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Gene: PTPRN |
Gene summary for PTPRN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PTPRN | Gene ID | 5798 |
| Gene name | protein tyrosine phosphatase receptor type N | |
| Gene Alias | IA-2 | |
| Cytomap | 2q35 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q16849 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5798 | PTPRN | HTA12-15-2 | Human | Pancreas | PDAC | 3.53e-08 | 6.77e-01 | 0.2315 |
| 5798 | PTPRN | HTA12-23-1 | Human | Pancreas | PDAC | 2.64e-02 | 5.20e-01 | 0.3405 |
| 5798 | PTPRN | HTA12-26-1 | Human | Pancreas | PDAC | 2.34e-03 | 4.31e-01 | 0.3728 |
| 5798 | PTPRN | HTA12-29-1 | Human | Pancreas | PDAC | 3.39e-11 | 3.82e-01 | 0.3722 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00163114 | Colorectum | CRC | dephosphorylation | 79/2078 | 417/18723 | 1.27e-06 | 7.21e-05 | 79 |
| GO:00064705 | Colorectum | CRC | protein dephosphorylation | 57/2078 | 281/18723 | 4.49e-06 | 1.87e-04 | 57 |
| GO:00097435 | Colorectum | CRC | response to carbohydrate | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
| GO:00335004 | Colorectum | CRC | carbohydrate homeostasis | 49/2078 | 259/18723 | 1.29e-04 | 2.46e-03 | 49 |
| GO:00425934 | Colorectum | CRC | glucose homeostasis | 48/2078 | 258/18723 | 2.27e-04 | 3.78e-03 | 48 |
| GO:00016784 | Colorectum | CRC | cellular glucose homeostasis | 34/2078 | 172/18723 | 5.80e-04 | 7.89e-03 | 34 |
| GO:00342845 | Colorectum | CRC | response to monosaccharide | 41/2078 | 225/18723 | 9.57e-04 | 1.16e-02 | 41 |
| GO:00093064 | Colorectum | CRC | protein secretion | 59/2078 | 359/18723 | 1.32e-03 | 1.48e-02 | 59 |
| GO:00355924 | Colorectum | CRC | establishment of protein localization to extracellular region | 59/2078 | 360/18723 | 1.41e-03 | 1.54e-02 | 59 |
| GO:00097465 | Colorectum | CRC | response to hexose | 39/2078 | 219/18723 | 1.94e-03 | 1.96e-02 | 39 |
| GO:00230611 | Colorectum | CRC | signal release | 72/2078 | 463/18723 | 1.95e-03 | 1.96e-02 | 72 |
| GO:00716924 | Colorectum | CRC | protein localization to extracellular region | 59/2078 | 368/18723 | 2.37e-03 | 2.27e-02 | 59 |
| GO:00097495 | Colorectum | CRC | response to glucose | 37/2078 | 212/18723 | 3.54e-03 | 3.00e-02 | 37 |
| GO:00713224 | Colorectum | CRC | cellular response to carbohydrate stimulus | 30/2078 | 163/18723 | 3.69e-03 | 3.12e-02 | 30 |
| GO:00300734 | Colorectum | CRC | insulin secretion | 34/2078 | 195/18723 | 5.10e-03 | 3.91e-02 | 34 |
| GO:00158334 | Colorectum | CRC | peptide transport | 43/2078 | 264/18723 | 6.47e-03 | 4.68e-02 | 43 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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