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Gene: RAD51B |
Gene summary for RAD51B |
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Gene information | Species | Human | Gene symbol | RAD51B | Gene ID | 5890 |
Gene name | RAD51 paralog B | |
Gene Alias | R51H2 | |
Cytomap | 14q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O15315 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5890 | RAD51B | CCI_1 | Human | Cervix | CC | 1.18e-27 | 1.84e+00 | 0.528 |
5890 | RAD51B | CCI_2 | Human | Cervix | CC | 5.52e-08 | 6.87e-01 | 0.5249 |
5890 | RAD51B | CCI_3 | Human | Cervix | CC | 2.72e-27 | 1.38e+00 | 0.516 |
5890 | RAD51B | CCII_1 | Human | Cervix | CC | 2.11e-04 | 3.30e-01 | 0.3249 |
5890 | RAD51B | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.60e-03 | -1.95e-01 | 0.0216 |
5890 | RAD51B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.89e-02 | 4.98e-01 | -0.0811 |
5890 | RAD51B | HTA11_78_2000001011 | Human | Colorectum | AD | 2.34e-03 | 5.63e-01 | -0.1088 |
5890 | RAD51B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.40e-04 | 6.09e-01 | -0.059 |
5890 | RAD51B | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.48e-03 | -6.27e-01 | 0.0171 |
5890 | RAD51B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.80e-26 | 1.51e+00 | 0.281 |
5890 | RAD51B | A015-C-203 | Human | Colorectum | FAP | 2.85e-25 | -4.88e-01 | -0.1294 |
5890 | RAD51B | A015-C-204 | Human | Colorectum | FAP | 2.43e-04 | -3.61e-01 | -0.0228 |
5890 | RAD51B | A014-C-040 | Human | Colorectum | FAP | 4.96e-03 | -3.30e-01 | -0.1184 |
5890 | RAD51B | A002-C-201 | Human | Colorectum | FAP | 2.26e-08 | -3.80e-01 | 0.0324 |
5890 | RAD51B | A001-C-119 | Human | Colorectum | FAP | 4.51e-10 | -6.62e-01 | -0.1557 |
5890 | RAD51B | A001-C-108 | Human | Colorectum | FAP | 2.26e-11 | -3.19e-01 | -0.0272 |
5890 | RAD51B | A002-C-205 | Human | Colorectum | FAP | 5.45e-24 | -5.90e-01 | -0.1236 |
5890 | RAD51B | A015-C-005 | Human | Colorectum | FAP | 3.03e-03 | -3.63e-01 | -0.0336 |
5890 | RAD51B | A015-C-006 | Human | Colorectum | FAP | 1.18e-12 | -4.76e-01 | -0.0994 |
5890 | RAD51B | A015-C-106 | Human | Colorectum | FAP | 4.17e-06 | -1.67e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190198913 | Skin | cSCC | positive regulation of cell cycle phase transition | 49/4864 | 115/18723 | 7.55e-05 | 7.24e-04 | 49 |
GO:00063025 | Skin | cSCC | double-strand break repair | 89/4864 | 251/18723 | 5.23e-04 | 3.92e-03 | 89 |
GO:00103892 | Skin | cSCC | regulation of G2/M transition of mitotic cell cycle | 37/4864 | 94/18723 | 3.02e-03 | 1.67e-02 | 37 |
GO:19027492 | Skin | cSCC | regulation of cell cycle G2/M phase transition | 38/4864 | 102/18723 | 7.85e-03 | 3.65e-02 | 38 |
GO:00109713 | Skin | cSCC | positive regulation of G2/M transition of mitotic cell cycle | 13/4864 | 27/18723 | 1.09e-02 | 4.74e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAD51B | SNV | Missense_Mutation | c.751N>G | p.Ile251Val | p.I251V | protein_coding | tolerated(0.05) | benign(0.207) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RAD51B | SNV | Missense_Mutation | c.189N>T | p.Lys63Asn | p.K63N | protein_coding | tolerated(0.11) | benign(0.422) | TCGA-EW-A1IX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | femara | SD | ||
RAD51B | deletion | Frame_Shift_Del | novel | c.1197_1200delAACT | p.Thr400SerfsTer29 | p.T400Sfs*29 | protein_coding | TCGA-DG-A2KJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |||
RAD51B | SNV | Missense_Mutation | c.982G>T | p.Ala328Ser | p.A328S | protein_coding | tolerated(0.45) | possibly_damaging(0.451) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
RAD51B | SNV | Missense_Mutation | novel | c.120G>T | p.Lys40Asn | p.K40N | protein_coding | deleterious(0.03) | benign(0.316) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
RAD51B | SNV | Missense_Mutation | c.111N>T | p.Glu37Asp | p.E37D | protein_coding | tolerated(0.17) | benign(0.263) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
RAD51B | SNV | Missense_Mutation | novel | c.653A>C | p.Lys218Thr | p.K218T | protein_coding | tolerated(0.11) | benign(0.285) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAD51B | SNV | Missense_Mutation | novel | c.521N>T | p.Ser174Ile | p.S174I | protein_coding | deleterious(0.01) | benign(0.029) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
RAD51B | SNV | Missense_Mutation | novel | c.578A>C | p.Glu193Ala | p.E193A | protein_coding | deleterious(0.02) | benign(0.238) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
RAD51B | SNV | Missense_Mutation | novel | c.398N>A | p.Gly133Glu | p.G133E | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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