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Gene: RND3 |
Gene summary for RND3 |
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Gene information | Species | Human | Gene symbol | RND3 | Gene ID | 390 |
Gene name | Rho family GTPase 3 | |
Gene Alias | ARHE | |
Cytomap | 2q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B2R838 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
390 | RND3 | GSM4909280 | Human | Breast | Precancer | 7.64e-05 | 6.39e-01 | 0.0305 |
390 | RND3 | GSM4909286 | Human | Breast | IDC | 3.79e-22 | -5.88e-01 | 0.1081 |
390 | RND3 | GSM4909290 | Human | Breast | IDC | 3.64e-02 | -3.64e-01 | 0.2096 |
390 | RND3 | GSM4909291 | Human | Breast | IDC | 4.43e-13 | -5.74e-01 | 0.1753 |
390 | RND3 | GSM4909293 | Human | Breast | IDC | 2.48e-05 | -3.63e-01 | 0.1581 |
390 | RND3 | GSM4909294 | Human | Breast | IDC | 5.25e-05 | -4.58e-01 | 0.2022 |
390 | RND3 | GSM4909296 | Human | Breast | IDC | 4.98e-13 | -5.35e-01 | 0.1524 |
390 | RND3 | GSM4909297 | Human | Breast | IDC | 3.19e-09 | -3.99e-01 | 0.1517 |
390 | RND3 | GSM4909298 | Human | Breast | IDC | 1.05e-03 | -3.83e-01 | 0.1551 |
390 | RND3 | GSM4909301 | Human | Breast | IDC | 3.34e-16 | -5.68e-01 | 0.1577 |
390 | RND3 | GSM4909302 | Human | Breast | IDC | 8.57e-14 | -4.78e-01 | 0.1545 |
390 | RND3 | GSM4909306 | Human | Breast | IDC | 8.78e-11 | -5.10e-01 | 0.1564 |
390 | RND3 | GSM4909307 | Human | Breast | IDC | 4.97e-09 | -4.88e-01 | 0.1569 |
390 | RND3 | GSM4909308 | Human | Breast | IDC | 8.63e-15 | -5.38e-01 | 0.158 |
390 | RND3 | GSM4909309 | Human | Breast | IDC | 2.90e-04 | -3.72e-01 | 0.0483 |
390 | RND3 | GSM4909311 | Human | Breast | IDC | 2.77e-21 | -5.50e-01 | 0.1534 |
390 | RND3 | GSM4909312 | Human | Breast | IDC | 6.98e-17 | -5.49e-01 | 0.1552 |
390 | RND3 | GSM4909319 | Human | Breast | IDC | 1.12e-24 | -6.00e-01 | 0.1563 |
390 | RND3 | GSM4909320 | Human | Breast | IDC | 1.32e-08 | -5.66e-01 | 0.1575 |
390 | RND3 | GSM4909321 | Human | Breast | IDC | 4.38e-19 | -5.63e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260427 | Skin | cSCC | regulation of cell morphogenesis | 114/4864 | 309/18723 | 1.34e-05 | 1.68e-04 | 114 |
GO:003295629 | Skin | cSCC | regulation of actin cytoskeleton organization | 127/4864 | 358/18723 | 3.83e-05 | 4.13e-04 | 127 |
GO:003086519 | Skin | cSCC | cortical cytoskeleton organization | 29/4864 | 61/18723 | 2.33e-04 | 1.91e-03 | 29 |
GO:000836025 | Skin | cSCC | regulation of cell shape | 57/4864 | 154/18723 | 1.61e-03 | 9.90e-03 | 57 |
GO:003297030 | Thyroid | HT | regulation of actin filament-based process | 49/1272 | 397/18723 | 3.65e-05 | 7.57e-04 | 49 |
GO:002260428 | Thyroid | HT | regulation of cell morphogenesis | 40/1272 | 309/18723 | 6.49e-05 | 1.19e-03 | 40 |
GO:003295630 | Thyroid | HT | regulation of actin cytoskeleton organization | 43/1272 | 358/18723 | 1.97e-04 | 2.87e-03 | 43 |
GO:000701530 | Thyroid | HT | actin filament organization | 50/1272 | 442/18723 | 2.71e-04 | 3.73e-03 | 50 |
GO:003086520 | Thyroid | HT | cortical cytoskeleton organization | 12/1272 | 61/18723 | 7.13e-04 | 8.03e-03 | 12 |
GO:000716328 | Thyroid | HT | establishment or maintenance of cell polarity | 28/1272 | 218/18723 | 8.66e-04 | 9.20e-03 | 28 |
GO:000836020 | Thyroid | HT | regulation of cell shape | 21/1272 | 154/18723 | 1.74e-03 | 1.57e-02 | 21 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
GO:0032956113 | Thyroid | PTC | regulation of actin cytoskeleton organization | 182/5968 | 358/18723 | 4.64e-14 | 2.79e-12 | 182 |
GO:0032970113 | Thyroid | PTC | regulation of actin filament-based process | 197/5968 | 397/18723 | 8.91e-14 | 4.89e-12 | 197 |
GO:0007163111 | Thyroid | PTC | establishment or maintenance of cell polarity | 115/5968 | 218/18723 | 1.15e-10 | 3.90e-09 | 115 |
GO:0008360111 | Thyroid | PTC | regulation of cell shape | 86/5968 | 154/18723 | 6.22e-10 | 1.95e-08 | 86 |
GO:0030865110 | Thyroid | PTC | cortical cytoskeleton organization | 38/5968 | 61/18723 | 9.77e-07 | 1.46e-05 | 38 |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:0032970210 | Thyroid | ATC | regulation of actin filament-based process | 208/6293 | 397/18723 | 5.82e-15 | 3.80e-13 | 208 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RND3 | SNV | Missense_Mutation | rs747141041 | c.284N>T | p.Ser95Leu | p.S95L | P61587 | protein_coding | deleterious(0.04) | possibly_damaging(0.873) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RND3 | SNV | Missense_Mutation | rs536121901 | c.526N>A | p.Glu176Lys | p.E176K | P61587 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RND3 | SNV | Missense_Mutation | c.268C>A | p.Leu90Ile | p.L90I | P61587 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RND3 | SNV | Missense_Mutation | c.478N>C | p.Asp160His | p.D160H | P61587 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
RND3 | SNV | Missense_Mutation | rs747141041 | c.284C>T | p.Ser95Leu | p.S95L | P61587 | protein_coding | deleterious(0.04) | possibly_damaging(0.873) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
RND3 | SNV | Missense_Mutation | c.242N>A | p.Ser81Tyr | p.S81Y | P61587 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RND3 | SNV | Missense_Mutation | c.290N>T | p.Ala97Val | p.A97V | P61587 | protein_coding | tolerated(0.16) | probably_damaging(0.983) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RND3 | SNV | Missense_Mutation | novel | c.675N>T | p.Glu225Asp | p.E225D | P61587 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RND3 | SNV | Missense_Mutation | novel | c.361N>G | p.Ile121Val | p.I121V | P61587 | protein_coding | tolerated(0.53) | benign(0.067) | TCGA-AJ-A23N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
RND3 | SNV | Missense_Mutation | novel | c.230N>G | p.Asp77Gly | p.D77G | P61587 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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