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Gene: RPAIN |
Gene summary for RPAIN |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPAIN | Gene ID | 84268 |
Gene name | RPA interacting protein | |
Gene Alias | HRIP | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0B4J1T3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84268 | RPAIN | AEH-subject1 | Human | Endometrium | AEH | 4.89e-06 | -1.96e-01 | -0.3059 |
84268 | RPAIN | AEH-subject2 | Human | Endometrium | AEH | 1.23e-09 | -2.33e-01 | -0.2525 |
84268 | RPAIN | AEH-subject3 | Human | Endometrium | AEH | 7.55e-10 | -2.69e-01 | -0.2576 |
84268 | RPAIN | EEC-subject1 | Human | Endometrium | EEC | 1.76e-08 | -1.96e-01 | -0.2682 |
84268 | RPAIN | EEC-subject2 | Human | Endometrium | EEC | 1.09e-11 | -2.85e-01 | -0.2607 |
84268 | RPAIN | EEC-subject3 | Human | Endometrium | EEC | 1.90e-34 | -3.24e-01 | -0.2525 |
84268 | RPAIN | EEC-subject5 | Human | Endometrium | EEC | 1.34e-04 | -2.05e-01 | -0.249 |
84268 | RPAIN | GSM5276934 | Human | Endometrium | EEC | 5.87e-04 | -2.11e-01 | -0.0913 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.89e-24 | -1.64e-01 | -0.1869 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.00e-21 | -1.58e-01 | -0.1875 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.61e-30 | -1.64e-01 | -0.1883 |
84268 | RPAIN | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 9.62e-28 | -2.13e-01 | -0.1934 |
84268 | RPAIN | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.31e-46 | -1.51e-01 | -0.1917 |
84268 | RPAIN | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.90e-44 | -5.60e-02 | -0.1916 |
84268 | RPAIN | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.31e-05 | 2.03e-02 | -0.1269 |
84268 | RPAIN | LZE3D | Human | Esophagus | HGIN | 4.22e-03 | 4.81e-01 | 0.0668 |
84268 | RPAIN | LZE4T | Human | Esophagus | ESCC | 2.31e-13 | 5.90e-01 | 0.0811 |
84268 | RPAIN | LZE7T | Human | Esophagus | ESCC | 2.61e-17 | 1.62e+00 | 0.0667 |
84268 | RPAIN | LZE8T | Human | Esophagus | ESCC | 6.04e-08 | 2.92e-01 | 0.067 |
84268 | RPAIN | LZE20T | Human | Esophagus | ESCC | 1.19e-04 | 6.73e-02 | 0.0662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005117018 | Thyroid | ATC | import into nucleus | 86/6293 | 159/18723 | 8.02e-08 | 1.40e-06 | 86 |
GO:000660617 | Thyroid | ATC | protein import into nucleus | 83/6293 | 155/18723 | 2.38e-07 | 3.70e-06 | 83 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPAIN | SNV | Missense_Mutation | c.457N>C | p.Val153Leu | p.V153L | protein_coding | tolerated(0.87) | benign(0.001) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
RPAIN | SNV | Missense_Mutation | rs572268596 | c.637N>A | p.Val213Ile | p.V213I | protein_coding | tolerated_low_confidence(0.39) | benign(0.003) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPAIN | SNV | Missense_Mutation | c.5C>T | p.Ala2Val | p.A2V | protein_coding | deleterious(0) | possibly_damaging(0.454) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
RPAIN | SNV | Missense_Mutation | rs760113626 | c.131N>G | p.Tyr44Cys | p.Y44C | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
RPAIN | SNV | Missense_Mutation | c.101N>T | p.Arg34Ile | p.R34I | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPAIN | SNV | Missense_Mutation | novel | c.562N>A | p.Pro188Thr | p.P188T | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPAIN | SNV | Missense_Mutation | novel | c.481N>T | p.Pro161Ser | p.P161S | protein_coding | tolerated(0.58) | benign(0.019) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
RPAIN | SNV | Missense_Mutation | novel | c.464A>G | p.Gln155Arg | p.Q155R | protein_coding | tolerated(0.15) | possibly_damaging(0.463) | TCGA-BG-A0MK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RPAIN | SNV | Missense_Mutation | c.239A>G | p.Glu80Gly | p.E80G | protein_coding | deleterious(0.04) | possibly_damaging(0.461) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPAIN | SNV | Missense_Mutation | novel | c.352N>C | p.Phe118Leu | p.F118L | protein_coding | deleterious(0) | benign(0.203) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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