![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MTAP |
Gene summary for MTAP |
![]() |
Gene information | Species | Human | Gene symbol | MTAP | Gene ID | 4507 |
Gene name | methylthioadenosine phosphorylase | |
Gene Alias | BDMF | |
Cytomap | 9p21.3 | |
Gene Type | protein-coding | GO ID | GO:0000096 | UniProtAcc | Q13126 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4507 | MTAP | LZE4T | Human | Esophagus | ESCC | 5.69e-07 | 2.28e-01 | 0.0811 |
4507 | MTAP | LZE7T | Human | Esophagus | ESCC | 3.39e-06 | 4.94e-01 | 0.0667 |
4507 | MTAP | LZE20T | Human | Esophagus | ESCC | 8.15e-05 | 1.08e-01 | 0.0662 |
4507 | MTAP | LZE24T | Human | Esophagus | ESCC | 1.24e-14 | 3.49e-01 | 0.0596 |
4507 | MTAP | LZE21T | Human | Esophagus | ESCC | 1.12e-03 | 2.97e-01 | 0.0655 |
4507 | MTAP | P2T-E | Human | Esophagus | ESCC | 5.76e-19 | 2.91e-01 | 0.1177 |
4507 | MTAP | P4T-E | Human | Esophagus | ESCC | 6.98e-07 | 1.39e-01 | 0.1323 |
4507 | MTAP | P11T-E | Human | Esophagus | ESCC | 3.58e-15 | 1.16e+00 | 0.1426 |
4507 | MTAP | P15T-E | Human | Esophagus | ESCC | 4.67e-06 | 1.32e-01 | 0.1149 |
4507 | MTAP | P16T-E | Human | Esophagus | ESCC | 5.13e-07 | 1.04e-01 | 0.1153 |
4507 | MTAP | P21T-E | Human | Esophagus | ESCC | 1.90e-16 | 2.33e-01 | 0.1617 |
4507 | MTAP | P22T-E | Human | Esophagus | ESCC | 1.42e-18 | 7.71e-02 | 0.1236 |
4507 | MTAP | P23T-E | Human | Esophagus | ESCC | 1.12e-13 | 2.91e-01 | 0.108 |
4507 | MTAP | P24T-E | Human | Esophagus | ESCC | 2.84e-13 | 5.52e-02 | 0.1287 |
4507 | MTAP | P26T-E | Human | Esophagus | ESCC | 2.95e-17 | 2.27e-01 | 0.1276 |
4507 | MTAP | P27T-E | Human | Esophagus | ESCC | 7.53e-12 | 9.29e-02 | 0.1055 |
4507 | MTAP | P28T-E | Human | Esophagus | ESCC | 4.97e-28 | 4.97e-01 | 0.1149 |
4507 | MTAP | P30T-E | Human | Esophagus | ESCC | 4.21e-04 | 1.16e-01 | 0.137 |
4507 | MTAP | P32T-E | Human | Esophagus | ESCC | 6.08e-11 | 2.29e-01 | 0.1666 |
4507 | MTAP | P36T-E | Human | Esophagus | ESCC | 1.93e-08 | 2.79e-01 | 0.1187 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016077 | Thyroid | PTC | alpha-amino acid biosynthetic process | 33/5968 | 68/18723 | 3.04e-03 | 1.50e-02 | 33 |
GO:00442726 | Thyroid | PTC | sulfur compound biosynthetic process | 63/5968 | 148/18723 | 3.91e-03 | 1.87e-02 | 63 |
GO:00086527 | Thyroid | PTC | cellular amino acid biosynthetic process | 35/5968 | 76/18723 | 6.68e-03 | 2.89e-02 | 35 |
GO:00000963 | Thyroid | PTC | sulfur amino acid metabolic process | 18/5968 | 34/18723 | 8.65e-03 | 3.62e-02 | 18 |
GO:190165427 | Thyroid | ATC | response to ketone | 105/6293 | 194/18723 | 2.96e-09 | 6.96e-08 | 105 |
GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
GO:007252223 | Thyroid | ATC | purine-containing compound biosynthetic process | 92/6293 | 200/18723 | 1.74e-04 | 1.18e-03 | 92 |
GO:000906711 | Thyroid | ATC | aspartate family amino acid biosynthetic process | 15/6293 | 21/18723 | 4.45e-04 | 2.64e-03 | 15 |
GO:000865212 | Thyroid | ATC | cellular amino acid biosynthetic process | 39/6293 | 76/18723 | 1.07e-03 | 5.63e-03 | 39 |
GO:003357417 | Thyroid | ATC | response to testosterone | 24/6293 | 42/18723 | 1.45e-03 | 7.47e-03 | 24 |
GO:190160712 | Thyroid | ATC | alpha-amino acid biosynthetic process | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
GO:004427212 | Thyroid | ATC | sulfur compound biosynthetic process | 66/6293 | 148/18723 | 3.43e-03 | 1.53e-02 | 66 |
GO:000908611 | Thyroid | ATC | methionine biosynthetic process | 9/6293 | 12/18723 | 4.10e-03 | 1.75e-02 | 9 |
GO:000655511 | Thyroid | ATC | methionine metabolic process | 11/6293 | 16/18723 | 4.33e-03 | 1.80e-02 | 11 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTAP | SNV | Missense_Mutation | novel | c.796A>C | p.Thr266Pro | p.T266P | Q13126 | protein_coding | tolerated(0.15) | possibly_damaging(0.491) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MTAP | SNV | Missense_Mutation | novel | c.796N>C | p.Thr266Pro | p.T266P | Q13126 | protein_coding | tolerated(0.15) | possibly_damaging(0.491) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTAP | SNV | Missense_Mutation | novel | c.610N>T | p.Leu204Phe | p.L204F | Q13126 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
MTAP | SNV | Missense_Mutation | rs200708704 | c.572N>T | p.Ala191Val | p.A191V | Q13126 | protein_coding | deleterious(0.02) | possibly_damaging(0.77) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
MTAP | SNV | Missense_Mutation | novel | c.819N>A | p.Met273Ile | p.M273I | Q13126 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
MTAP | SNV | Missense_Mutation | c.508N>A | p.Val170Ile | p.V170I | Q13126 | protein_coding | tolerated(0.43) | benign(0.007) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTAP | SNV | Missense_Mutation | novel | c.319N>C | p.Ile107Leu | p.I107L | Q13126 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTAP | SNV | Missense_Mutation | novel | c.316N>A | p.Asp106Asn | p.D106N | Q13126 | protein_coding | deleterious(0.03) | benign(0.34) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MTAP | SNV | Missense_Mutation | c.527G>A | p.Arg176His | p.R176H | Q13126 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MTAP | SNV | Missense_Mutation | novel | c.125C>A | p.Ser42Tyr | p.S42Y | Q13126 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4507 | MTAP | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | L-ALANOSINE | ALANOSINE | 16505107 | |
4507 | MTAP | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | DIFLUOROMETHYLORNITHINE | 15534104 |
Page: 1 |