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Gene: LAMTOR1 |
Gene summary for LAMTOR1 |
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Gene information | Species | Human | Gene symbol | LAMTOR1 | Gene ID | 55004 |
Gene name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |
Gene Alias | C11orf59 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q6IAA8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55004 | LAMTOR1 | GSM4909282 | Human | Breast | IDC | 2.28e-03 | 3.48e-01 | -0.0288 |
55004 | LAMTOR1 | GSM4909290 | Human | Breast | IDC | 3.14e-14 | 5.39e-01 | 0.2096 |
55004 | LAMTOR1 | GSM4909294 | Human | Breast | IDC | 8.16e-05 | 1.60e-01 | 0.2022 |
55004 | LAMTOR1 | GSM4909296 | Human | Breast | IDC | 1.44e-18 | 2.46e-01 | 0.1524 |
55004 | LAMTOR1 | GSM4909297 | Human | Breast | IDC | 2.24e-18 | -2.21e-01 | 0.1517 |
55004 | LAMTOR1 | GSM4909301 | Human | Breast | IDC | 1.02e-02 | 7.06e-02 | 0.1577 |
55004 | LAMTOR1 | GSM4909304 | Human | Breast | IDC | 1.24e-09 | 4.98e-01 | 0.1636 |
55004 | LAMTOR1 | GSM4909305 | Human | Breast | IDC | 1.16e-03 | 2.90e-01 | 0.0436 |
55004 | LAMTOR1 | GSM4909307 | Human | Breast | IDC | 4.22e-06 | 3.79e-01 | 0.1569 |
55004 | LAMTOR1 | GSM4909308 | Human | Breast | IDC | 3.82e-24 | 5.68e-01 | 0.158 |
55004 | LAMTOR1 | GSM4909311 | Human | Breast | IDC | 2.42e-35 | -2.77e-01 | 0.1534 |
55004 | LAMTOR1 | GSM4909312 | Human | Breast | IDC | 7.15e-19 | 1.16e-01 | 0.1552 |
55004 | LAMTOR1 | GSM4909313 | Human | Breast | IDC | 2.85e-05 | 2.46e-01 | 0.0391 |
55004 | LAMTOR1 | GSM4909316 | Human | Breast | IDC | 2.46e-07 | 2.54e-01 | 0.21 |
55004 | LAMTOR1 | GSM4909319 | Human | Breast | IDC | 7.76e-51 | -6.57e-02 | 0.1563 |
55004 | LAMTOR1 | GSM4909320 | Human | Breast | IDC | 9.82e-08 | 1.28e-01 | 0.1575 |
55004 | LAMTOR1 | GSM4909321 | Human | Breast | IDC | 3.59e-23 | 1.32e-01 | 0.1559 |
55004 | LAMTOR1 | brca2 | Human | Breast | Precancer | 3.20e-07 | 3.74e-01 | -0.024 |
55004 | LAMTOR1 | brca3 | Human | Breast | Precancer | 3.67e-02 | 2.72e-01 | -0.0263 |
55004 | LAMTOR1 | NCCBC11 | Human | Breast | DCIS | 2.53e-06 | 2.98e-01 | 0.1232 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00320082 | Esophagus | ESCC | positive regulation of TOR signaling | 31/8552 | 47/18723 | 4.01e-03 | 1.62e-02 | 31 |
GO:00302586 | Esophagus | ESCC | lipid modification | 116/8552 | 212/18723 | 4.90e-03 | 1.89e-02 | 116 |
GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:001605011 | Liver | Cirrhotic | vesicle organization | 133/4634 | 300/18723 | 7.35e-14 | 6.41e-12 | 133 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
GO:005508811 | Liver | Cirrhotic | lipid homeostasis | 74/4634 | 167/18723 | 2.46e-08 | 8.51e-07 | 74 |
GO:001619711 | Liver | Cirrhotic | endosomal transport | 93/4634 | 230/18723 | 1.01e-07 | 2.93e-06 | 93 |
GO:00070325 | Liver | Cirrhotic | endosome organization | 41/4634 | 82/18723 | 6.91e-07 | 1.47e-05 | 41 |
GO:004263211 | Liver | Cirrhotic | cholesterol homeostasis | 46/4634 | 96/18723 | 7.15e-07 | 1.52e-05 | 46 |
GO:005509211 | Liver | Cirrhotic | sterol homeostasis | 46/4634 | 97/18723 | 1.04e-06 | 2.13e-05 | 46 |
GO:001921611 | Liver | Cirrhotic | regulation of lipid metabolic process | 119/4634 | 331/18723 | 3.05e-06 | 5.39e-05 | 119 |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:00192181 | Liver | Cirrhotic | regulation of steroid metabolic process | 44/4634 | 100/18723 | 1.97e-05 | 2.62e-04 | 44 |
GO:0007040 | Liver | Cirrhotic | lysosome organization | 35/4634 | 74/18723 | 2.10e-05 | 2.77e-04 | 35 |
GO:0080171 | Liver | Cirrhotic | lytic vacuole organization | 35/4634 | 74/18723 | 2.10e-05 | 2.77e-04 | 35 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:00011013 | Liver | Cirrhotic | response to acid chemical | 52/4634 | 135/18723 | 2.65e-04 | 2.36e-03 | 52 |
GO:003025811 | Liver | Cirrhotic | lipid modification | 75/4634 | 212/18723 | 3.33e-04 | 2.87e-03 | 75 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa041504 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
hsa0415012 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMTOR1 | SNV | Missense_Mutation | c.24N>C | p.Glu8Asp | p.E8D | Q6IAA8 | protein_coding | tolerated(0.53) | benign(0) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
LAMTOR1 | SNV | Missense_Mutation | c.55N>T | p.Arg19Trp | p.R19W | Q6IAA8 | protein_coding | tolerated(0.2) | benign(0.047) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
LAMTOR1 | SNV | Missense_Mutation | rs761347517 | c.271N>T | p.Arg91Cys | p.R91C | Q6IAA8 | protein_coding | tolerated(0.09) | benign(0.018) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAMTOR1 | insertion | Frame_Shift_Ins | novel | c.86dupC | p.Thr30TyrfsTer20 | p.T30Yfs*20 | Q6IAA8 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LAMTOR1 | SNV | Missense_Mutation | c.272N>A | p.Arg91His | p.R91H | Q6IAA8 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LAMTOR1 | SNV | Missense_Mutation | novel | c.98N>C | p.Leu33Pro | p.L33P | Q6IAA8 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAMTOR1 | SNV | Missense_Mutation | rs370533903 | c.251N>A | p.Arg84His | p.R84H | Q6IAA8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAMTOR1 | SNV | Missense_Mutation | rs564426310 | c.136N>A | p.Ala46Thr | p.A46T | Q6IAA8 | protein_coding | tolerated(0.72) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAMTOR1 | SNV | Missense_Mutation | c.272N>A | p.Arg91His | p.R91H | Q6IAA8 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LAMTOR1 | SNV | Missense_Mutation | rs564426310 | c.136G>A | p.Ala46Thr | p.A46T | Q6IAA8 | protein_coding | tolerated(0.72) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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