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Gene: LEPROT |
Gene summary for LEPROT |
Gene summary. |
Gene information | Species | Human | Gene symbol | LEPROT | Gene ID | 54741 |
Gene name | leptin receptor overlapping transcript | |
Gene Alias | LEPR | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | A0A087X0N2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54741 | LEPROT | CA_HPV_1 | Human | Cervix | CC | 4.34e-08 | -2.96e-01 | 0.0264 |
54741 | LEPROT | CCI_1 | Human | Cervix | CC | 1.11e-08 | -5.13e-01 | 0.528 |
54741 | LEPROT | CCI_2 | Human | Cervix | CC | 6.44e-08 | -5.13e-01 | 0.5249 |
54741 | LEPROT | CCI_3 | Human | Cervix | CC | 9.21e-12 | -5.13e-01 | 0.516 |
54741 | LEPROT | CCII_1 | Human | Cervix | CC | 1.79e-16 | -5.13e-01 | 0.3249 |
54741 | LEPROT | sample1 | Human | Cervix | CC | 2.49e-02 | -3.05e-01 | 0.0959 |
54741 | LEPROT | T1 | Human | Cervix | CC | 1.78e-09 | -3.71e-01 | 0.0918 |
54741 | LEPROT | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-09 | 1.93e-01 | 0.0155 |
54741 | LEPROT | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-13 | 3.64e-01 | -0.1808 |
54741 | LEPROT | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 5.36e-01 | -0.0811 |
54741 | LEPROT | HTA11_78_2000001011 | Human | Colorectum | AD | 1.18e-19 | 5.27e-01 | -0.1088 |
54741 | LEPROT | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-42 | 7.70e-01 | -0.1954 |
54741 | LEPROT | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-10 | 6.00e-01 | -0.2602 |
54741 | LEPROT | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.07e-01 | -0.2196 |
54741 | LEPROT | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.60e-01 | -0.1207 |
54741 | LEPROT | HTA11_83_2000001011 | Human | Colorectum | SER | 7.80e-11 | 3.71e-01 | -0.1526 |
54741 | LEPROT | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-19 | 3.65e-01 | -0.1464 |
54741 | LEPROT | HTA11_866_2000001011 | Human | Colorectum | AD | 1.73e-12 | 2.55e-01 | -0.1001 |
54741 | LEPROT | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.47e-01 | -0.059 |
54741 | LEPROT | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 2.87e-01 | -0.1706 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016532 | Colorectum | MSS | cellular response to peptide | 91/3467 | 359/18723 | 7.38e-04 | 7.88e-03 | 91 |
GO:19038282 | Colorectum | MSS | negative regulation of cellular protein localization | 36/3467 | 117/18723 | 9.19e-04 | 9.34e-03 | 36 |
GO:00713752 | Colorectum | MSS | cellular response to peptide hormone stimulus | 75/3467 | 290/18723 | 1.14e-03 | 1.12e-02 | 75 |
GO:19032142 | Colorectum | MSS | regulation of protein targeting to mitochondrion | 17/3467 | 44/18723 | 1.41e-03 | 1.32e-02 | 17 |
GO:00325092 | Colorectum | MSS | endosome transport via multivesicular body sorting pathway | 13/3467 | 31/18723 | 2.14e-03 | 1.80e-02 | 13 |
GO:20000092 | Colorectum | MSS | negative regulation of protein localization to cell surface | 7/3467 | 12/18723 | 2.45e-03 | 1.97e-02 | 7 |
GO:19037492 | Colorectum | MSS | positive regulation of establishment of protein localization to mitochondrion | 14/3467 | 36/18723 | 3.40e-03 | 2.56e-02 | 14 |
GO:00343941 | Colorectum | MSS | protein localization to cell surface | 22/3467 | 68/18723 | 4.37e-03 | 3.10e-02 | 22 |
GO:2000008 | Colorectum | MSS | regulation of protein localization to cell surface | 15/3467 | 41/18723 | 4.88e-03 | 3.40e-02 | 15 |
GO:00725943 | Colorectum | MSI-H | establishment of protein localization to organelle | 63/1319 | 422/18723 | 1.10e-08 | 1.33e-06 | 63 |
GO:19038293 | Colorectum | MSI-H | positive regulation of cellular protein localization | 41/1319 | 276/18723 | 4.49e-06 | 2.37e-04 | 41 |
GO:00066053 | Colorectum | MSI-H | protein targeting | 44/1319 | 314/18723 | 9.50e-06 | 4.55e-04 | 44 |
GO:00323863 | Colorectum | MSI-H | regulation of intracellular transport | 46/1319 | 337/18723 | 1.20e-05 | 5.48e-04 | 46 |
GO:19049513 | Colorectum | MSI-H | positive regulation of establishment of protein localization | 44/1319 | 319/18723 | 1.42e-05 | 6.31e-04 | 44 |
GO:00705853 | Colorectum | MSI-H | protein localization to mitochondrion | 22/1319 | 125/18723 | 5.73e-05 | 1.97e-03 | 22 |
GO:00331573 | Colorectum | MSI-H | regulation of intracellular protein transport | 33/1319 | 229/18723 | 6.86e-05 | 2.29e-03 | 33 |
GO:00726553 | Colorectum | MSI-H | establishment of protein localization to mitochondrion | 21/1319 | 120/18723 | 9.12e-05 | 2.93e-03 | 21 |
GO:00512223 | Colorectum | MSI-H | positive regulation of protein transport | 40/1319 | 303/18723 | 9.21e-05 | 2.94e-03 | 40 |
GO:00323883 | Colorectum | MSI-H | positive regulation of intracellular transport | 29/1319 | 202/18723 | 1.97e-04 | 5.30e-03 | 29 |
GO:00903163 | Colorectum | MSI-H | positive regulation of intracellular protein transport | 24/1319 | 160/18723 | 3.51e-04 | 8.20e-03 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LEPROT | deletion | Frame_Shift_Del | novel | c.165delC | p.Ile56SerfsTer47 | p.I56Sfs*47 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
LEPROT | deletion | Frame_Shift_Del | novel | c.87delT | p.Met31CysfsTer6 | p.M31Cfs*6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
LEPROT | SNV | Missense_Mutation | novel | c.373N>G | p.Phe125Val | p.F125V | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LEPROT | insertion | Frame_Shift_Ins | novel | c.70dupG | p.Ala24GlyfsTer44 | p.A24Gfs*44 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
LEPROT | SNV | Missense_Mutation | c.254N>A | p.Gly85Glu | p.G85E | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
LEPROT | SNV | Missense_Mutation | novel | c.346N>A | p.Ala116Thr | p.A116T | protein_coding | tolerated(0.56) | benign(0.031) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LEPROT | SNV | Missense_Mutation | novel | c.373N>C | p.Phe125Leu | p.F125L | protein_coding | deleterious(0.02) | probably_damaging(0.928) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
LEPROT | SNV | Missense_Mutation | novel | c.358N>A | p.Leu120Ile | p.L120I | protein_coding | tolerated(0.37) | benign(0.073) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
LEPROT | SNV | Missense_Mutation | novel | c.151N>T | p.His51Tyr | p.H51Y | protein_coding | tolerated(1) | benign(0) | TCGA-86-7954-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
LEPROT | SNV | Missense_Mutation | novel | c.121G>T | p.Val41Phe | p.V41F | protein_coding | deleterious(0.05) | possibly_damaging(0.881) | TCGA-97-7941-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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