Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/N4BP2L2_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/N4BP2L2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/N4BP2L2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/N4BP2L2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/N4BP2L2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/N4BP2L2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/N4BP2L2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/N4BP2L2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/N4BP2L2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/N4BP2L2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/N4BP2L2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/N4BP2L2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200073715 | Skin | cSCC | negative regulation of stem cell differentiation | 16/4864 | 23/18723 | 1.47e-05 | 1.82e-04 | 16 |
GO:190203611 | Skin | cSCC | regulation of hematopoietic stem cell differentiation | 9/4864 | 14/18723 | 2.87e-03 | 1.60e-02 | 9 |
GO:190153211 | Skin | cSCC | regulation of hematopoietic progenitor cell differentiation | 16/4864 | 32/18723 | 3.04e-03 | 1.67e-02 | 16 |
GO:006021812 | Skin | cSCC | hematopoietic stem cell differentiation | 15/4864 | 30/18723 | 4.07e-03 | 2.16e-02 | 15 |
GO:000224413 | Skin | cSCC | hematopoietic progenitor cell differentiation | 42/4864 | 114/18723 | 6.74e-03 | 3.27e-02 | 42 |
GO:004886317 | Skin | cSCC | stem cell differentiation | 69/4864 | 206/18723 | 9.56e-03 | 4.30e-02 | 69 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
GO:20007367 | Thyroid | PTC | regulation of stem cell differentiation | 32/5968 | 58/18723 | 2.01e-04 | 1.50e-03 | 32 |
GO:200073716 | Thyroid | PTC | negative regulation of stem cell differentiation | 16/5968 | 23/18723 | 2.31e-04 | 1.67e-03 | 16 |
GO:00018246 | Thyroid | PTC | blastocyst development | 49/5968 | 106/18723 | 1.37e-03 | 7.72e-03 | 49 |
GO:004886318 | Thyroid | PTC | stem cell differentiation | 85/5968 | 206/18723 | 2.71e-03 | 1.36e-02 | 85 |
GO:19015325 | Thyroid | PTC | regulation of hematopoietic progenitor cell differentiation | 18/5968 | 32/18723 | 3.72e-03 | 1.79e-02 | 18 |
GO:00602187 | Thyroid | PTC | hematopoietic stem cell differentiation | 17/5968 | 30/18723 | 4.31e-03 | 2.04e-02 | 17 |
GO:19020365 | Thyroid | PTC | regulation of hematopoietic stem cell differentiation | 9/5968 | 14/18723 | 1.27e-02 | 4.92e-02 | 9 |
GO:000170126 | Thyroid | ATC | in utero embryonic development | 183/6293 | 367/18723 | 6.62e-11 | 2.11e-09 | 183 |
GO:004886321 | Thyroid | ATC | stem cell differentiation | 97/6293 | 206/18723 | 3.88e-05 | 3.15e-04 | 97 |
GO:200073616 | Thyroid | ATC | regulation of stem cell differentiation | 33/6293 | 58/18723 | 2.25e-04 | 1.46e-03 | 33 |
GO:000182414 | Thyroid | ATC | blastocyst development | 53/6293 | 106/18723 | 3.48e-04 | 2.16e-03 | 53 |
GO:200073721 | Thyroid | ATC | negative regulation of stem cell differentiation | 16/6293 | 23/18723 | 4.58e-04 | 2.71e-03 | 16 |
GO:190153212 | Thyroid | ATC | regulation of hematopoietic progenitor cell differentiation | 19/6293 | 32/18723 | 2.46e-03 | 1.14e-02 | 19 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
N4BP2L2 | SNV | Missense_Mutation | | c.907N>T | p.His303Tyr | p.H303Y | Q92802 | protein_coding | deleterious(0.02) | benign(0.047) | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
N4BP2L2 | SNV | Missense_Mutation | novel | c.1801N>A | p.His601Asn | p.H601N | Q92802 | protein_coding | deleterious(0.03) | benign(0.08) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
N4BP2L2 | SNV | Missense_Mutation | novel | c.1452T>A | p.Asn484Lys | p.N484K | Q92802 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-BH-A0BO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
N4BP2L2 | SNV | Missense_Mutation | | c.294N>C | p.Lys98Asn | p.K98N | Q92802 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
N4BP2L2 | insertion | Frame_Shift_Ins | novel | c.105_106insCTTTTTACTTTGTGCTTTCATGTTGCTCCCACTTT | p.Ala36LeufsTer22 | p.A36Lfs*22 | Q92802 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
N4BP2L2 | SNV | Missense_Mutation | | c.1861G>A | p.Glu621Lys | p.E621K | Q92802 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
N4BP2L2 | SNV | Missense_Mutation | novel | c.172C>T | p.Pro58Ser | p.P58S | Q92802 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
N4BP2L2 | SNV | Missense_Mutation | novel | c.459N>T | p.Gln153His | p.Q153H | Q92802 | protein_coding | deleterious(0) | possibly_damaging(0.61) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
N4BP2L2 | insertion | Frame_Shift_Ins | novel | c.1700dupC | p.Leu568PhefsTer4 | p.L568Ffs*4 | Q92802 | protein_coding | | | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
N4BP2L2 | SNV | Missense_Mutation | | c.230C>G | p.Thr77Ser | p.T77S | Q92802 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-2684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |