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Gene: PTGIS |
Gene summary for PTGIS |
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Gene information | Species | Human | Gene symbol | PTGIS | Gene ID | 5740 |
Gene name | prostaglandin I2 synthase | |
Gene Alias | CYP8 | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0001516 | UniProtAcc | Q16647 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5740 | PTGIS | P2T-E | Human | Esophagus | ESCC | 4.00e-26 | 5.06e-01 | 0.1177 |
5740 | PTGIS | P16T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.71e-01 | 0.1153 |
5740 | PTGIS | P56T-E | Human | Esophagus | ESCC | 2.17e-07 | 7.54e-01 | 0.1613 |
5740 | PTGIS | P76T-E | Human | Esophagus | ESCC | 2.54e-03 | 1.69e-01 | 0.1207 |
5740 | PTGIS | P79T-E | Human | Esophagus | ESCC | 2.52e-03 | 1.00e-01 | 0.1154 |
5740 | PTGIS | HCC1_Meng | Human | Liver | HCC | 1.25e-03 | -9.90e-03 | 0.0246 |
5740 | PTGIS | HCC2_Meng | Human | Liver | HCC | 7.89e-23 | 2.14e-01 | 0.0107 |
5740 | PTGIS | cirrhotic3 | Human | Liver | Cirrhotic | 5.13e-20 | 4.48e-01 | 0.0215 |
5740 | PTGIS | HCC1 | Human | Liver | HCC | 8.27e-05 | 8.80e-01 | 0.5336 |
5740 | PTGIS | HCC2 | Human | Liver | HCC | 4.15e-09 | 7.27e-01 | 0.5341 |
5740 | PTGIS | HCC5 | Human | Liver | HCC | 4.34e-05 | 4.93e-01 | 0.4932 |
5740 | PTGIS | ATC13 | Human | Thyroid | ATC | 1.17e-31 | 8.93e-01 | 0.34 |
5740 | PTGIS | ATC2 | Human | Thyroid | ATC | 9.94e-09 | 1.17e+00 | 0.34 |
5740 | PTGIS | ATC5 | Human | Thyroid | ATC | 1.21e-24 | 9.15e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:008016431 | Thyroid | ATC | regulation of nitric oxide metabolic process | 32/6293 | 64/18723 | 4.85e-03 | 1.99e-02 | 32 |
GO:004542823 | Thyroid | ATC | regulation of nitric oxide biosynthetic process | 31/6293 | 62/18723 | 5.52e-03 | 2.24e-02 | 31 |
GO:007055513 | Thyroid | ATC | response to interleukin-1 | 63/6293 | 143/18723 | 5.82e-03 | 2.35e-02 | 63 |
GO:00434333 | Thyroid | ATC | negative regulation of DNA-binding transcription factor activity | 79/6293 | 185/18723 | 5.96e-03 | 2.40e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGIS | SNV | Missense_Mutation | rs56195291 | c.1135C>T | p.Arg379Cys | p.R379C | Q16647 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
PTGIS | SNV | Missense_Mutation | c.1424N>C | p.Glu475Ala | p.E475A | Q16647 | protein_coding | tolerated(0.65) | benign(0.015) | TCGA-A7-A26J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PTGIS | SNV | Missense_Mutation | c.879C>G | p.Phe293Leu | p.F293L | Q16647 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PTGIS | SNV | Missense_Mutation | novel | c.1416N>T | p.Glu472Asp | p.E472D | Q16647 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGIS | SNV | Missense_Mutation | rs199740067 | c.283N>A | p.Asp95Asn | p.D95N | Q16647 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGIS | SNV | Missense_Mutation | rs767832954 | c.481N>A | p.Glu161Lys | p.E161K | Q16647 | protein_coding | tolerated(0.15) | benign(0.031) | TCGA-AO-A1KS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PTGIS | SNV | Missense_Mutation | c.1109N>A | p.Ala370Glu | p.A370E | Q16647 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-E9-A247-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PTGIS | SNV | Missense_Mutation | c.1255N>T | p.Asp419Tyr | p.D419Y | Q16647 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTGIS | SNV | Missense_Mutation | rs747466331 | c.805N>C | p.Ser269Pro | p.S269P | Q16647 | protein_coding | tolerated(0.48) | benign(0.255) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTGIS | SNV | Missense_Mutation | c.356A>C | p.Asp119Ala | p.D119A | Q16647 | protein_coding | tolerated(0.62) | benign(0.003) | TCGA-AA-3973-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5740 | PTGIS | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | PHENYLBUTAZONE | PHENYLBUTAZONE | ||
5740 | PTGIS | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | PHENYLBUTAZONE | PHENYLBUTAZONE | ||
5740 | PTGIS | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | inhibitor | 252827453 |
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