Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/PATJ_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PATJ_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PATJ_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PATJ_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PATJ_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PATJ_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PATJ_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PATJ_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PATJ_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PATJ_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071637 | Lung | IAC | establishment or maintenance of cell polarity | 61/2061 | 218/18723 | 3.10e-12 | 3.07e-09 | 61 |
GO:00300107 | Lung | IAC | establishment of cell polarity | 46/2061 | 143/18723 | 7.70e-12 | 4.27e-09 | 46 |
GO:00343297 | Lung | IAC | cell junction assembly | 86/2061 | 420/18723 | 7.98e-09 | 1.10e-06 | 86 |
GO:00452168 | Lung | IAC | cell-cell junction organization | 43/2061 | 200/18723 | 1.21e-05 | 3.64e-04 | 43 |
GO:01201926 | Lung | IAC | tight junction assembly | 20/2061 | 74/18723 | 1.03e-04 | 2.02e-03 | 20 |
GO:01201936 | Lung | IAC | tight junction organization | 21/2061 | 80/18723 | 1.11e-04 | 2.14e-03 | 21 |
GO:00070438 | Lung | IAC | cell-cell junction assembly | 31/2061 | 146/18723 | 2.38e-04 | 4.06e-03 | 31 |
GO:00705073 | Lung | IAC | regulation of microtubule cytoskeleton organization | 29/2061 | 148/18723 | 1.44e-03 | 1.55e-02 | 29 |
GO:00350885 | Lung | IAC | establishment or maintenance of apical/basal cell polarity | 13/2061 | 49/18723 | 1.95e-03 | 1.97e-02 | 13 |
GO:00612455 | Lung | IAC | establishment or maintenance of bipolar cell polarity | 13/2061 | 49/18723 | 1.95e-03 | 1.97e-02 | 13 |
GO:00611622 | Lung | IAC | establishment of monopolar cell polarity | 8/2061 | 24/18723 | 3.09e-03 | 2.71e-02 | 8 |
GO:0061339 | Lung | IAC | establishment or maintenance of monopolar cell polarity | 8/2061 | 25/18723 | 4.11e-03 | 3.32e-02 | 8 |
GO:000716313 | Lung | AIS | establishment or maintenance of cell polarity | 56/1849 | 218/18723 | 1.31e-11 | 6.13e-09 | 56 |
GO:003001013 | Lung | AIS | establishment of cell polarity | 42/1849 | 143/18723 | 5.03e-11 | 1.95e-08 | 42 |
GO:003432912 | Lung | AIS | cell junction assembly | 84/1849 | 420/18723 | 2.16e-10 | 5.71e-08 | 84 |
GO:004521613 | Lung | AIS | cell-cell junction organization | 41/1849 | 200/18723 | 4.66e-06 | 2.31e-04 | 41 |
GO:000704313 | Lung | AIS | cell-cell junction assembly | 31/1849 | 146/18723 | 3.18e-05 | 1.01e-03 | 31 |
GO:012019312 | Lung | AIS | tight junction organization | 20/1849 | 80/18723 | 7.41e-05 | 1.93e-03 | 20 |
GO:012019212 | Lung | AIS | tight junction assembly | 19/1849 | 74/18723 | 7.55e-05 | 1.94e-03 | 19 |
GO:007050712 | Lung | AIS | regulation of microtubule cytoskeleton organization | 28/1849 | 148/18723 | 5.69e-04 | 8.89e-03 | 28 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PATJ | SNV | Missense_Mutation | novel | c.5322G>T | p.Met1774Ile | p.M1774I | Q8NI35 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
PATJ | SNV | Missense_Mutation | | c.3506N>C | p.Val1169Ala | p.V1169A | Q8NI35 | protein_coding | tolerated(0.15) | benign(0.014) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PATJ | SNV | Missense_Mutation | | c.2263G>A | p.Glu755Lys | p.E755K | Q8NI35 | protein_coding | deleterious(0.01) | benign(0.371) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PATJ | SNV | Missense_Mutation | | c.2825C>G | p.Pro942Arg | p.P942R | Q8NI35 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PATJ | SNV | Missense_Mutation | novel | c.4307T>A | p.Met1436Lys | p.M1436K | Q8NI35 | protein_coding | deleterious(0.02) | possibly_damaging(0.682) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PATJ | SNV | Missense_Mutation | rs776176524 | c.1849N>T | p.Arg617Cys | p.R617C | Q8NI35 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1EY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PATJ | SNV | Missense_Mutation | | c.2804C>T | p.Ala935Val | p.A935V | Q8NI35 | protein_coding | tolerated(0.53) | benign(0) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
PATJ | SNV | Missense_Mutation | | c.3960N>C | p.Arg1320Ser | p.R1320S | Q8NI35 | protein_coding | deleterious(0.02) | probably_damaging(0.976) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PATJ | SNV | Missense_Mutation | | c.3743G>A | p.Gly1248Glu | p.G1248E | Q8NI35 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
PATJ | SNV | Missense_Mutation | novel | c.2752N>G | p.Pro918Ala | p.P918A | Q8NI35 | protein_coding | tolerated(0.17) | benign(0) | TCGA-LD-A66U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |