![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SIX1 |
Gene summary for SIX1 |
![]() |
Gene information | Species | Human | Gene symbol | SIX1 | Gene ID | 6495 |
Gene name | SIX homeobox 1 | |
Gene Alias | BOS3 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q15475 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6495 | SIX1 | GSM4909285 | Human | Breast | IDC | 4.96e-49 | 6.69e-01 | 0.21 |
6495 | SIX1 | GSM4909286 | Human | Breast | IDC | 3.85e-08 | 1.72e-01 | 0.1081 |
6495 | SIX1 | GSM4909289 | Human | Breast | IDC | 6.15e-05 | 2.84e-01 | 0.1064 |
6495 | SIX1 | GSM4909290 | Human | Breast | IDC | 5.92e-12 | 2.65e-01 | 0.2096 |
6495 | SIX1 | GSM4909291 | Human | Breast | IDC | 1.38e-09 | 2.62e-01 | 0.1753 |
6495 | SIX1 | GSM4909293 | Human | Breast | IDC | 1.19e-30 | 4.61e-01 | 0.1581 |
6495 | SIX1 | GSM4909294 | Human | Breast | IDC | 1.79e-07 | 1.91e-01 | 0.2022 |
6495 | SIX1 | GSM4909298 | Human | Breast | IDC | 2.52e-23 | 4.03e-01 | 0.1551 |
6495 | SIX1 | GSM4909306 | Human | Breast | IDC | 1.77e-06 | 1.59e-01 | 0.1564 |
6495 | SIX1 | GSM4909312 | Human | Breast | IDC | 8.07e-06 | 2.27e-01 | 0.1552 |
6495 | SIX1 | GSM4909313 | Human | Breast | IDC | 1.84e-02 | 1.44e-01 | 0.0391 |
6495 | SIX1 | GSM4909317 | Human | Breast | IDC | 3.47e-25 | 4.67e-01 | 0.1355 |
6495 | SIX1 | GSM4909318 | Human | Breast | IDC | 8.25e-03 | 3.28e-01 | 0.2031 |
6495 | SIX1 | GSM4909321 | Human | Breast | IDC | 3.32e-03 | 1.66e-01 | 0.1559 |
6495 | SIX1 | M1 | Human | Breast | IDC | 5.28e-11 | 2.38e-01 | 0.1577 |
6495 | SIX1 | NCCBC14 | Human | Breast | DCIS | 2.06e-18 | 5.62e-01 | 0.2021 |
6495 | SIX1 | P2 | Human | Breast | IDC | 1.98e-07 | 2.99e-01 | 0.21 |
6495 | SIX1 | LZE4T | Human | Esophagus | ESCC | 9.56e-12 | 3.86e-01 | 0.0811 |
6495 | SIX1 | LZE5T | Human | Esophagus | ESCC | 1.00e-09 | 6.27e-01 | 0.0514 |
6495 | SIX1 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.46e-01 | 0.0667 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00432007 | Esophagus | ESCC | response to amino acid | 74/8552 | 116/18723 | 6.23e-05 | 4.76e-04 | 74 |
GO:00456007 | Esophagus | ESCC | positive regulation of fat cell differentiation | 46/8552 | 66/18723 | 6.72e-05 | 5.11e-04 | 46 |
GO:000110110 | Esophagus | ESCC | response to acid chemical | 84/8552 | 135/18723 | 7.70e-05 | 5.74e-04 | 84 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:00485386 | Esophagus | ESCC | thymus development | 33/8552 | 45/18723 | 1.54e-04 | 1.02e-03 | 33 |
GO:00712305 | Esophagus | ESCC | cellular response to amino acid stimulus | 48/8552 | 71/18723 | 1.55e-04 | 1.03e-03 | 48 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:004352317 | Esophagus | ESCC | regulation of neuron apoptotic process | 122/8552 | 212/18723 | 3.21e-04 | 1.90e-03 | 122 |
GO:00712296 | Esophagus | ESCC | cellular response to acid chemical | 52/8552 | 80/18723 | 3.79e-04 | 2.20e-03 | 52 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:006056010 | Esophagus | ESCC | developmental growth involved in morphogenesis | 131/8552 | 234/18723 | 9.28e-04 | 4.73e-03 | 131 |
GO:190121516 | Esophagus | ESCC | negative regulation of neuron death | 115/8552 | 208/18723 | 3.24e-03 | 1.34e-02 | 115 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIX1 | SNV | Missense_Mutation | c.731N>T | p.Ser244Leu | p.S244L | Q15475 | protein_coding | tolerated_low_confidence(0.39) | benign(0) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
SIX1 | SNV | Missense_Mutation | novel | c.208N>A | p.Leu70Met | p.L70M | Q15475 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIX1 | SNV | Missense_Mutation | c.775N>A | p.Gly259Ser | p.G259S | Q15475 | protein_coding | tolerated_low_confidence(0.95) | benign(0) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SIX1 | SNV | Missense_Mutation | novel | c.340N>C | p.Lys114Gln | p.K114Q | Q15475 | protein_coding | deleterious(0) | possibly_damaging(0.867) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SIX1 | insertion | In_Frame_Ins | novel | c.10_11insCACAGT | p.Met3_Leu4insProGln | p.M3_L4insPQ | Q15475 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
SIX1 | SNV | Missense_Mutation | c.554A>C | p.Lys185Thr | p.K185T | Q15475 | protein_coding | tolerated(0.08) | probably_damaging(0.954) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIX1 | SNV | Missense_Mutation | c.603N>A | p.Asn201Lys | p.N201K | Q15475 | protein_coding | tolerated(0.81) | benign(0.015) | TCGA-AA-3875-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIX1 | SNV | Missense_Mutation | c.775N>A | p.Gly259Ser | p.G259S | Q15475 | protein_coding | tolerated_low_confidence(0.95) | benign(0) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIX1 | SNV | Missense_Mutation | novel | c.98N>C | p.Phe33Ser | p.F33S | Q15475 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIX1 | SNV | Missense_Mutation | c.181N>A | p.Gly61Ser | p.G61S | Q15475 | protein_coding | deleterious(0) | benign(0.327) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |