00e-0321
GO:006146211ProstateTumorprotein localization to lysosome19/324646/187231.14e-041.08e-0319
GO:001619713ProstateTumorendosomal transport62/3246230/187231.65e-041.47e-0362
GO:004269213ProstateTumormuscle cell differentiation93/3246384/187233.45e-042.73e-0393
GO:190403511ProstateTumorregulation of epithelial cell apoptotic process30/324696/187236.03e-044.31e-0330
GO:000704113ProstateTumorlysosomal transport34/3246114/187237.00e-044.92e-0334
GO:000662211ProstateTumorprotein targeting to lysosome11/324623/187237.28e-045.08e-0311
GO:007198512ProstateTumormultivesicular body sorting pathway15/324637/187237.46e-045.14e-0315
GO:004559811ProstateTumorregulation of fat cell differentiation39/3246139/187231.11e-037.12e-0339
GO:005114614ProstateTumorstriated muscle cell differentiation69/3246283/187231.56e-039.54e-0369
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0414222EsophagusESCCLysosome102/4205132/84655.11e-117.13e-103.65e-10102
hsa0472225EsophagusESCCNeurotrophin signaling pathway80/4205119/84657.33e-053.07e-041.57e-0480
hsa0414232EsophagusESCCLysosome102/4205132/84655.11e-117.13e-103.65e-10102
hsa04722111EsophagusESCCNeurotrophin signaling pathway80/4205119/84657.33e-053.07e-041.57e-0480
hsa041424LiverCirrhoticLysosome68/2530132/84651.34e-071.97e-061.21e-0668
hsa049792LiverCirrhoticCholesterol metabolism30/253051/84651.59e-051.39e-048.60e-0530
hsa0414211LiverCirrhoticLysosome68/2530132/84651.34e-071.97e-061.21e-0668
hsa049793LiverCirrhoticCholesterol metabolism30/253051/84651.59e-051.39e-048.60e-0530
hsa041422LiverHCCLysosome100/4020132/84652.32e-114.31e-102.40e-10100
hsa049794LiverHCCCholesterol metabolism41/402051/84651.33e-061.35e-057.49e-0641
hsa0472210LiverHCCNeurotrophin signaling pathway74/4020119/84658.27e-043.26e-031.81e-0374
hsa041423LiverHCCLysosome100/4020132/84652.32e-114.31e-102.40e-10100
hsa049795LiverHCCCholesterol metabolism41/402051/84651.33e-061.35e-057.49e-0641
hsa0472211LiverHCCNeurotrophin signaling pathway74/4020119/84658.27e-043.26e-031.81e-0374
hsa0472223ProstateTumorNeurotrophin signaling pathway39/1791119/84652.01e-038.10e-035.02e-0339
hsa0472233ProstateTumorNeurotrophin signaling pathway39/1791119/84652.01e-038.10e-035.02e-0339
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
GRNSORT1GRN_SORT1GRNBreastDCIS
GRNSORT1GRN_SORT1GRNCervixADJ
GRNSORT1GRN_SORT1GRNCervixCC
GRNSORT1GRN_SORT1GRNCervixPrecancer
GRNSORT1GRN_SORT1GRNCRCAD
GRNSORT1GRN_SORT1GRNCRCADJ
GRNSORT1GRN_SORT1GRNCRCMSI-H
GRNSORT1GRN_SORT1GRNCRCMSS
GRNSORT1GRN_SORT1GRNCRCSER
GRNSORT1GRN_SORT1GRNEndometriumADJ
GRNSORT1GRN_SORT1GRNEndometriumAEH
GRNSORT1GRN_SORT1GRNEndometriumHealthy
GRNSORT1GRN_SORT1GRNEsophagusESCC
GRNSORT1GRN_SORT1GRNGCADJ
GRNSORT1GRN_SORT1GRNHNSCCADJ
GRNSORT1GRN_SORT1GRNHNSCCOSCC
GRNSORT1GRN_SORT1GRNHNSCCPrecancer
GRNSORT1GRN_SORT1GRNLiverHCC
GRNSORT1GRN_SORT1GRNLungAAH
GRNSORT1GRN_SORT1GRNLungADJ
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SORT1SNVMissense_Mutationc.845N>Ap.Gly282Glup.G282EQ99523protein_codingdeleterious(0)probably_damaging(0.954)TCGA-AO-A03R-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SORT1SNVMissense_Mutationnovelc.1799N>Cp.Tyr600Serp.Y600SQ99523protein_codingtolerated(0.12)possibly_damaging(0.857)TCGA-B6-A0RT-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
SORT1SNVMissense_Mutationnovelc.1999C>Tp.Leu667Phep.L667FQ99523protein_codingtolerated(0.39)benign(0.159)TCGA-OL-A5RW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
SORT1insertionNonsense_Mutationnovelc.1279_1280insATGAAATGAGTCAGGGAGCTTCAGTTAGAAAATAAAGTTGAGGp.Thr427AsnfsTer12p.T427Nfs*12Q99523protein_codingTCGA-AN-A041-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SORT1deletionFrame_Shift_Delnovelc.2019delTp.Leu674SerfsTer21p.L674Sfs*21Q99523protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
SORT1SNVMissense_Mutationc.1439C>Tp.Ser480Leup.S480LQ99523protein_codingdeleterious(0)probably_damaging(0.989)TCGA-EK-A2RK-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
SORT1SNVMissense_Mutationnovelc.313T>Gp.Phe105Valp.F105VQ99523protein_codingdeleterious(0)probably_damaging(0.969)TCGA-AA-3949-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
SORT1SNVMissense_Mutationc.1406N>Tp.Ser469Phep.S469FQ99523protein_codingtolerated(0.13)benign(0.144)TCGA-AA-A01R-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapy5-fluorouracilPD
SORT1SNVMissense_Mutationnovelc.2230T>Ap.Phe744Ilep.F744IQ99523protein_codingtolerated(0.22)benign(0.015)TCGA-AA-A02R-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
SORT1SNVMissense_Mutationc.706N>Ap.Glu236Lysp.E236KQ99523protein_codingtolerated(0.69)benign(0)TCGA-AA-A02W-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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