Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MCTS1

Gene summary for MCTS1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MCTS1

Gene ID

28985

Gene nameMCTS1 re-initiation and release factor
Gene AliasMCT-1
CytomapXq24
Gene Typeprotein-coding
GO ID

GO:0001731

UniProtAcc

Q9ULC4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
28985MCTS1LZE4THumanEsophagusESCC2.76e-143.29e-010.0811
28985MCTS1LZE7THumanEsophagusESCC1.15e-119.32e-010.0667
28985MCTS1LZE8THumanEsophagusESCC2.33e-032.98e-010.067
28985MCTS1LZE20THumanEsophagusESCC3.47e-033.43e-010.0662
28985MCTS1LZE22D1HumanEsophagusHGIN8.19e-037.41e-020.0595
28985MCTS1LZE24THumanEsophagusESCC5.85e-311.03e+000.0596
28985MCTS1LZE21THumanEsophagusESCC9.48e-065.74e-010.0655
28985MCTS1LZE6THumanEsophagusESCC9.21e-106.29e-010.0845
28985MCTS1P1T-EHumanEsophagusESCC1.20e-106.33e-010.0875
28985MCTS1P2T-EHumanEsophagusESCC9.61e-346.86e-010.1177
28985MCTS1P4T-EHumanEsophagusESCC3.08e-441.10e+000.1323
28985MCTS1P5T-EHumanEsophagusESCC1.96e-461.00e+000.1327
28985MCTS1P8T-EHumanEsophagusESCC1.85e-235.85e-010.0889
28985MCTS1P9T-EHumanEsophagusESCC1.46e-421.08e+000.1131
28985MCTS1P10T-EHumanEsophagusESCC1.62e-541.11e+000.116
28985MCTS1P11T-EHumanEsophagusESCC7.38e-158.66e-010.1426
28985MCTS1P12T-EHumanEsophagusESCC3.32e-234.72e-010.1122
28985MCTS1P15T-EHumanEsophagusESCC2.21e-286.31e-010.1149
28985MCTS1P16T-EHumanEsophagusESCC1.42e-193.91e-010.1153
28985MCTS1P17T-EHumanEsophagusESCC1.22e-137.26e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190300814ProstateTumororganelle disassembly41/3246114/187231.41e-062.53e-0541
GO:000173113ProstateTumorformation of translation preinitiation complex7/324611/187238.04e-045.44e-037
GO:002261329SkincSCCribonucleoprotein complex biogenesis302/4864463/187235.13e-723.22e-68302
GO:000218129SkincSCCcytoplasmic translation127/4864148/187234.83e-537.57e-50127
GO:007182629SkincSCCribonucleoprotein complex subunit organization140/4864227/187235.54e-303.16e-27140
GO:002261829SkincSCCribonucleoprotein complex assembly136/4864220/187232.60e-291.25e-26136
GO:001603229SkincSCCviral process211/4864415/187237.04e-282.76e-25211
GO:0006413111SkincSCCtranslational initiation84/4864118/187239.12e-252.29e-2284
GO:0022411112SkincSCCcellular component disassembly201/4864443/187234.09e-195.69e-17201
GO:0002183111SkincSCCcytoplasmic translational initiation30/486434/187233.77e-142.49e-1230
GO:190300817SkincSCCorganelle disassembly65/4864114/187232.03e-121.12e-1065
GO:001908019SkincSCCviral gene expression50/486494/187231.68e-085.04e-0750
GO:001908118SkincSCCviral translation15/486416/187231.97e-085.79e-0715
GO:007552215SkincSCCIRES-dependent viral translational initiation11/486411/187233.61e-077.18e-0611
GO:000173115SkincSCCformation of translation preinitiation complex10/486411/187231.17e-051.50e-0410
GO:0022613113ThyroidPTCribonucleoprotein complex biogenesis292/5968463/187233.24e-442.05e-40292
GO:0002181113ThyroidPTCcytoplasmic translation121/5968148/187234.32e-364.54e-33121
GO:0016032113ThyroidPTCviral process236/5968415/187232.48e-268.24e-24236
GO:0022411113ThyroidPTCcellular component disassembly232/5968443/187231.36e-191.75e-17232
GO:0006413112ThyroidPTCtranslational initiation84/5968118/187231.89e-182.09e-1684
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MCTS1SNVMissense_Mutationrs750185102c.5G>Ap.Gly2Aspp.G2DQ9ULC4protein_codingdeleterious_low_confidence(0)benign(0.07)TCGA-A1-A0SJ-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
MCTS1SNVMissense_Mutationc.81G>Tp.Lys27Asnp.K27NQ9ULC4protein_codingdeleterious(0)probably_damaging(0.944)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MCTS1SNVMissense_Mutationc.433N>Cp.Cys145Argp.C145RQ9ULC4protein_codingdeleterious(0)benign(0.239)TCGA-A6-2684-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
MCTS1SNVMissense_Mutationc.491N>Ap.Gly164Aspp.G164DQ9ULC4protein_codingdeleterious(0.02)benign(0.226)TCGA-AA-3672-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
MCTS1SNVMissense_Mutationc.27A>Cp.Lys9Asnp.K9NQ9ULC4protein_codingdeleterious(0.03)benign(0.267)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
MCTS1SNVMissense_Mutationnovelc.96N>Tp.Glu32Aspp.E32DQ9ULC4protein_codingtolerated(0.28)benign(0)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MCTS1SNVMissense_Mutationc.224G>Ap.Arg75Lysp.R75KQ9ULC4protein_codingtolerated(0.44)benign(0.203)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MCTS1SNVMissense_Mutationnovelc.141N>Tp.Lys47Asnp.K47NQ9ULC4protein_codingdeleterious(0)possibly_damaging(0.847)TCGA-A5-A2K5-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MCTS1SNVMissense_Mutationc.314T>Cp.Phe105Serp.F105SQ9ULC4protein_codingdeleterious(0.03)possibly_damaging(0.455)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MCTS1SNVMissense_Mutationc.398N>Cp.Val133Alap.V133AQ9ULC4protein_codingdeleterious(0.01)probably_damaging(0.956)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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