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Gene: ROR2 |
Gene summary for ROR2 |
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Gene information | Species | Human | Gene symbol | ROR2 | Gene ID | 4920 |
Gene name | receptor tyrosine kinase like orphan receptor 2 | |
Gene Alias | BDB | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q01974 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4920 | ROR2 | AEH-subject1 | Human | Endometrium | AEH | 3.80e-11 | 4.01e-01 | -0.3059 |
4920 | ROR2 | AEH-subject2 | Human | Endometrium | AEH | 4.70e-04 | 2.31e-01 | -0.2525 |
4920 | ROR2 | AEH-subject3 | Human | Endometrium | AEH | 7.15e-07 | 2.75e-01 | -0.2576 |
4920 | ROR2 | AEH-subject4 | Human | Endometrium | AEH | 1.30e-05 | 3.23e-01 | -0.2657 |
4920 | ROR2 | AEH-subject5 | Human | Endometrium | AEH | 7.97e-05 | 3.26e-01 | -0.2953 |
4920 | ROR2 | EEC-subject1 | Human | Endometrium | EEC | 1.18e-07 | 3.47e-01 | -0.2682 |
4920 | ROR2 | EEC-subject2 | Human | Endometrium | EEC | 1.65e-06 | 3.48e-01 | -0.2607 |
4920 | ROR2 | EEC-subject3 | Human | Endometrium | EEC | 4.77e-05 | -3.31e-02 | -0.2525 |
4920 | ROR2 | GSM5276934 | Human | Endometrium | EEC | 7.71e-03 | -8.13e-02 | -0.0913 |
4920 | ROR2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.21e-09 | -2.76e-03 | -0.1869 |
4920 | ROR2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 5.80e-10 | -4.72e-02 | -0.1875 |
4920 | ROR2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.90e-09 | 4.04e-02 | -0.1883 |
4920 | ROR2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.08e-06 | -4.28e-02 | -0.1934 |
4920 | ROR2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.35e-09 | -1.40e-01 | -0.1917 |
4920 | ROR2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.18e-09 | -8.35e-02 | -0.1916 |
4920 | ROR2 | P2T-E | Human | Esophagus | ESCC | 1.27e-21 | 4.15e-01 | 0.1177 |
4920 | ROR2 | P9T-E | Human | Esophagus | ESCC | 2.04e-08 | 2.09e-01 | 0.1131 |
4920 | ROR2 | P10T-E | Human | Esophagus | ESCC | 1.37e-05 | 6.93e-02 | 0.116 |
4920 | ROR2 | P12T-E | Human | Esophagus | ESCC | 1.17e-06 | 1.20e-01 | 0.1122 |
4920 | ROR2 | P16T-E | Human | Esophagus | ESCC | 2.84e-12 | 2.89e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00719029 | Esophagus | ESCC | positive regulation of protein serine/threonine kinase activity | 124/8552 | 200/18723 | 2.27e-06 | 2.61e-05 | 124 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:00017387 | Esophagus | ESCC | morphogenesis of a polarized epithelium | 63/8552 | 94/18723 | 2.34e-05 | 2.00e-04 | 63 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:00072549 | Esophagus | ESCC | JNK cascade | 102/8552 | 167/18723 | 4.22e-05 | 3.39e-04 | 102 |
GO:009026316 | Esophagus | ESCC | positive regulation of canonical Wnt signaling pathway | 69/8552 | 106/18723 | 4.22e-05 | 3.39e-04 | 69 |
GO:003017716 | Esophagus | ESCC | positive regulation of Wnt signaling pathway | 87/8552 | 140/18723 | 6.18e-05 | 4.73e-04 | 87 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:19021076 | Esophagus | ESCC | positive regulation of leukocyte differentiation | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:19037086 | Esophagus | ESCC | positive regulation of hemopoiesis | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:00600714 | Esophagus | ESCC | Wnt signaling pathway, planar cell polarity pathway | 36/8552 | 52/18723 | 5.05e-04 | 2.79e-03 | 36 |
GO:004563918 | Esophagus | ESCC | positive regulation of myeloid cell differentiation | 64/8552 | 103/18723 | 5.54e-04 | 3.03e-03 | 64 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROR2 | SNV | Missense_Mutation | rs746196217 | c.356N>A | p.Arg119Gln | p.R119Q | Q01974 | protein_coding | deleterious(0) | benign(0.028) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ROR2 | SNV | Missense_Mutation | novel | c.2185T>C | p.Trp729Arg | p.W729R | Q01974 | protein_coding | deleterious(0.02) | benign(0.132) | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROR2 | SNV | Missense_Mutation | novel | c.1333N>G | p.Met445Val | p.M445V | Q01974 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ROR2 | SNV | Missense_Mutation | c.671N>T | p.Ser224Leu | p.S224L | Q01974 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ROR2 | SNV | Missense_Mutation | rs767474960 | c.1448N>A | p.Arg483Gln | p.R483Q | Q01974 | protein_coding | tolerated(0.43) | benign(0.248) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROR2 | SNV | Missense_Mutation | rs373544528 | c.1553G>A | p.Arg518Gln | p.R518Q | Q01974 | protein_coding | tolerated(0.58) | possibly_damaging(0.697) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ROR2 | SNV | Missense_Mutation | novel | c.2468N>C | p.Gly823Ala | p.G823A | Q01974 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.996) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
ROR2 | SNV | Missense_Mutation | c.1518C>G | p.Ile506Met | p.I506M | Q01974 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ROR2 | SNV | Missense_Mutation | novel | c.1479C>A | p.Phe493Leu | p.F493L | Q01974 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-OL-A5RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ROR2 | insertion | Nonsense_Mutation | novel | c.1139_1140insACATGGTGAAACCCCATAAAAATACAAAAATTAGCCAGGTGCGGT | p.Gln380_Asn381insHisGlyGluThrProTerLysTyrLysAsnTerProGlyAlaVal | p.Q380_N381insHGETP*KYKN*PGAV | Q01974 | protein_coding | TCGA-A8-A082-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4920 | ROR2 | KINASE, TYROSINE KINASE, DRUGGABLE GENOME, CELL SURFACE, ENZYME | CCT301-59 (targeting ROR2) | |||
4920 | ROR2 | KINASE, TYROSINE KINASE, DRUGGABLE GENOME, CELL SURFACE, ENZYME | CCT301-38 (targeting ROR2) |
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