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Gene: SIK1 |
Gene summary for SIK1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SIK1 | Gene ID | 150094 |
| Gene name | salt inducible kinase 1 | |
| Gene Alias | DEE30 | |
| Cytomap | 21q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P57059 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 150094 | SIK1 | P5T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.16e-01 | 0.1327 |
| 150094 | SIK1 | P9T-E | Human | Esophagus | ESCC | 1.23e-14 | 3.26e-01 | 0.1131 |
| 150094 | SIK1 | P11T-E | Human | Esophagus | ESCC | 3.66e-11 | 5.38e-01 | 0.1426 |
| 150094 | SIK1 | P12T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.48e-02 | 0.1122 |
| 150094 | SIK1 | P22T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.24e-01 | 0.1236 |
| 150094 | SIK1 | P23T-E | Human | Esophagus | ESCC | 3.88e-04 | 1.49e-01 | 0.108 |
| 150094 | SIK1 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.28e-01 | 0.1055 |
| 150094 | SIK1 | P30T-E | Human | Esophagus | ESCC | 1.44e-32 | 9.69e-01 | 0.137 |
| 150094 | SIK1 | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.08e-01 | 0.1187 |
| 150094 | SIK1 | P37T-E | Human | Esophagus | ESCC | 3.92e-24 | 4.86e-01 | 0.1371 |
| 150094 | SIK1 | P47T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.86e-01 | 0.1067 |
| 150094 | SIK1 | P49T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.14e-01 | 0.1768 |
| 150094 | SIK1 | P57T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.21e-02 | 0.0926 |
| 150094 | SIK1 | P62T-E | Human | Esophagus | ESCC | 2.13e-09 | 1.99e-01 | 0.1302 |
| 150094 | SIK1 | P65T-E | Human | Esophagus | ESCC | 6.43e-06 | 1.45e-01 | 0.0978 |
| 150094 | SIK1 | P76T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.69e-01 | 0.1207 |
| 150094 | SIK1 | P80T-E | Human | Esophagus | ESCC | 3.16e-03 | 1.31e-01 | 0.155 |
| 150094 | SIK1 | P94T-E | Human | Esophagus | ESCC | 6.05e-03 | 2.95e-01 | 0.0879 |
| 150094 | SIK1 | P126T-E | Human | Esophagus | ESCC | 7.86e-04 | 2.76e-01 | 0.1125 |
| 150094 | SIK1 | P127T-E | Human | Esophagus | ESCC | 3.68e-10 | 2.11e-01 | 0.0826 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00350513 | Skin | SCCIS | cardiocyte differentiation | 18/919 | 156/18723 | 6.58e-04 | 9.61e-03 | 18 |
| GO:004275215 | Skin | SCCIS | regulation of circadian rhythm | 15/919 | 121/18723 | 8.61e-04 | 1.14e-02 | 15 |
| GO:000964911 | Skin | SCCIS | entrainment of circadian clock | 7/919 | 34/18723 | 1.13e-03 | 1.36e-02 | 7 |
| GO:0009267111 | Skin | SCCIS | cellular response to starvation | 17/919 | 156/18723 | 1.73e-03 | 1.87e-02 | 17 |
| GO:0031669111 | Skin | SCCIS | cellular response to nutrient levels | 21/919 | 215/18723 | 2.13e-03 | 2.17e-02 | 21 |
| GO:000941612 | Skin | SCCIS | response to light stimulus | 28/919 | 320/18723 | 2.29e-03 | 2.30e-02 | 28 |
| GO:00431531 | Skin | SCCIS | entrainment of circadian clock by photoperiod | 6/919 | 29/18723 | 2.47e-03 | 2.40e-02 | 6 |
| GO:0055007 | Skin | SCCIS | cardiac muscle cell differentiation | 14/919 | 125/18723 | 3.31e-03 | 2.97e-02 | 14 |
| GO:005114616 | Skin | SCCIS | striated muscle cell differentiation | 25/919 | 283/18723 | 3.38e-03 | 3.01e-02 | 25 |
| GO:000202814 | Skin | SCCIS | regulation of sodium ion transport | 11/919 | 90/18723 | 4.51e-03 | 3.78e-02 | 11 |
| GO:00096481 | Skin | SCCIS | photoperiodism | 6/919 | 33/18723 | 4.88e-03 | 3.99e-02 | 6 |
| GO:000734617 | Skin | cSCC | regulation of mitotic cell cycle | 192/4864 | 457/18723 | 3.47e-14 | 2.31e-12 | 192 |
| GO:000762323 | Skin | cSCC | circadian rhythm | 89/4864 | 210/18723 | 1.55e-07 | 3.51e-06 | 89 |
| GO:007149628 | Skin | cSCC | cellular response to external stimulus | 125/4864 | 320/18723 | 1.63e-07 | 3.65e-06 | 125 |
| GO:000931424 | Skin | cSCC | response to radiation | 166/4864 | 456/18723 | 4.37e-07 | 8.41e-06 | 166 |
| GO:003166825 | Skin | cSCC | cellular response to extracellular stimulus | 94/4864 | 246/18723 | 1.52e-05 | 1.87e-04 | 94 |
| GO:004851123 | Skin | cSCC | rhythmic process | 110/4864 | 298/18723 | 1.83e-05 | 2.19e-04 | 110 |
| GO:000926722 | Skin | cSCC | cellular response to starvation | 64/4864 | 156/18723 | 2.79e-05 | 3.12e-04 | 64 |
| GO:0042594110 | Skin | cSCC | response to starvation | 77/4864 | 197/18723 | 3.52e-05 | 3.82e-04 | 77 |
| GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565818 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 178102336 | BOSUTINIB | |
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565729 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 340590212 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 178102305 | DASATINIB |
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