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Gene: LTF |
Gene summary for LTF |
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Gene information | Species | Human | Gene symbol | LTF | Gene ID | 4057 |
Gene name | lactotransferrin | |
Gene Alias | GIG12 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | P02788 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4057 | LTF | GSM4909281 | Human | Breast | IDC | 5.56e-33 | -1.03e+00 | 0.21 |
4057 | LTF | GSM4909282 | Human | Breast | IDC | 7.90e-28 | -1.02e+00 | -0.0288 |
4057 | LTF | GSM4909285 | Human | Breast | IDC | 2.90e-36 | -1.03e+00 | 0.21 |
4057 | LTF | GSM4909286 | Human | Breast | IDC | 1.04e-39 | -1.06e+00 | 0.1081 |
4057 | LTF | GSM4909290 | Human | Breast | IDC | 5.79e-18 | -9.40e-01 | 0.2096 |
4057 | LTF | GSM4909291 | Human | Breast | IDC | 2.52e-25 | -1.06e+00 | 0.1753 |
4057 | LTF | GSM4909292 | Human | Breast | IDC | 4.67e-03 | -1.02e+00 | 0.1236 |
4057 | LTF | GSM4909293 | Human | Breast | IDC | 1.54e-19 | -8.64e-01 | 0.1581 |
4057 | LTF | GSM4909294 | Human | Breast | IDC | 1.28e-10 | -7.48e-01 | 0.2022 |
4057 | LTF | GSM4909295 | Human | Breast | IDC | 1.79e-02 | -5.38e-01 | 0.0898 |
4057 | LTF | GSM4909296 | Human | Breast | IDC | 1.05e-16 | -8.38e-01 | 0.1524 |
4057 | LTF | GSM4909297 | Human | Breast | IDC | 1.05e-21 | -8.89e-01 | 0.1517 |
4057 | LTF | GSM4909298 | Human | Breast | IDC | 1.27e-22 | -9.17e-01 | 0.1551 |
4057 | LTF | GSM4909299 | Human | Breast | IDC | 8.72e-03 | -3.57e-01 | 0.035 |
4057 | LTF | GSM4909300 | Human | Breast | IDC | 1.24e-10 | 7.27e-01 | 0.0334 |
4057 | LTF | GSM4909301 | Human | Breast | IDC | 2.02e-34 | -1.04e+00 | 0.1577 |
4057 | LTF | GSM4909302 | Human | Breast | IDC | 1.53e-18 | -8.54e-01 | 0.1545 |
4057 | LTF | GSM4909303 | Human | Breast | IDC | 3.43e-06 | -8.90e-01 | 0.0438 |
4057 | LTF | GSM4909304 | Human | Breast | IDC | 3.95e-37 | -1.05e+00 | 0.1636 |
4057 | LTF | GSM4909306 | Human | Breast | IDC | 8.26e-09 | -6.78e-01 | 0.1564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190210611 | Breast | IDC | negative regulation of leukocyte differentiation | 16/1434 | 102/18723 | 4.59e-03 | 3.53e-02 | 16 |
GO:005507212 | Breast | IDC | iron ion homeostasis | 14/1434 | 85/18723 | 4.98e-03 | 3.77e-02 | 14 |
GO:006220811 | Breast | IDC | positive regulation of pattern recognition receptor signaling pathway | 9/1434 | 44/18723 | 5.42e-03 | 4.00e-02 | 9 |
GO:007121911 | Breast | IDC | cellular response to molecule of bacterial origin | 28/1434 | 221/18723 | 5.88e-03 | 4.24e-02 | 28 |
GO:00358214 | Breast | IDC | modulation of process of other organism | 16/1434 | 106/18723 | 6.70e-03 | 4.66e-02 | 16 |
GO:190370711 | Breast | IDC | negative regulation of hemopoiesis | 16/1434 | 106/18723 | 6.70e-03 | 4.66e-02 | 16 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
GO:200011623 | Breast | DCIS | regulation of cysteine-type endopeptidase activity | 54/1390 | 235/18723 | 4.56e-14 | 1.29e-11 | 54 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:001095122 | Breast | DCIS | negative regulation of endopeptidase activity | 47/1390 | 252/18723 | 3.63e-09 | 3.11e-07 | 47 |
GO:200011722 | Breast | DCIS | negative regulation of cysteine-type endopeptidase activity | 24/1390 | 86/18723 | 9.04e-09 | 7.01e-07 | 24 |
GO:001907923 | Breast | DCIS | viral genome replication | 30/1390 | 131/18723 | 2.12e-08 | 1.45e-06 | 30 |
GO:005079222 | Breast | DCIS | regulation of viral process | 34/1390 | 164/18723 | 3.58e-08 | 2.30e-06 | 34 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:003009924 | Breast | DCIS | myeloid cell differentiation | 55/1390 | 381/18723 | 1.50e-06 | 5.68e-05 | 55 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LTF | SNV | Missense_Mutation | novel | c.1299C>G | p.Asn433Lys | p.N433K | P02788 | protein_coding | tolerated(0.1) | probably_damaging(0.927) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
LTF | SNV | Missense_Mutation | c.2090N>T | p.Ser697Leu | p.S697L | P02788 | protein_coding | tolerated(0.21) | benign(0.083) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
LTF | SNV | Missense_Mutation | c.513N>G | p.Phe171Leu | p.F171L | P02788 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
LTF | insertion | Frame_Shift_Ins | novel | c.1876_1877insTGAGAGAGCT | p.Glu626ValfsTer16 | p.E626Vfs*16 | P02788 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LTF | SNV | Missense_Mutation | novel | c.676G>A | p.Ala226Thr | p.A226T | P02788 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LTF | SNV | Missense_Mutation | c.286G>T | p.Val96Leu | p.V96L | P02788 | protein_coding | deleterious(0.03) | possibly_damaging(0.455) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
LTF | SNV | Missense_Mutation | c.1963N>C | p.Ser655Pro | p.S655P | P02788 | protein_coding | deleterious(0.02) | possibly_damaging(0.836) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LTF | SNV | Missense_Mutation | rs776865450 | c.145N>T | p.Arg49Cys | p.R49C | P02788 | protein_coding | deleterious(0.04) | possibly_damaging(0.79) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LTF | SNV | Missense_Mutation | rs776865450 | c.145N>T | p.Arg49Cys | p.R49C | P02788 | protein_coding | deleterious(0.04) | possibly_damaging(0.79) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LTF | SNV | Missense_Mutation | rs765686239 | c.206N>T | p.Ala69Val | p.A69V | P02788 | protein_coding | tolerated(0.24) | benign(0.023) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | BACITRACIN | BACITRACIN | 12042436 | |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | HLF 1-11 | |||
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | Talactoferrin | TALACTOFERRIN ALFA | ||
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | RESERPINE | RESERPINE | 3608900 | |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | Parecoxib | PARECOXIB |
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