Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19001021 | Liver | HCC | negative regulation of endoplasmic reticulum unfolded protein response | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:00364901 | Liver | HCC | regulation of translation in response to endoplasmic reticulum stress | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
GO:190389711 | Liver | HCC | regulation of PERK-mediated unfolded protein response | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
GO:003497620 | Oral cavity | OSCC | response to endoplasmic reticulum stress | 178/7305 | 256/18723 | 2.59e-23 | 6.06e-21 | 178 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
GO:003596620 | Oral cavity | OSCC | response to topologically incorrect protein | 117/7305 | 159/18723 | 6.93e-19 | 8.60e-17 | 117 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:000698620 | Oral cavity | OSCC | response to unfolded protein | 103/7305 | 137/18723 | 6.47e-18 | 6.50e-16 | 103 |
GO:000030220 | Oral cavity | OSCC | response to reactive oxygen species | 143/7305 | 222/18723 | 1.32e-14 | 7.88e-13 | 143 |
GO:00064469 | Oral cavity | OSCC | regulation of translational initiation | 64/7305 | 79/18723 | 2.32e-14 | 1.30e-12 | 64 |
GO:004254219 | Oral cavity | OSCC | response to hydrogen peroxide | 101/7305 | 146/18723 | 1.30e-13 | 6.66e-12 | 101 |
GO:001056320 | Oral cavity | OSCC | negative regulation of phosphorus metabolic process | 246/7305 | 442/18723 | 6.12e-13 | 2.89e-11 | 246 |
GO:004593620 | Oral cavity | OSCC | negative regulation of phosphate metabolic process | 245/7305 | 441/18723 | 8.85e-13 | 4.09e-11 | 245 |
GO:003596720 | Oral cavity | OSCC | cellular response to topologically incorrect protein | 83/7305 | 116/18723 | 1.09e-12 | 4.84e-11 | 83 |
GO:003462019 | Oral cavity | OSCC | cellular response to unfolded protein | 71/7305 | 96/18723 | 3.45e-12 | 1.35e-10 | 71 |
GO:004232619 | Oral cavity | OSCC | negative regulation of phosphorylation | 214/7305 | 385/18723 | 2.30e-11 | 7.74e-10 | 214 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:000193319 | Oral cavity | OSCC | negative regulation of protein phosphorylation | 191/7305 | 342/18723 | 1.58e-10 | 4.62e-09 | 191 |
GO:190589720 | Oral cavity | OSCC | regulation of response to endoplasmic reticulum stress | 60/7305 | 82/18723 | 3.38e-10 | 9.11e-09 | 60 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R15B | SNV | Missense_Mutation | novel | c.1677N>A | p.Phe559Leu | p.F559L | Q5SWA1 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
PPP1R15B | SNV | Missense_Mutation | | c.171G>C | p.Glu57Asp | p.E57D | Q5SWA1 | protein_coding | deleterious_low_confidence(0.04) | benign(0.073) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PPP1R15B | SNV | Missense_Mutation | | c.1861G>A | p.Asp621Asn | p.D621N | Q5SWA1 | protein_coding | tolerated(0.1) | benign(0.149) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPP1R15B | SNV | Missense_Mutation | | c.1341N>A | p.Asp447Glu | p.D447E | Q5SWA1 | protein_coding | tolerated(0.2) | possibly_damaging(0.693) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R15B | SNV | Missense_Mutation | | c.742N>C | p.Val248Leu | p.V248L | Q5SWA1 | protein_coding | deleterious(0.03) | benign(0.159) | TCGA-E9-A244-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PPP1R15B | SNV | Missense_Mutation | novel | c.1531G>C | p.Glu511Gln | p.E511Q | Q5SWA1 | protein_coding | tolerated(0.3) | benign(0.177) | TCGA-LL-A5YM-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unspecific | letrozole | PD |
PPP1R15B | insertion | Frame_Shift_Ins | novel | c.1228_1229insCC | p.Glu410AlafsTer17 | p.E410Afs*17 | Q5SWA1 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R15B | insertion | Frame_Shift_Ins | novel | c.1226_1227insTGGCCTTCCAAAGTGCTGGGATTACAGGCGTG | p.Glu410GlyfsTer27 | p.E410Gfs*27 | Q5SWA1 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R15B | insertion | Frame_Shift_Ins | novel | c.1024_1025insGTCCATTGTGGCCATTTCTGAGTGTC | p.Asn342SerfsTer33 | p.N342Sfs*33 | Q5SWA1 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R15B | insertion | Frame_Shift_Ins | novel | c.181_182insTTCTTAGTTGGGAATATTCTGAAAGAATTGGTAGCATAAAGGG | p.Ser61IlefsTer95 | p.S61Ifs*95 | Q5SWA1 | protein_coding | | | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |