Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/KDM4C_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/KDM4C_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/KDM4C_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/KDM4C_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KDM4C_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KDM4C_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KDM4C_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00082141 | Lung | IAC | protein dealkylation | 11/2061 | 33/18723 | 5.41e-04 | 7.57e-03 | 11 |
GO:00709881 | Lung | IAC | demethylation | 18/2061 | 73/18723 | 7.56e-04 | 9.82e-03 | 18 |
GO:00097557 | Lung | IAC | hormone-mediated signaling pathway | 36/2061 | 190/18723 | 7.95e-04 | 1.02e-02 | 36 |
GO:00305216 | Lung | IAC | androgen receptor signaling pathway | 11/2061 | 44/18723 | 6.90e-03 | 4.75e-02 | 11 |
GO:001657012 | Lung | AIS | histone modification | 81/1849 | 463/18723 | 2.30e-07 | 2.16e-05 | 81 |
GO:003052213 | Lung | AIS | intracellular receptor signaling pathway | 53/1849 | 265/18723 | 4.57e-07 | 3.55e-05 | 53 |
GO:003051812 | Lung | AIS | intracellular steroid hormone receptor signaling pathway | 28/1849 | 116/18723 | 6.14e-06 | 2.82e-04 | 28 |
GO:007138313 | Lung | AIS | cellular response to steroid hormone stimulus | 41/1849 | 204/18723 | 7.76e-06 | 3.35e-04 | 41 |
GO:004854513 | Lung | AIS | response to steroid hormone | 59/1849 | 339/18723 | 1.15e-05 | 4.65e-04 | 59 |
GO:004340112 | Lung | AIS | steroid hormone mediated signaling pathway | 28/1849 | 136/18723 | 1.32e-04 | 2.97e-03 | 28 |
GO:003314312 | Lung | AIS | regulation of intracellular steroid hormone receptor signaling pathway | 18/1849 | 74/18723 | 2.42e-04 | 4.78e-03 | 18 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:000975512 | Lung | AIS | hormone-mediated signaling pathway | 33/1849 | 190/18723 | 9.44e-04 | 1.25e-02 | 33 |
GO:003052112 | Lung | AIS | androgen receptor signaling pathway | 11/1849 | 44/18723 | 3.01e-03 | 2.97e-02 | 11 |
GO:001657022 | Lung | MIAC | histone modification | 45/967 | 463/18723 | 3.58e-05 | 1.97e-03 | 45 |
GO:007138323 | Lung | MIAC | cellular response to steroid hormone stimulus | 25/967 | 204/18723 | 5.46e-05 | 2.75e-03 | 25 |
GO:004854523 | Lung | MIAC | response to steroid hormone | 34/967 | 339/18723 | 1.73e-04 | 6.42e-03 | 34 |
GO:003052223 | Lung | MIAC | intracellular receptor signaling pathway | 27/967 | 265/18723 | 6.08e-04 | 1.50e-02 | 27 |
GO:003314322 | Lung | MIAC | regulation of intracellular steroid hormone receptor signaling pathway | 11/967 | 74/18723 | 1.39e-03 | 2.51e-02 | 11 |
GO:003051822 | Lung | MIAC | intracellular steroid hormone receptor signaling pathway | 14/967 | 116/18723 | 2.62e-03 | 3.71e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM4C | SNV | Missense_Mutation | rs780836880 | c.362N>A | p.Arg121His | p.R121H | Q9H3R0 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
KDM4C | SNV | Missense_Mutation | rs182255463 | c.676N>G | p.Gln226Glu | p.Q226E | Q9H3R0 | protein_coding | tolerated(0.24) | benign(0.24) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KDM4C | SNV | Missense_Mutation | rs191848178 | c.1888N>T | p.Ala630Ser | p.A630S | Q9H3R0 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM4C | SNV | Missense_Mutation | novel | c.1611N>A | p.Asn537Lys | p.N537K | Q9H3R0 | protein_coding | tolerated(0.2) | benign(0.014) | TCGA-BH-A6R8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KDM4C | SNV | Missense_Mutation | | c.1439N>A | p.Ile480Lys | p.I480K | Q9H3R0 | protein_coding | tolerated(0.95) | benign(0) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM4C | SNV | Missense_Mutation | | c.145N>C | p.Val49Leu | p.V49L | Q9H3R0 | protein_coding | deleterious(0) | benign(0.013) | TCGA-D8-A1X6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
KDM4C | SNV | Missense_Mutation | rs373633491 | c.1192N>A | p.Ala398Thr | p.A398T | Q9H3R0 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
KDM4C | SNV | Missense_Mutation | | c.1352C>T | p.Ser451Leu | p.S451L | Q9H3R0 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KDM4C | insertion | Frame_Shift_Ins | novel | c.1907_1908insCTGGTGCTCTGTAAGATTTTATAAAGTGCTGTTCTTGTGGAGT | p.Thr637TrpfsTer37 | p.T637Wfs*37 | Q9H3R0 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KDM4C | deletion | Frame_Shift_Del | | c.2601delN | p.Asn869ThrfsTer2 | p.N869Tfs*2 | Q9H3R0 | protein_coding | | | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | PYROGALLOL RED | PYROGALLOL RED | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Pyrido[1,2-a]indole-1.-carboxylic acid analog 2 | | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Pyrido[1,2-a]indole-1.-carboxylic acid analog 4 | | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | PYRIDINE-2,4-DICARBOXYLIC ACID | CHEMBL316034 | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | SKF-38393 | SKF-38393 | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Pyrido[1,2-a]indole-1.-carboxylic acid analog 7 | | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | TYRPHOSTIN 23 | TYRPHOSTIN 23 | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | PMID25468267-Compound-46 | | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | N-METHOXYCARBONYLMETHYL-OXALAMIC ACID METHYL ESTER | CHEMBL92309 | 19359167 |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Pyrido[1,2-a]indole-1.-carboxylic acid analog 1 | | |