Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RRP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RRP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RRP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RRP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RRP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001607224 | Skin | cSCC | rRNA metabolic process | 158/4864 | 236/18723 | 4.06e-40 | 2.83e-37 | 158 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:001603229 | Skin | cSCC | viral process | 211/4864 | 415/18723 | 7.04e-28 | 2.76e-25 | 211 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:004348429 | Skin | cSCC | regulation of RNA splicing | 97/4864 | 148/18723 | 4.66e-24 | 1.08e-21 | 97 |
GO:004227328 | Skin | cSCC | ribosomal large subunit biogenesis | 57/4864 | 72/18723 | 4.90e-21 | 8.53e-19 | 57 |
GO:000961522 | Skin | cSCC | response to virus | 152/4864 | 367/18723 | 5.88e-11 | 2.75e-09 | 152 |
GO:004440328 | Skin | cSCC | biological process involved in symbiotic interaction | 126/4864 | 290/18723 | 6.39e-11 | 2.97e-09 | 126 |
GO:000047022 | Skin | cSCC | maturation of LSU-rRNA | 22/4864 | 28/18723 | 8.75e-09 | 2.76e-07 | 22 |
GO:001908019 | Skin | cSCC | viral gene expression | 50/4864 | 94/18723 | 1.68e-08 | 5.04e-07 | 50 |
GO:00004604 | Skin | cSCC | maturation of 5.8S rRNA | 25/4864 | 35/18723 | 2.34e-08 | 6.68e-07 | 25 |
GO:005181715 | Skin | cSCC | modulation of process of other organism involved in symbiotic interaction | 38/4864 | 81/18723 | 3.88e-05 | 4.17e-04 | 38 |
GO:005185116 | Skin | cSCC | modulation by host of symbiont process | 29/4864 | 60/18723 | 1.62e-04 | 1.42e-03 | 29 |
GO:005134627 | Skin | cSCC | negative regulation of hydrolase activity | 130/4864 | 379/18723 | 1.74e-04 | 1.49e-03 | 130 |
GO:003582115 | Skin | cSCC | modulation of process of other organism | 43/4864 | 106/18723 | 7.14e-04 | 5.03e-03 | 43 |
GO:005170216 | Skin | cSCC | biological process involved in interaction with symbiont | 39/4864 | 94/18723 | 7.37e-04 | 5.15e-03 | 39 |
GO:001908313 | Skin | cSCC | viral transcription | 23/4864 | 50/18723 | 1.75e-03 | 1.06e-02 | 23 |
GO:009858622 | Skin | cSCC | cellular response to virus | 34/4864 | 84/18723 | 2.56e-03 | 1.45e-02 | 34 |
GO:004392312 | Skin | cSCC | positive regulation by host of viral transcription | 9/4864 | 16/18723 | 9.73e-03 | 4.31e-02 | 9 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRP1 | SNV | Missense_Mutation | novel | c.272N>T | p.Ala91Val | p.A91V | P56182 | protein_coding | deleterious(0.02) | benign(0.255) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RRP1 | SNV | Missense_Mutation | | c.1091N>C | p.Gln364Pro | p.Q364P | P56182 | protein_coding | tolerated(0.28) | benign(0.006) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RRP1 | SNV | Missense_Mutation | | c.353N>G | p.Phe118Cys | p.F118C | P56182 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
RRP1 | SNV | Missense_Mutation | | c.677N>T | p.Pro226Leu | p.P226L | P56182 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RRP1 | SNV | Missense_Mutation | rs376330937 | c.985N>T | p.Arg329Trp | p.R329W | P56182 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
RRP1 | insertion | Nonsense_Mutation | novel | c.1073_1074insCGCGTGGCGGATGGAACTGGCATAGGTTATCG | p.Gln358HisfsTer9 | p.Q358Hfs*9 | P56182 | protein_coding | | | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RRP1 | SNV | Missense_Mutation | | c.601G>T | p.Ala201Ser | p.A201S | P56182 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RRP1 | SNV | Missense_Mutation | novel | c.1305G>C | p.Arg435Ser | p.R435S | P56182 | protein_coding | deleterious_low_confidence(0.03) | benign(0.143) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RRP1 | SNV | Missense_Mutation | rs367993051 | c.382N>A | p.Glu128Lys | p.E128K | P56182 | protein_coding | deleterious(0.01) | possibly_damaging(0.833) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
RRP1 | SNV | Missense_Mutation | novel | c.974N>G | p.Tyr325Cys | p.Y325C | P56182 | protein_coding | tolerated(0.16) | probably_damaging(0.998) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |