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Gene: NDFIP1 |
Gene summary for NDFIP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NDFIP1 | Gene ID | 80762 |
Gene name | Nedd4 family interacting protein 1 | |
Gene Alias | N4WBP5 | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q9BT67 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80762 | NDFIP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.02e-06 | 4.72e-01 | -0.1088 |
80762 | NDFIP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.24e-12 | 4.51e-01 | -0.1954 |
80762 | NDFIP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.60e-06 | 3.32e-01 | 0.294 |
80762 | NDFIP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.08e-03 | 9.59e-01 | 0.3487 |
80762 | NDFIP1 | A015-C-203 | Human | Colorectum | FAP | 2.25e-05 | -1.75e-01 | -0.1294 |
80762 | NDFIP1 | A001-C-108 | Human | Colorectum | FAP | 4.25e-03 | -1.34e-01 | -0.0272 |
80762 | NDFIP1 | A002-C-205 | Human | Colorectum | FAP | 3.98e-03 | -1.86e-01 | -0.1236 |
80762 | NDFIP1 | A015-C-104 | Human | Colorectum | FAP | 3.51e-06 | -1.90e-01 | -0.1899 |
80762 | NDFIP1 | A001-C-014 | Human | Colorectum | FAP | 2.57e-02 | -9.01e-02 | 0.0135 |
80762 | NDFIP1 | A002-C-116 | Human | Colorectum | FAP | 4.38e-04 | -1.52e-01 | -0.0452 |
80762 | NDFIP1 | A018-E-020 | Human | Colorectum | FAP | 3.49e-02 | -1.80e-01 | -0.2034 |
80762 | NDFIP1 | F034 | Human | Colorectum | FAP | 1.80e-02 | -1.62e-01 | -0.0665 |
80762 | NDFIP1 | AEH-subject1 | Human | Endometrium | AEH | 6.57e-03 | -2.00e-01 | -0.3059 |
80762 | NDFIP1 | AEH-subject2 | Human | Endometrium | AEH | 1.05e-13 | -3.00e-01 | -0.2525 |
80762 | NDFIP1 | AEH-subject3 | Human | Endometrium | AEH | 2.94e-05 | -1.94e-01 | -0.2576 |
80762 | NDFIP1 | AEH-subject4 | Human | Endometrium | AEH | 3.65e-06 | -1.76e-01 | -0.2657 |
80762 | NDFIP1 | AEH-subject5 | Human | Endometrium | AEH | 7.91e-03 | -2.62e-01 | -0.2953 |
80762 | NDFIP1 | EEC-subject1 | Human | Endometrium | EEC | 6.41e-10 | -1.68e-01 | -0.2682 |
80762 | NDFIP1 | EEC-subject2 | Human | Endometrium | EEC | 5.76e-14 | -3.79e-01 | -0.2607 |
80762 | NDFIP1 | EEC-subject3 | Human | Endometrium | EEC | 2.25e-28 | -3.88e-01 | -0.2525 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332213 | Endometrium | EEC | positive regulation of protein modification by small protein conjugation or removal | 33/2168 | 138/18723 | 3.49e-05 | 5.90e-04 | 33 |
GO:004211014 | Endometrium | EEC | T cell activation | 85/2168 | 487/18723 | 6.81e-05 | 1.01e-03 | 85 |
GO:003139813 | Endometrium | EEC | positive regulation of protein ubiquitination | 29/2168 | 119/18723 | 7.05e-05 | 1.04e-03 | 29 |
GO:190370615 | Endometrium | EEC | regulation of hemopoiesis | 67/2168 | 367/18723 | 1.01e-04 | 1.40e-03 | 67 |
GO:000715914 | Endometrium | EEC | leukocyte cell-cell adhesion | 67/2168 | 371/18723 | 1.41e-04 | 1.82e-03 | 67 |
GO:005086313 | Endometrium | EEC | regulation of T cell activation | 60/2168 | 329/18723 | 2.33e-04 | 2.75e-03 | 60 |
GO:005105111 | Endometrium | EEC | negative regulation of transport | 80/2168 | 470/18723 | 2.53e-04 | 2.93e-03 | 80 |
GO:004563717 | Endometrium | EEC | regulation of myeloid cell differentiation | 42/2168 | 210/18723 | 2.72e-04 | 3.09e-03 | 42 |
GO:190303713 | Endometrium | EEC | regulation of leukocyte cell-cell adhesion | 60/2168 | 336/18723 | 4.13e-04 | 4.36e-03 | 60 |
GO:000716214 | Endometrium | EEC | negative regulation of cell adhesion | 54/2168 | 303/18723 | 8.19e-04 | 7.62e-03 | 54 |
GO:000268313 | Endometrium | EEC | negative regulation of immune system process | 72/2168 | 434/18723 | 1.04e-03 | 9.13e-03 | 72 |
GO:003009917 | Endometrium | EEC | myeloid cell differentiation | 64/2168 | 381/18723 | 1.40e-03 | 1.14e-02 | 64 |
GO:004209814 | Endometrium | EEC | T cell proliferation | 37/2168 | 199/18723 | 2.40e-03 | 1.77e-02 | 37 |
GO:004212913 | Endometrium | EEC | regulation of T cell proliferation | 32/2168 | 171/18723 | 4.09e-03 | 2.69e-02 | 32 |
GO:19021057 | Endometrium | EEC | regulation of leukocyte differentiation | 47/2168 | 279/18723 | 5.30e-03 | 3.29e-02 | 47 |
GO:007066313 | Endometrium | EEC | regulation of leukocyte proliferation | 42/2168 | 245/18723 | 5.94e-03 | 3.54e-02 | 42 |
GO:000703413 | Endometrium | EEC | vacuolar transport | 29/2168 | 157/18723 | 7.29e-03 | 4.15e-02 | 29 |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDFIP1 | insertion | Frame_Shift_Ins | novel | c.521_522insGCCAAAAC | p.Phe174LeufsTer17 | p.F174Lfs*17 | Q9BT67 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NDFIP1 | SNV | Missense_Mutation | novel | c.343N>T | p.Asp115Tyr | p.D115Y | Q9BT67 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NDFIP1 | SNV | Missense_Mutation | c.292N>G | p.Phe98Val | p.F98V | Q9BT67 | protein_coding | tolerated(0.19) | possibly_damaging(0.572) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NDFIP1 | SNV | Missense_Mutation | c.607N>T | p.Arg203Trp | p.R203W | Q9BT67 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NDFIP1 | insertion | Frame_Shift_Ins | novel | c.368dupT | p.Met124HisfsTer6 | p.M124Hfs*6 | Q9BT67 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NDFIP1 | insertion | Frame_Shift_Ins | novel | c.194dupC | p.Ser66IlefsTer12 | p.S66Ifs*12 | Q9BT67 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
NDFIP1 | SNV | Missense_Mutation | novel | c.627N>A | p.Phe209Leu | p.F209L | Q9BT67 | protein_coding | tolerated(0.65) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NDFIP1 | SNV | Missense_Mutation | novel | c.288N>T | p.Glu96Asp | p.E96D | Q9BT67 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NDFIP1 | SNV | Missense_Mutation | novel | c.214N>G | p.Thr72Ala | p.T72A | Q9BT67 | protein_coding | deleterious(0.05) | benign(0.277) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NDFIP1 | SNV | Missense_Mutation | c.644N>A | p.Thr215Asn | p.T215N | Q9BT67 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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