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Gene: NINJ1 |
Gene summary for NINJ1 |
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Gene information | Species | Human | Gene symbol | NINJ1 | Gene ID | 4814 |
Gene name | ninjurin 1 | |
Gene Alias | NIN1 | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q92982 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4814 | NINJ1 | GSM4909282 | Human | Breast | IDC | 1.94e-16 | 5.80e-01 | -0.0288 |
4814 | NINJ1 | GSM4909291 | Human | Breast | IDC | 1.00e-08 | 4.89e-01 | 0.1753 |
4814 | NINJ1 | GSM4909296 | Human | Breast | IDC | 1.93e-09 | 1.45e-01 | 0.1524 |
4814 | NINJ1 | GSM4909297 | Human | Breast | IDC | 2.96e-05 | -8.99e-02 | 0.1517 |
4814 | NINJ1 | GSM4909298 | Human | Breast | IDC | 1.08e-02 | 2.09e-01 | 0.1551 |
4814 | NINJ1 | GSM4909302 | Human | Breast | IDC | 1.88e-13 | 5.19e-01 | 0.1545 |
4814 | NINJ1 | GSM4909305 | Human | Breast | IDC | 1.70e-03 | 3.28e-01 | 0.0436 |
4814 | NINJ1 | GSM4909306 | Human | Breast | IDC | 9.17e-13 | 4.83e-01 | 0.1564 |
4814 | NINJ1 | GSM4909311 | Human | Breast | IDC | 1.50e-26 | -2.05e-02 | 0.1534 |
4814 | NINJ1 | GSM4909312 | Human | Breast | IDC | 1.87e-10 | 1.83e-01 | 0.1552 |
4814 | NINJ1 | GSM4909319 | Human | Breast | IDC | 5.10e-33 | 7.05e-02 | 0.1563 |
4814 | NINJ1 | GSM4909321 | Human | Breast | IDC | 1.87e-10 | 5.19e-02 | 0.1559 |
4814 | NINJ1 | brca2 | Human | Breast | Precancer | 1.44e-04 | 2.58e-01 | -0.024 |
4814 | NINJ1 | NCCBC14 | Human | Breast | DCIS | 6.54e-05 | 9.35e-02 | 0.2021 |
4814 | NINJ1 | P1 | Human | Breast | IDC | 1.42e-07 | -2.53e-01 | 0.1527 |
4814 | NINJ1 | DCIS2 | Human | Breast | DCIS | 3.97e-13 | -2.68e-01 | 0.0085 |
4814 | NINJ1 | LZE4T | Human | Esophagus | ESCC | 2.70e-13 | 4.28e-01 | 0.0811 |
4814 | NINJ1 | LZE7T | Human | Esophagus | ESCC | 6.02e-13 | 8.69e-01 | 0.0667 |
4814 | NINJ1 | LZE8T | Human | Esophagus | ESCC | 5.90e-08 | 6.02e-01 | 0.067 |
4814 | NINJ1 | LZE20T | Human | Esophagus | ESCC | 4.69e-02 | 3.32e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00702656 | Thyroid | PTC | necrotic cell death | 29/5968 | 62/18723 | 9.96e-03 | 4.07e-02 | 29 |
GO:004269216 | Thyroid | ATC | muscle cell differentiation | 165/6293 | 384/18723 | 7.17e-05 | 5.46e-04 | 165 |
GO:003109932 | Thyroid | ATC | regeneration | 91/6293 | 198/18723 | 1.95e-04 | 1.31e-03 | 91 |
GO:003210324 | Thyroid | ATC | positive regulation of response to external stimulus | 178/6293 | 427/18723 | 2.61e-04 | 1.67e-03 | 178 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
GO:004576621 | Thyroid | ATC | positive regulation of angiogenesis | 82/6293 | 181/18723 | 6.79e-04 | 3.83e-03 | 82 |
GO:190401821 | Thyroid | ATC | positive regulation of vasculature development | 82/6293 | 181/18723 | 6.79e-04 | 3.83e-03 | 82 |
GO:00457657 | Thyroid | ATC | regulation of angiogenesis | 141/6293 | 342/18723 | 1.80e-03 | 8.85e-03 | 141 |
GO:19013427 | Thyroid | ATC | regulation of vasculature development | 143/6293 | 348/18723 | 1.95e-03 | 9.44e-03 | 143 |
GO:007026512 | Thyroid | ATC | necrotic cell death | 30/6293 | 62/18723 | 1.12e-02 | 4.00e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NINJ1 | SNV | Missense_Mutation | rs762750806 | c.280N>A | p.Val94Met | p.V94M | Q92982 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A6-6782-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | rs755546683 | c.337G>A | p.Ala113Thr | p.A113T | Q92982 | protein_coding | tolerated(0.4) | possibly_damaging(0.532) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | rs540681874 | c.388G>A | p.Val130Met | p.V130M | Q92982 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | c.236N>A | p.Pro79His | p.P79H | Q92982 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NINJ1 | SNV | Missense_Mutation | novel | c.386N>G | p.Ile129Ser | p.I129S | Q92982 | protein_coding | deleterious(0.02) | possibly_damaging(0.74) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | novel | c.163N>A | p.Ala55Thr | p.A55T | Q92982 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | novel | c.244N>A | p.Val82Ile | p.V82I | Q92982 | protein_coding | tolerated(0.21) | benign(0.056) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | rs202187907 | c.368N>T | p.Thr123Met | p.T123M | Q92982 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
NINJ1 | SNV | Missense_Mutation | novel | c.412N>A | p.Ala138Thr | p.A138T | Q92982 | protein_coding | tolerated(0.05) | possibly_damaging(0.859) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NINJ1 | SNV | Missense_Mutation | novel | c.418N>A | p.Gly140Arg | p.G140R | Q92982 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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