GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003001025 | Skin | cSCC | establishment of cell polarity | 65/4864 | 143/18723 | 3.60e-07 | 7.18e-06 | 65 |
GO:004545420 | Skin | cSCC | cell redox homeostasis | 19/4864 | 35/18723 | 3.37e-04 | 2.67e-03 | 19 |
GO:005067324 | Skin | cSCC | epithelial cell proliferation | 144/4864 | 437/18723 | 6.07e-04 | 4.38e-03 | 144 |
GO:001063125 | Skin | cSCC | epithelial cell migration | 115/4864 | 357/18723 | 4.64e-03 | 2.37e-02 | 115 |
GO:009013225 | Skin | cSCC | epithelium migration | 115/4864 | 360/18723 | 6.20e-03 | 3.04e-02 | 115 |
GO:009013025 | Skin | cSCC | tissue migration | 115/4864 | 365/18723 | 9.81e-03 | 4.33e-02 | 115 |
GO:000166727 | Skin | cSCC | ameboidal-type cell migration | 146/4864 | 475/18723 | 1.05e-02 | 4.58e-02 | 146 |
GO:0007163111 | Thyroid | PTC | establishment or maintenance of cell polarity | 115/5968 | 218/18723 | 1.15e-10 | 3.90e-09 | 115 |
GO:003001020 | Thyroid | PTC | establishment of cell polarity | 74/5968 | 143/18723 | 6.05e-07 | 9.63e-06 | 74 |
GO:0001667112 | Thyroid | PTC | ameboidal-type cell migration | 198/5968 | 475/18723 | 3.36e-06 | 4.34e-05 | 198 |
GO:0045454110 | Thyroid | PTC | cell redox homeostasis | 23/5968 | 35/18723 | 4.02e-05 | 3.68e-04 | 23 |
GO:0010631111 | Thyroid | PTC | epithelial cell migration | 149/5968 | 357/18723 | 4.83e-05 | 4.33e-04 | 149 |
GO:0090132111 | Thyroid | PTC | epithelium migration | 149/5968 | 360/18723 | 7.89e-05 | 6.74e-04 | 149 |
GO:0090130111 | Thyroid | PTC | tissue migration | 150/5968 | 365/18723 | 1.13e-04 | 9.01e-04 | 150 |
GO:0010632111 | Thyroid | PTC | regulation of epithelial cell migration | 123/5968 | 292/18723 | 1.33e-04 | 1.05e-03 | 123 |
GO:004354219 | Thyroid | PTC | endothelial cell migration | 112/5968 | 279/18723 | 2.03e-03 | 1.09e-02 | 112 |
GO:190401913 | Thyroid | PTC | epithelial cell apoptotic process | 52/5968 | 121/18723 | 6.56e-03 | 2.86e-02 | 52 |
GO:200011416 | Thyroid | PTC | regulation of establishment of cell polarity | 13/5968 | 22/18723 | 7.65e-03 | 3.25e-02 | 13 |
GO:001059416 | Thyroid | PTC | regulation of endothelial cell migration | 91/5968 | 232/18723 | 1.03e-02 | 4.18e-02 | 91 |
GO:003287810 | Thyroid | PTC | regulation of establishment or maintenance of cell polarity | 14/5968 | 25/18723 | 1.07e-02 | 4.30e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIT1 | SNV | Missense_Mutation | novel | c.661N>G | p.Trp221Gly | p.W221G | Q92963 | protein_coding | tolerated(0.06) | probably_damaging(0.968) | TCGA-E2-A14N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
RIT1 | deletion | Frame_Shift_Del | | c.305_314delNNNNNNNNNN | p.Met102SerfsTer3 | p.M102Sfs*3 | Q92963 | protein_coding | | | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
RIT1 | insertion | Frame_Shift_Ins | novel | c.260_261insGGATCTCACTATGTTGCCCAGGCTGATCT | p.Asn87LysfsTer31 | p.N87Kfs*31 | Q92963 | protein_coding | | | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RIT1 | SNV | Missense_Mutation | rs483352822 | c.321N>A | p.Met107Ile | p.M107I | Q92963 | protein_coding | tolerated(0.07) | probably_damaging(0.972) | TCGA-C5-A1ML-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RIT1 | SNV | Missense_Mutation | | c.153N>C | p.Lys51Asn | p.K51N | Q92963 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RIT1 | SNV | Missense_Mutation | rs777167776 | c.262N>G | p.Leu88Val | p.L88V | Q92963 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RIT1 | SNV | Missense_Mutation | | c.565N>A | p.Asp189Asn | p.D189N | Q92963 | protein_coding | tolerated(0.1) | probably_damaging(0.999) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
RIT1 | SNV | Missense_Mutation | novel | c.230T>G | p.Ile77Ser | p.I77S | Q92963 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIT1 | SNV | Missense_Mutation | novel | c.697G>T | p.Asp233Tyr | p.D233Y | Q92963 | protein_coding | deleterious_low_confidence(0) | benign(0.367) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIT1 | SNV | Missense_Mutation | | c.554N>A | p.Arg185His | p.R185H | Q92963 | protein_coding | deleterious(0.01) | benign(0.15) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |